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辛贵忠

领域:生物产业 学校:中国药科大学职称:副教授

①现代质谱技术结合多元统计分析的中药质量控制研究。主持项目:国家自然科学基金青年科学基金项目,基于木质牙签离子化技术的代谢组学平台的建立及其在川贝母基原鉴定和亲缘学研究中的应用(批准号:81403057;起讫时间:2015-2017),项目负责人。 ②基于功能代谢组学及宏基因组学阐明中药干预复杂性疾病的作用机理,如免疫性疾病及代谢性疾病等。资助项目:国家自然科学基金面上项目,基于“肺-肠”微生态-代谢-免疫轴的川贝母活性物质组治疗哮喘的作用机制研究(批准号:81773872;起讫时间:2018-2021Цᯬ...

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教育背景

2012年毕业于中国药科大学生药学专业,获得博士学位。

工作经历

2012年10月至2014年7月,在香港科技大学进行博士后研究

项目课题经历

主持国家自然科学基金2项

论文、成果、著作等

Wang C, Yin YH, Wei YJ, Shi ZQ, Liu JQ, Liu LF, Xin GZ,Rapid identification of herbal compounds derived metabolites using zebrafish larvae as the biotransformation system. J Chromatogr A. 2017, 1515: 100-108.

[2]Wang L, Liu LF, Wang JY, Shi ZQ, Chang WQ, Chen ML, Yin YH, Jiang Y, Li HJ, Li P, Yao ZP, Xin GZ. A strategy to identify and quantify closely related adulterant herbal materials by mass spectrometry-based partial least squares regression. Anal Chim Acta. 2017, 977: 28-35.

[3]Chang WQ, Zhou JL, Li Y, Shi ZQ, Wang L, Yang J, Li P, Liu LF, Xin GZ. An in vitro approach for lipolysis measurement using high-resolution mass spectrometry and partial least squares based analysis. Anal Chim Acta. 2017, 950: 138-146.

[4]Chen ML, Chang WQ, Zhou JL, Yin YH, Xia WR, Liu JQ, Liu LF, Xin GZ, Comparison of three officinal species of Callicarpa based on a biochemome profiling strategy with UHPLC-IT-MS and chemometrics analysis. J Pharm Biomed Anal. 2017, 145: 666-674.

[5]Li R, Guo LX, Li Y, Chang WQ, Liu JQ, Liu LF, Xin GZ. Dose-response characteristics of Clematis triterpenoid saponins and clematichinenoside AR in rheumatoid arthritis rats by liquid chromatography/mass spectrometry-based serum and urine metabolomics. J Pharm Biomed Anal. 2017, 136: 81-91.

[6]Li Y, Zheng JY, Liu JQ, Yang J, Liu Y, Wang C, Ma XN, Liu BL, Xin GZ, Liu LF. Succinate/NLRP3 Inflammasome Induces Synovial Fibroblast Activation: Therapeutical Effects of Clematichinenoside AR on Arthritis. Front Immunol. 2016, 7: 532.

[7]Wang L, Yao ZP, Li P, Chen SB, So PK, Shi ZQ, Hu B, Liu LF, Xin GZ. Global detection and semi-quantification of Fritillaria alkaloids in Fritillariae Ussuriensis Bulbus by a non-targeted multiple reaction monitoring approach. J Sep Sci. 2016, 39(2): 287-95.

[8]Xin GZ, Hu B, Shi ZQ, Zheng JY, Wang L, Chang WQ, Li P, Yao Z, Liu LF. A direct ionization mass spectrometry-based approach for differentiation of medicinal Ephedra species. J Pharm Biomed Anal. 2016, 117: 492-8.

[9]Guo LX, Li R, Liu K, Yang J, Li HJ, Li SL, Liu JQ, Liu LF, Xin GZ. Structural characterization and discrimination of Chinese medicinal materials with multiple botanical origins based on metabolite profiling and chemometrics analysis: Clematidis Radix et Rhizoma as a case study. J Chromatogr A. 2015, 1425: 129-40.

[10]Xin GZ, Hu B, Shi ZQ, Lam YC, Dong TT, Li P, Yao ZP, Tsim KW. Rapid identification of plant materials by wooden-tip electrospray ionization mass spectrometry and a strategy to differentiate the bulbs of Fritillaria. Anal Chim Acta. 2014, 820: 84-91.

专利、著作版权等

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