2001-2005南京大学生物科学专业学士

2005-2010南京大学生物学博士

2010-2017 中国药科大学药学院药物化学系讲师 2017-至今中国药科大学药学院药物化学系副教授 2015-2016University of Colorado Boulder访问学者

作为项目负责人主持国家自然科学基金青年基金1项，教育部博士点新教师基金1项，江苏省自然科学基金面上项目1项，横向开发项目2项

.Fan-Wei Peng, Da-Ke Liu, Qing-Wen Zhang, Yun-Gen Xu*, Lei Shi*. VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016). Expert Opin. Ther. Pat., 2017, 27(9), 987-1004.

2.Fan-Wei Peng, Ji Xuan, Ting-Ting Wu, Jia-Yu Xue, Zi-Wei Ren, Da-Ke Liu, Xiu-Qi Wang, Xin-Hang Chen, Jia-Wei Zhang, Yun-Gen Xu*, Lei Shi*. Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC. Eur. J. Med. Chem., 2016, 109, 1-12.

3.Fan-Wei Peng, Ting-Ting Wu, Zi-Wei Ren, Jia-Yu Xue, Lei Shi*. Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase. Bioorg. Med. Chem. Lett., 2015, 25, 5137-5141.

4.Lei Shi*, Ting-Ting Wu, Zhi Wang, Jia-Yu Xue, Yun-Gen Xu*. Discovery of N-(2-phenyl-1H-benzo[d]imidazol-5-yl)quinolin-4-amine derivatives as novel VEGFR-2 kinase inhibitors. Eur. J. Med. Chem., 2014, 84, 698-707.

5.Lei Shi*, Ting-Ting Wu, Zhi Wang, Jia-Yu Xue, Yun-Gen Xu*. Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2. Bioorg. Med. Chem.,2014, 22(17), 4735-4744.

6.Zhi Wang, Yi-Qiao Fan, Lei Shi*, Yun-Gen Xu*. Synthesis, crystal structure, and biological activities of a Zn(II) complex with a Se substituted Schiff base. J. Coord. Chem.,2013, 66(11), 2032-2038.

7.Lei Shi*, Lu Wang, Zhi Wang, Hai-Liang Zhu*, Qiao Song.Synthesis of novel cinnamanilides as potential immunosuppressive agents. Eur. J. Med. Chem., 2012, 47, 585-593.