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谭宁华

领域:生物产业 学校:中国药科大学职称:教授

中药化学、中药药理学、抗肿瘤新药研究...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

1984年学士毕业于贵阳医学院药学系,1990年硕士毕业于中国药科大学天然药物化学专业,1993年博士毕业于中国药科大学天然药物化学专业。

工作经历

1984-1987年贵阳医学院药学系教师,1993-1995年中国科学院昆明植物研究所植物化学博士后,1996-2015年中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室研究组长、副研究员、研究员和副主任,2015年至今中国药科大学教授。1996、1998、2006、2008年先后到德国BAYER药物研究所、美国NCI、澳大利亚昆士兰大学和美国威斯康星大学从事合作研究。

项目课题经历

论文、成果、著作等

1.Clara Bik-San Lau*, Grace Gar-Lee Yue, Kwok-Pui Fung, Ning-Hua Tan, Ping-Chung Leung. The potential roles of Chinese herbal medicines in cancer management. Science, 2015, 347 (6219 suppl): S45-S47
2.Hoi-Wing Leung, Zhe Wang, Grace Gar-Lee Yue, Si-Meng Zhao, Julia Kin-Ming Lee, Kwok-Pui Fung, Ping-Chung Leung, Clara Bik-San Lau*, Ning-Hua Tan*. Cyclopeptide RA-V inhibits cell adhesion and invasion in both estrogen receptor positive and negative breast cancer cells probably via PI3K/AKT and NF-kBsignaling pathways. BBA Molecular Cell Research, 2015, 1853: 1827-1840
3.Zeng-Ying Qiao, Di Zhang, Chun-Yuan Hou, Si-Meng Zhao, Ya Liu, Yu-Juan Gao, Ning-Hua Tan*, Hao Wang*. A PH-responsive natural cyclopeptide RA-V drug formulation for improved breast cancer therapy. Journal of Materials Chemistry B, 2015, 3: 4514-4523
4.Hoi-Wing Leung, Si-Meng Zhao, Grace Gar-Lee Yue, Julia Kin-Ming Lee, Kwok-Pui Fung, Ping-Chung Leung, Ning-Hua Tan*, Clara Bik-San Lau*. RA-XII inhibits tumour growth and metastasis in breast tumour bearing mice via reducing cancer cell adhesion and invasion and promoting matrix degradation. Scientific Reports, 2015, 5:16985
5.Zhe Wang, Si-Meng Zhao, Li-Mei Zhao, Xiao-Qiang Chen, Guang-Zhi Zeng*, Ning-Hua Tan*. Rubipodanin A, the first natural N-desmonomethyl Rubiaceae-type cyclopeptide from Rubia podantha, indicating an important role of the N9-methyl group in the conformation and bioactivity. PLoS ONE, 2015, 5: e144950
6.Na-Na Liu, Si-Meng Zhao, Jing-Feng Zhao, Guang-Zhi Zeng, Ning-Hua Tan*, Jian-Ping Liu*. Synthesis and conformation studies of rubiyunnanin B analogs. Tetrahedron, 2014, 70(37): 6630-6640
7.Mao-Bo Huang, Si-Meng Zhao, Guang-ZhiZeng*, Bin Kuang, Xiao-Qiang Chen, Ning-Hua Tan*. Rubischumanins A-C, three cytotoxic cyclopeptides from Rubiaschumanniana. Tetrahedron, 2014, 70: 7627-7631
8.Si-Meng Zhao, Zhe Wang, Guang-ZhiZeng*, Wei-Wu Song, Xiao-Qiang Chen, Ning-Hua Tan*. Novel cytotoxic naphthohydroquinone dimers from Rubiaalata. Organic Letters, 2014, 16: 5576-5579
9.Wen-Yan Xu, Bo Wang, Yuan Lin*, Yu-Hua Li, Zhao-Hui Su, Wen-Jun He, Ning-Hua Tan*, Qian Wang. Emulsion stabilized by mini cyclic proteins for bioactive compounds delivery. RSC Advances, 2014, 4: 48000-48003
