2009年博士毕业于中科院上海神经科学研究所

2018-2019，在美国南加州大学Alzheimer Disease Center任职副研究员

主持参与多项神经退行疾病相关药物研发项目，获得多个奖项

1. US patent （E-061-2019-0-US-01）：
Sima J* and Schlessinger D. Identification of lead compounds targeting LRP1-mediated Ab clearance. 2019.（* First /Submitting inventor）

2. Sima J*，Jian Zhu， Juxian Wang and Schlessinger D. Chemical inhibitors of LRP1 protein complexes promotes amyloid-beta clearance. Submitted (* Corresponding author)
3. Sima J* , Yan Z, Chen Y, Lehrmann E, Zhang Y, Nagaraja R, Wang W, Wang Z, Schlessinger D*. Eda-activated RelB recruits a SWI/SNF (BAF) chromatin remodeling complex and initiates gene transcription in skin appendage formation. PNAS. 2018,115 (32) 8173-8178 (* Corresponding author)
4. Sima J*, Yulan Piao, Yaohui Chen and David Schlessinger*. Molecular dynamics of Dkk4 modulates Wnt action and regulates Meibomian gland development. Development. 2016, Dec 15;143(24):4723-4735. (* Corresponding author)
5. Chen, G.*, Sima, J.*, Jin, M.*, Wang, K., Xue, X., Zheng, W., Ding, Y., and Yuan, X. Semaphorin-3A guides radial migration of cortical neurons during development. Nat. Neurosci. 2008, 11: 36-44. (*: Co-first author)
6. Xu D, Shen W, Guo R, Xue Y, Peng W, Sima J, Yang J, Sharov A, Srikantan S, Yang J, Fox D 3rd, Qian Y, Martindale JL, Piao Y, Machamer J, Joshi SR, Mohanty S, Shaw AC, Lloyd TE, Brown GW, Ko MS, Gorospe M, Zou S, Wang W. Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation. Nat. Neurosci. 2013, 16(9):1238-47.
7. Cui CY, Yin M, Sima J, Childress V, Michel M, Piao Y, Schlessinger D. Involvement of Wnt, Eda and Shh at defined stages of sweat gland development. Development. 2014 Oct;141(19):3752-60.

以第一发明人获得一项美国专利