教育背景
2006年获安徽医科大学药理学硕士学位,2009年获中国药科大学药理学博士学位。
工作经历
2009年赴美国Virginia Commonwealth University从事博士后研究,2014年9月作为海外高层次引进人才进入中国药科大学工作
项目课题经历
目前作为负责人主持以下国家和省部级科研项目:十三五“重大新药创制”科技重大专项(2017ZX09301066),国家自然科学基金面上项目(81773732),国家自然科学基金面上项目(81570413),江苏省自然科学基金面上项目(BK20161461),中国药科大学高层次引进人才启动基金和中央高校基本科研业务费项目等
论文、成果、著作等
Li Q, Su J, Jin SJ, Wei W, Cong XD, Li XX, Xu M. Argirein alleviates vascular endothelial insulin resistance through suppressing the activation of Nox4-dependent O2- production in diabetic rats. Free Radic Biol Med. 2018 Jun; 121:169-179.
(2)Li X, Jin SJ, Su J, Li XX, Xu M. Acid sphingomyelinase downregulation alleviates vascular endothelial insulin resistance in diabetic rats. Basic Clin Pharmacol Toxicol. 2018 Jun 19. doi: 10.1111/bcpt.13073.
(3)An XR, Li X, Wei W, Li XX, Xu M.Prostaglandin E1 Inhibited Diabetes-Induced Phenotypic Switching of Vascular Smooth Muscle Cells Through Activating Autophagy.Cell Physiol Biochem. 2018 Oct 11; 50(2):745-756.
(4)Wei W, An XR, Jin SJ, Li XX, Xu M. Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy. Sci Rep. 2018; 8(1):9.
(5)Li Q, Li J, Shao H, Li XX, Yu F, Xu M. Inhibition of CPU0213, a Dual Endothelin Receptor Antagonist, on Apoptosis via Nox4-Dependent ROS in HK-2 Cells. Cell Physiol Biochem. 2016; 39(1):183-92.
(6)Li J, Zhang L, Jiang Z, He X, Zhang L, Xu M. Expression of Renal Aquaporins in Aristolochic Acid I and Aristolactam I-Induced Nephrotoxicity. Nephron. 2016; 133(3):213-21.
(7)Xu M, Hu C, Khan HH, Shi FH, Cong XD, Li Q, Dai Y, Dai DZ. Argirein alleviates stress-induced and diabetic hypogonadism in rats via normalizing testis endothelin receptor A and connexin 43.Acta Pharmacol Sin. 2016; 37(2):246-54.
(8)Xu M, Zhang Q, Li PL, Nguyen T, Li X, Zhang Y. Regulation of dynein-mediated autophagosomes trafficking by ASM in CASMCs.Front Biosci (Landmark Ed). 2016; 21:696-706.
(7)Xu M, Li XX, Wang L, Wang M, Zhang Y, Li PL. Contribution of Nrf2 to Atherogenic Phenotype Switching of Coronary Arterial Smooth Muscle Cells Lacking CD38 Gene. Cell Physiol Biochem. 2015; 37:432-44.
(9)Xu M, Li XX, Chen Y, Pitzer AL, Zhang Y, Li PL. Enhancement of dynein-mediated autophagosome trafficking and autophagy maturation by ROS in mouse coronary arterial myocytes. J Cell Mol Med. 2014; 18(11):2165-75.
(10)Zhang Y, Xu M (Co-first author), Xia M, Li X, Boini KM, Wang M, Gulbins E, Ratz PH, Li PL. Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene. Cardiovasc Res. 2014; 102(1):68-78.
(11)Xu M, Li XX, Xiong J, Xia M, Gulbins E, Zhang Y, Li PL. Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes. Biochim Biophys Acta. 2013; 1833(12):3228-36.
(12)Xu M, Li XX, Ritter JK, Abais JM, Zhang Y, Li PL. Contribution of NADPH oxidase to membrane CD38 internalization and activation in coronary arterial myocytes. PLoS One. 2013; 8(8):e71212.
(13)Xu M, Li X, Walsh SW, Zhang Y, Abais JM, Boini KM, Li PL. Intracellular two-phase Ca2+ release and apoptosis controlled by TRP-ML1 channel activity in coronary arterial myocytes. Am J Physiol Cell Physiol. 2013; 304(5):C458-66.
(14)Xu M, Xia M, Li XX, Han WQ, Boini KM, Zhang F, Zhang Y, Ritter JK, Li PL. Requirement of translocated lysosomal V1 H(+)-ATPase for activation of membrane acid sphingomyelinase and raft clustering in coronary endothelial cells. Mol Biol Cell. 2012; 23(8):1546-57.
(15)Xu M, Zhang Y, Xia M, Li XX, Ritter JK, Zhang F, Li PL.NAD(P)H oxidase-dependent intracellular and extracellular O2•- production in coronary arterial myocytes from CD38 knockout mice. Free Radic Biol Med. 2012; 52(2):357-65.
(16)Xu M, Tang YQ, Dai DZ, Zheng YF, Cheng YS, Zhang Q, Dai Y. Comparison of sildenafil with strontium fructose diphosphate in improving erectile dysfunction against upregulated cavernosal NADPH oxidase, protein kinase Cå, and endothelin system in diabetic rats. J Pharm Pharmacol. 2012; 64(2):244-51.
(17)Xu M, Dai DZ, Zhang Q, Cheng YS, Dai Y. Upregulated NADPH oxidase contributes to diabetic testicular complication and is relieved by strontium fructose 1,6-diphosphate. Exp Clin Endocrinol Diabetes. 2010; 118(7):459-65.
(18)Xu M, Ji H, Dai DZ, Tang XY, Dai Y. Protective effect of the endothelin antagonist CPU0213 against isoprenaline-induced heart failure by suppressing abnormal expression of leptin, calcineurin and SERCA2a in rats. J Pharm Pharmacol. 2008; 60(6):739-45.
(19)Xu M, Dai DZ, Dai Y. Normalizing NADPH Oxidase Contributes to Attenuating Diabetic Nephropathy by a Dual Endothelin Receptor Antagonist CPU0213 in Rats. Am J Nephrol. 2008; 29(3):252-6.
专利、著作版权等
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