10.Lai Yue Chan, Wen-Jun He, Ning-Hua Tan*, Guang-Zhi Zeng, David J. Craik, Norelle L. Daly*. A new family of cystine knot peptides from the seeds of Momordica cochinchinensis. Peptides, 2013, 39: 29-35
11.Grace G.L. Yue, Ben C.L. Chan, Hin-Fai Kwok, Yuk-Lau Wong, Hoi-Wing Leung, Chang-JiuJi, Kwok-Pui Fung, Ping-Chung Leung, Ning-Hua Tan*, Clara B.S. Lau*. Anti-angiogenesis and immunomodulatory activities of an anti-tumor sesquiterpene bigelovin isolated from Inula helianthus-aquatica. European Journal of Medicinal Chemistry, 2013, 59: 243-252
12.Xian-Ying Fang, Wei Chen, Jun-Ting Fan, Ran Song, Lu Wang, Yan-Hong Gu, Guang-Zhi Zeng, Yan Shen, Xue-Feng Wu, Ning-Hua Tan*, Yang Sun*, Qiang Xu*. Plant cyclopeptide RA-V kills human breast cancer cells by inducing mitochondria-mediated apoptosis through blocking PDK1-AKT interaction. Toxicology and Applied Pharmacology, 2013, 267: 95-103
13.Hui-Min Xu, Hua Yi, Wen-Bing Zhou, Wen-Jun He, Guang-Zhi Zeng, Wen-Yan Xu, Ning-Hua Tan*. Tataricins A-B, two novel cyclotetrapeptides from Aster tataricus, and their absolute configuration assignment. Tetrahedron Letters, 2013, 54: 1380-1383
14.Hui-Min Xu, Guang-Zhi Zeng, Wen-Bing Zhou, Wen-Jun He, Ning-Hua Tan*. Astins K-P, six new chlorinated cyclopentapeptides from Aster tataricus. Tetrahedron, 2013, 69: 7964-7969
15.Wen-Jun He, Lai Yue Chan, Richard J. Clark, Jun Tang, Guang-Zhi Zeng, Octavio L. Franco, Cinzia Cantacessi, David J. Craik, Norelle L. Daly*, Ning-Hua Tan*. Novel inhibitor cyctine knot peptides from Momordica charantia. PLOS ONE, 2013, 8(10): e75334
16.Wen-Jun He, Zhao-Hui Fu, Guang-Zhi Zeng, Yu-Mei Zhang*, Hong-Jing Han, He Yan, Chang-Jiu Ji, Hong-Biao Chu, Ning-Hua Tan*. Terpene and lignan glycosides from the twigs and leaves of an endangered conifer, Cathaya argyrophylla. Phytochemistry, 2012, 83:63-69
17.Wen-Yan Xu, Hong-Tao Zhu, Ning-Hua Tan*, Jun Tang, Ying-Jun Zhang, Ron L. Cerny, Liangcheng Du*. Biosynthetic studies of plant cyclopeptide heterophyllin B from the Chinese medicinal plant Pseudostellaria heterophylla. Plant Cell, Tissue & Organ Culture, 2012, 108: 137-14
18.Jun-JuXu, Chang-Jiu Ji, Yu-Mei Zhang, Jia Su, Yan Li, Ning-Hua Tan*. Inhibition of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide. Bioorganic & Medicinal Chemistry Letters, 2012, 22: 1660-1663
19.Chang-Jiu Ji, Guang-Zhi Zeng, Jing Han, Wen-Jun He, Yu-Mei Zhang,Ning-Hua Tan*. Zizimauritic acids A-C, three novel nortriterpenes isolated from Ziziphus mauritiana. Bioorganic & Medicinal Chemistry Letters, 2012, 22: 6377-6380
20.Jing Han, Chang-Jiu Ji, Wen-Jun He, Yu Shen, Ying Leng, Wen-Yan Xu, Jun-Ting Fan, Guang-Zhi Zeng, Ling-Dong Kong, Ning-Hua Tan*. Cyclopeptide alkaloids from Ziziphus apetala. Journal of Natural Products, 2011, 74: 2571-2575
