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吴洁

领域:生物产业 学校:中国药科大学职称:教授

主要从事糖尿病等自身免疫性疾病的发病机制及相关药物研究...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

2004年获微生物与生化药学博士学位

工作经历

项目课题经历

国家自然科学基金,课题名称:葡萄球菌核酸酶介导NETs降解在T1DM防治中的作用机制研究,项目批准号:81673340,在研

江苏省基础研究计划(自然科学基金),课题名称:乳酸菌递呈的葡萄球菌核酸酶在T1DM防治中的作用与机制研究,项目批准号:BK20161462,在研

国家自然科学基金,课题名称:乳酸菌在粘膜给药疫苗递呈载体中的应用,项目批准号:81172973,完成

国家自然科学基金青年基金,课题名称: 疫苗多肽纳米载药新分子的研究,项目批准号:30500458,完成

论文、成果、著作等

Lang J, Wang X, Liu K, He D, Niu P, Cao R, Jin L, Wu J*. Oral delivery of staphylococcal nuclease by Lactococcus lactisprevents type 1 diabetes mellitus in NOD mice. Appl Microbiol Biotechnol. 2017 Sep, 101:7653–62

2.Lili Shen, shiping Lu,Dongcheng Huang , Guoliang Li, Kunfeng Liu, Li Zong,Liang Jin*, Jie Wu*,Vaccination against type 1 diabetes with a novel peptide IA-2-P2 in streptozotocin-induced diabetic mice,Diabetes and Vascular Disease Research,2017 May;14(3):184-190.

3.Ma Y,Liu J,Hou J,Dong Y,Lu Y,Jin L,Cao R,Li T,Wu J*, Oral administration of recombinant Lactococcus lactis expressing HSP65 and tandemly repeated P277 reduces the incidence of type I diabetes in non-obese diabetic mice,PLoS One,2014 Aug 26;9(8) :1298-1302

4.Zhang J*, Wu J*, Gu C, Noble NA, Border WA, Huang Y. Receptor-mediated non-proteolytic activation of prorenin and induction of TGFss1 and PAI-1 expression in renal mesangial cells. Am J Physiol Renal Physiol. 2012 Jul;303(1): 11-20

5.Jun L, Jie L, Dongping Y,Xin Y, Taiming Li, Rongyue C, Wu J*, Jingjing L, Effect of nasal immunization of multi-target preventive vaccines on atherosclerosis, Vaccine,2012,30:1023-31

6.Yong L, Huiyong Z, Jing H, Huaqian W, Xiangbing H, Yanjun M, Xiaoyu G, Li H, Yanan Y, Rongyue C, Hao F, Jingjing L, Jie W*.Vaccination with a potent DNA vaccine targeting B-cell epitopes of hGRP induces prophylactic and therapeutic antitumor activity in vivo.Gene Ther. 2010 Apr;17(4):459-68.

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