教育背景
。1989年毕业于中国药科大学中药学专业
工作经历
2013年8月至2014年8月于美国北卡罗莱纳大学任访问学者
项目课题经历
目前主持2项国家自然科学基金课题(从"激活PPARγ-调节Th17/Treg平衡"的角度阐明积雪草主要有效成分抑制溃疡性结肠炎的机制,2014年-2017年;基于肠道黏膜免疫系统揭示羟基积雪草苷抗类风湿关节炎的作用机制和活性形式,2012年-2015年)、2项省部级课题的研究工作,参与国家重大新药创制、江苏省高技术研究计划、国家新药基金等多项纵向课题,负责新药研发项目7项。
论文、成果、著作等
In vivo disposition and metabolism of madecassoside, a major bioactive constituent in Centella asiatica (L.) Urb. Journal of Ethnopharmacology, 2013, 150: 601-608.
2. Intestinal interleukin-10 mobilization as a contributor to the anti-arthritis effect of orally administered madecassoside: A unique action mode of saponin compounds with poor bioavailability. Biochemical Pharmacology, 2015, 94: 30–38.
3. Gleditsioside B, a triterpene saponin isolated from the anomalous fruits of Gleditsia sinensis Lam., abrogates bFGF-induced endothelial cell migration through preventing the activation of MMP-2 and FAK via inhibiting ERK and PI3K/AKT signaling pathways. Vascular Pharmacology, 2013, 58(1-2):118-126.
4. Norisoboldine Suppresses VEGF-Induced Endothelial Cell Migration via the cAMP-PKA-NF-kB/Notch1 Pathway. PLOS ONE, 2013, 8(12):e81220.
5. Norisoboldine induces apoptosis of fibroblast-like synoviocytes from adjuvant- induced arthritis rats. International Immunopharmacology, 2014, 20(1):110-116.
6. Norisoboldine ameliorates collagen-induced arthritis through regulating the balance between Th17 and regulatory T cells in gut-associated lymphoid tissues. Toxicology and Applied Pharmacology 2015, 282(1): 90–99
专利、著作版权等
申报发明专利3项,获授权2项
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