21.Jun-Ting Fan, Bin Kuang, Guang-Zhi Zeng, Si-Meng Zhao, Chang-Jiu Ji, Yu-Mei Zhang, Ning-Hua Tan*. Biologically active arborinane-type triterpenoids and anthraquinones from Rubia yunnanensis. Journal of Natural Products, 2011, 74: 2069-2080
22.Grace GL Yue, Jun-Ting Fan, Julia KM Lee, Guang-Zhi Zeng, Tina WF Ho, Kwok-Pui Fung, Ping-Chung Leung, Ning-Hua Tan*, Clara BS Lau*. Cyclopeptide RA-V inhibits angiogenesis by down-regulating ERK1/2 phosphorylation in HUVEC and HMEC-1 endothelial cells. British Journal of Pharmacology, 2011, 164: 1883-1898
23.Yan Shen, Qiong Luo, Hui-Min Xu, Gang-Yuan Gong, Xiao-Bin Zhou, Yang Sun, Xue-Feng Wu, Wen Liu, Guang-Zhi Zeng, Ning-Hua Tan*, Qiang Xu*. Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis. Biochemical Pharmacology, 2011, 82: 260-268
24.Yi-Shan Chen, Xu-Lin Pan, He Yan, Ning-Hua Tan*. Multiple hydrogen-bonding interactions between macrocyclictriurea and F-, Cl-, Br-, I- and NO3-: A theoretical investigation. Physical Chemistry Chemical Physics, 2011, 13(16): 7384-7395
25.Jun-Ting Fan, Yi-Shan Chen, Wen-Yan Xu, Liangcheng Du, Guang-Zhi Zeng, Yu-Mei Zhang, Jia Su, Yan Li, Ning-Hua Tan*. Rubiyunnanin A and B, two novel cyclic hexapeptides from Rubia yunnanensis. Tetrahedron Letters, 2010, 51: 6810-6813
26.Jun-Ting Fan, Jia Su, Yan-Min Peng, Yan Li, Jia Li, Yu-Bo Zhou, Guang-Zhi Zeng, He Yan, Ning-Hua Tan*. Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kB activation. Bioorganic & Medicinal Chemistry, 2010, 18: 8226-8234
27.Jun Tang, Conan K. Wang, Xu-Lin Pan, He Yan, Guang-Zhi Zeng, Wen-Yan Xu, Wen-Jun He, Norelle L. Daly, David J. Craik*, Ning-Hua Tan*. Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides, 2010, 31: 1434-1440
28.He Yan, Xu-Lin Pan, Ning-Hua Tan*, Jun-Ting Fan, Guang-Zhi Zeng, Hong-Jin Han. 2D- and 3D-QSAR studies on 54 anti-tumor Rubiaceae-type cyclopeptides. European Journal of Medicinal Chemistry, 2009, 44: 3425-3432
29.Wang, C. K., Hu, S. H., Martin, J. L., Sjogren, T., Hajdu, J., Bohlin, L., Claeson, P., Goransson, U., Rosengren, K. J., Tang, J., Tan, N. H., Craik, D. J*. Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. Journal of Biological Chemistry, 2009, 284(16): 10672-10683
30.Wen-Yan Xu, Jun Tang, Chang-Jiu Ji, Wen-Jun He, Ning-Hua Tan*. Application of a TLC chemical method to detection of cyclotides in plants. Chinese Science Bulletin, 2008, 53(11): 1671-1674
31.Yu-Mei Zhang, Ning-Hua Tan*, Yang Lu, Ying Chang, Rui-Rui Jia. Chamobtusin A, a novel skeleton diterpenoid alkaloid from Chamaecyparis obtuse cv. tetragon. Organic Letters, 2007, 9: 4579-4581
32.Ning-Hua Tan* and Jun Zhou. Plant cyclopeptides. Chemical Reviews, 2006, 106: 840-895

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