教育背景
2001年毕业于山东大学药学院药学专业,2007 获中国药科大学药物化学专业博士学位。
工作经历
现任职药物科学研究院新药研究中心,
项目课题经历
1. 苦瓜多肽类似物的分子构建、降糖活性和作用机制研究国家自然科学基金面上项目,81273376, 2013/01-2016/12,主持
2. 胰高血糖素样肽-1—香豆素类缀合长效衍生物的合成、生物活性及作用机制研究 国家自然科学基金面上项目,81172932, 2012/01-2015/12 ,参与
3. 新型肿瘤多药耐药逆转剂HZ08与P-糖蛋白结合模式及转运机制研究 国家自然科学基金面上项目,81173088,2012/01-2015/12 ,参与
4. 苦瓜多肽类似物的分子构建、降糖活性和作用机制研究江苏省自然科学基金青年项目,BK2012356, 2012/07-2015/05, 主持
5. 复星医药技术创新战略联盟项目新药创制重大专项,2010ZX09401-401, 2010/01-2013/12, 参与
论文、成果、著作等
1.Xin Deng, Qianqian Qiu, Baowei Yang, Xuekun Wang, Wenlong Huang* , Hai Qian*. Design, synthesis and biological evaluation of novel peptides with anti-cancer and drug resistance-reversing activities. European Journal of Medicinal Chemistry, 2015, 89(1), 540–548.
2.Xuekun Wang, Tianxiao Zhao, Baowei Yang, Zheng Li, Jian Cui, Yuxuan Dai, Qianqian Qiu,Hao Qiang, Wenlong Huang*, Hai Qian*. Synthesis and biological evaluation of Phenoxyacetic acid Derivatives as Novel Free Fatty Acid Receptor 1 Agonists. Bioorganic & Medicinal Chemistry, 2015,23 (1), 132–140.
3.Lei Jiao, Qianqian Qiu, Baomin Liu, Tianxiao Zhao, Wenlong Huang*, Hai Qian*. Design, synthesis and evaluation of novel triazole core based P-glycoprotein-mediated multidrug resistance reversal agents. Bioorganic & Medicinal Chemistry , 2014, 22 (24) 6857–6866.
4.Jing Han, Lidan Sun, Xun Huang, Zheng Li, Chenyu Zhang, Hai Qian* and Wenlong Huang*. Novel coumarin modified GLP-1 derivatives with enhanced plasma stability and prolonged in vivo glucose-lowering ability. British Journal of Pharmacology,2014,171 (23) 5252–5264.
5. Baowei Yang, Yicheng Mei, Xuekun Wang, Xin Deng, Hai Qian*, Wenlong Huang*. Design, synthesis and biological evaluation of novel peptide MC62 analogues as potential antihyperglycemic agents. European Journal of Medicinal Chemistry, 2014, (73),105-111.
6. Baomin Liu, Qianqian Qiu, Tianxiao Zhao,Lei Jiao, Jianyu Hou, Yunman Li, Hai Qian* and Wenlong Huang* Discovery of Novel P-Glycoprotein-Mediated Multidrug Resistance Inhibitors Bearing Triazole Core via Click Chemistry. Chem Biol Drug Des, 2014, 84(2), 182–191.
7. Jing Han, Lidan Sun, Yingying Chu, Zheng Li, Dandan Huang, Xiaoyun Zhu, Hai Qian*, Wenlong Huang*. Design, Synthesis and Biological activity studies of Novel Dicoumarin-Glucagon-Like Peptide-1 Conjugates. Journal of Medicinal Chemistry, 2013,56(24), 9955-9968.
8. Jing Han, Xun Huang, Lidan Sun, Zheng Li, Hai Qian*, Wenlong Huang*, Novel fatty chain-modified glucagon-like peptide-1 conjugates with enhanced stability and prolonged in vivo activity. Biochemical Pharmacology, 2013, 86(2), 297-308.
9. Baowei Yang, Wei Chen, Jing Jin, Yicheng Mei, Xuekun Wang, Hong Chen, Sijia Yan, Meng Ru, Guolong Gu, Xin Deng, Hai Qian* and Wenlong Huang*,Evaluation of Hypoglycemic and Antioxidative Effects of Synthesized Peptide MC62. Chem Biol Drug Des, 2013, 82(1), 99–105.
10. Chunlei Tang, Shu Chen, Hai Qian* and Wenlong Huang*. Interleukin-23: as a drug target for autoimmune inflammatory diseases. Immunology, 2012, 135(2), 112–124.
专利、著作版权等
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