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汪豪

领域:生物产业 学校:中国药科大学职称:教授

①中药药效物质基础、及创新药物研究; ②天然药物活性成分结构、及生物学功能研究。...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

1993年7月毕业于安徽中医学院药学专业,获学士学位。1999年9月考入中国药科大学攻读天然药物化学专业硕士研究生,2001年9月提前攻博, 2004年6月获得天然药物化学专业博士学位

工作经历

项目课题经历

①十三五重大新药创制项目:天然药物来源1类新药Sm-5临床前研究(2017ZX09309024,

2017. 1~2020. 12,主持);

②国家自然科学基金面上项目: 雷公藤属木栓烷类化合物Lck激酶抑制构效关系与作用机

制研究 (81573309, 2016. 1~2019. 12, 主持);

③国家自然科学基金面上项目: 鸡骨草黄酮碳苷类化合物的ALK5激酶抑制构效关系与作

用机制研究 (81172955, 2012.1~2015.12, 主持);

④十二五重大新药创制滚动项目: 中药五类新药鸡骨草总黄酮碳苷的临床前研究 (2013ZX 09301303-003, 2013.1~ 2015.12, 主持);

⑤十一五重大新药创制项目:中药五类新药鸡骨草总黄酮碳苷的创新药物研究(2009ZX

09103-315, 2009. 1~2010. 12, 编号:主持);

⑥十一五重大新药创制项目: 治疗糖尿病肾病一类新药大黄酸的临床研究(2008ZX09101

–050, 2009.01~2010.12, 参加, 负责工艺及质量研究),2012年获得新药II期临床批件。

论文、成果、著作等

1.Hou J. Q., Wang H.*, et al. Frutescone A-G, tasmanone-based Meroterpenoids from the aerial parts of Baeckea frutescens, J. Org. Chem., 2017, 82, 1448-1457.

2.Hu X. L., Wang H.*, et al. Synthesis and biological evaluation of clovamide analogues

as potent anti-neuroinflammatory agents in vitro and in vivo, Eur. J Med. Chem. 2018,

151, 261~271.

3.Pham T. A. #, Hu X. L.#, Wang H.*, et al. Phloroglucinols with immunosuppressive activities from the fruits of Eucalyptus globulus, J. Nat. Prod. 2019, 82, 859−869.

4. Hou J. Q., Yan M.*, Wang H.*, et al. Anti-inflammatory meroterpenoids from Baeckea

frutescens , J. Nat. Prod., 2017, 80, 2204−2214.

5.Hu X. L., Wang H.*, et al. Stereoisomers of schisandrin B are potent ATP competitive

GSK-3β inhibitors with neuroprotective effects against Alzheimer’s Disease: Stereochemistry and biological activity, ACS Chem. Neurosci., 2018, 10: 996~1007.

6.Hu X. L., Wang H.*, et al. Identification of amentoflavone as a potent highly selective PARP-1 inhibitor and its potentiation on carboplatin in human non-small cell lung cancer, Phytomedicine, 2018, 50, 88-98.

7.Liu W., Yang J.*, Wang H.*, et al. Aspafilioside B induces G2/M cell cycle arrest and apoptosis by up-regulating H-Ras and N-Ras via ERK and p38 MARK signaling pathways in human hepatoma hepG2 cells, Molecular carcinogenesis, 2016, 55, 440-457.

8.Hou J. Q., Wang H.*, et al. Isolation and characterization of related impurities in andrographolide sodium bisulphite injection. RSC Advances, 2016, 6, 28830-28837.

9.Xiong F., Wang H.*, et al. Integrated pharmacokinetics and biodistribution of multiple flavonoid C-glycosides components in rat after oral administration of Abrus mollis extract and correlations with bio-effects. Journal of Ethnopharmacology, 2015, 163 (3): 290-29.

10.Wang H.*, Ye W. C.*, et al. Isolation and structure characterization of related impurities in etimicin sulfate by LC/ESI-MSn and NMR. J. Pharm. Biomed. Anal., 2011, 55, 902-907.

专利、著作版权等

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