2001年毕业于汉中师范学院，获化学教育专业学士学位；2005年毕业于陕西师范大学，获有机化学专业硕士学位；2008年毕业于中国药科大学，获药物化学专业博士学位

2008年7月留校天然药物化学教研室任教，承担本科生《天然药物化学》、《波谱解析》和研究生《高等波谱解析》等课程教学工作。

1.国家自然科学基金面上项目，基于天然产物“优势结构”和药物“活性片段”具有均衡活性的多靶点阿尔茨海默病药物分子研究，编号：81573313, 2016 ~ 2019.

2.江苏省自然科学基金青年项目，若干常见中草药活性成分的酶促生物转化研究，编号：BK20130664, 2013 ~ 2016

Palladium-Catalyzed meta-C-H Olefination of Arene-Tethered Diols Directed by Well-Designed Pyrimidine-Based Group. Organic letters, 2019,21 (6), 1841-1844.

2.Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease. European Journal of Medicinal Chemistry,2019,163, 307-319.

3.Qing-Feng Wu, Xiao-Bing Wang, Peng-Xiang Shen, Jin-Quan Yu, Enantioselective C–H Arylation and Vinylation of Cyclobutyl Carboxylic Amides, ACS Catalysis, 2018, 2577-2581. DOI: 10.1021/acscatal.8b00069 (Q.-F.W. and X.-B.W. contributed equally to this work.)

4.Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties. European Journal of Medicinal Chemistry, 2018, 157, 161-176.

5.Novel 8-hydroxyquinoline derivatives targeting beta-amyloid aggregation, metal chelation and oxidative stress against Alzheimer's disease. Bioorganic & Medicinal Chemistry, 2018, 26, 3191-3201.

6.Qing-Feng Wu, Peng-Xiang Shen, Jian He, Xiao-Bing Wang, Forrest Zhang, Qian Shao, Ru-Yi Zhu, Claudio Mapelli, Jennifer X. Qiao, Michael A. Poss, Jin-Quan Yu*, Formation of α-chiral centers by asymmetric β-C(sp3)–H arylation, alkenylation, and alkynylation. Science, 2017, 355, 499-503. DOI: 10.1126/science.aal5175

7.Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. European Journal of Medicinal Chemistry, 2017, 139, 68-83.

8.Rational Design and Multibiological Profiling of Novel Donepezil–Trolox Hybrids against Alzheimer’s Disease, with Cholinergic, Antioxidant, Neuroprotective, and Cognition Enhancing Properties. ACS Chemical Neuroscience, 2017, 8, 2496-2511.

9.Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid-β aggregation for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 2017, 138, 715-728.

10.Synthesis and pharmacological evaluation of multi-functional homoisoflavonoid derivatives as potent inhibitors of monoamine oxidase B and cholinesterase for the treatment of Alzheimer's disease. MedChemComm. 2017, 8, 1459-1467.

11.Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease. Bioorganic & Medicinal Chemistry,2017, 25, 3815-3826.

12.Polycyclic xanthones viapH-switched biotransformation of α-mangostin catalysed by horseradish peroxidase exhibited cytotoxicity against hepatoblastoma cells in vitro. Journal of Functional Foods2017, 28, 205-214.

13.Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease. Bioorg Med Chem, 2017, 25, 5917-5928.

14.Experimental and theoretical calculation studies on the structure elucidation and absolute configuration of calyxins from Alpinia katsumadai. Fitoterapia, 2017, 119, 121-129.

15.Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 2016, 123, 282-297.

16.Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin. Bioorganic & Medicinal Chemistry, 2016, 24, 4324-38.

17.Synthesis and evaluation of donepezil–ferulic acid hybrids as multi-target-directed ligands against Alzheimer's disease. MedChemComm. 2016, 7, 990-998.

18.Design, synthesis and biological evaluation of novel donepezil–coumarin hybrids as multi-target agents for the treatment of Alzheimer’s disease. Bioorganic & Medicinal Chemistry 2016,24, 1528-1539.

19.Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer's disease. Journal of Enzyme Inhibition and Medicinal Chemistry,2016, 41-53, DOI: 10.1080/14756366.2016.1201814.

20.Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease. European Journal of Medicinal Chemistry, 2015, 95, 153-165.

21.Design of a structural framework with potential use to develop balanced multifunctional agents against Alzheimer's disease. RSC Advances, 2015, 5, 14242-14255.

22.Chromanones: selective and reversible monoamine oxidase B inhibitors with nanomolar potency. Medchemcomm, 2015, 6, 1293-1302.

23.Design and application of a biphasic system that enhances productivity of Daucus carota-catalyzed asymmetric reduction. Biotechnology Letters, 2015, 37, 1703-1709.

24.Multifunctional coumarin derivatives: Monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters, 2015, 25, 508-513.

25.Multifunctional tacrine–trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties. European Journal of Medicinal Chemistry, 2015, 93, 42-50.

26.Multifunctional 3-Schiff base-4-hydroxycoumarin derivatives with monoamine oxidase inhibition, anti-β-amyloid aggregation, metal chelation, antioxidant and neuroprotection properties against Alzheimer's disease. RSC Advances, 2015, 5, 70395-70409.

获6项发明专利