教育背景
1993,9-1997,7:中国药科大学,药物化学,学士
1997,9-2000,7:中国药科大学,药物化学,硕士
2000,9-2003,7:中科院上海有机化学研究所,有机化学,博士
工作经历
2003,11-2007,11:美国国家健康研究院(NIH)癌症研究所(NCI);药物化学,博士后
2007,12-2016,12:中科院广州生物与健康研究院,药物化学,博士生导师, 课题组组长。
2017,1-现在:中国药科大学,药物化学,博士生导师, 课题组组长。
项目课题经历
具有干细胞调控活性的化合物及衍生物的合成
2009CB940904
主持
2009.1-
2013.12
690万
973项目子课题
2
番荔枝内酯简化类似物AA-005作为抗癌药物的研究
2009ZX09103-101
主持
2009.1-
2010.12
126万
国家新药创制重大专项
3
组蛋白去乙酰化酶抑制剂Lar-7的构效关系及其抗肿瘤活性的研究
21172220
主持
2012.1-
2015.12
60万
国家自然科学基金
面上项目
4
Argyrin A 的全合成研究
20972160
主持
2010.1-
2012.12
35万
国家自然科学基金
面上项目
5
蛋白裂解酶环肽抑制剂及其抗肿瘤活性研究
20802078
主持
2009.1-
2011.12
18万
国家自然科学基金
青年基金
6
蛋白裂解酶环肽抑制剂的设计与合成
NNCAS-2008-8
主持
2009.1-
2010.12
50万
诺华诺德-中科院联合基金
7
蛋白裂解酶抑制剂及其抗肿瘤活性研究
KSCX2-YW-R-215
主持
2010.1-
2010.12
20万
中国科学院知识创新工程重要方向项目
8
蛋白裂解酶小分子抑制剂的设计与合成
8151066302000008
主持
2009.1-
2011.12
5万
广东省自然科学基金
9
Flueggines A and B的全合成研究
21472191
主持
2015.1-
2018.12
90万
国家自然科学基金
面上项目
10
AA-005作为抗癌药物的研究
2013A022100019
参与
2015.1-
2017.12
150万
广东省新药创制专项
11
组蛋白去乙酰化I型酶的分子探针的构建及其早期诊治效果的研究
2016A050502036
主持
2016.1-
2018.12
50万
广东省国际合作专项
12
组蛋白去乙酰化I型酶的分子探针作为肿瘤早期诊治的研究
主持
2017.5-
2020.4
100万
广州市产学研协同创新重大专项
论文、成果、著作等
1. J. Bai, , C. Liao, D. Qin, Y. Liu, X. Qing, J. Chen, Z. Li, Z. Tu, S. Jiang.* Structure-Based Design of Potent Nicotinamide Phosphoribosyltransferase Inhibitors with Promising In Vitro and in Vivo Antitumor Activities. J. Med. Chem. 2016, 59, 5766-5779.
2. N. Ma, Y. Luo, Y. Wang, C. Liao, W.-C. Ye*, S. Jiang*. Selective histone deacetylase inhibitors with anticancer activity. Curr. Top. Med. Chem. 2016, 16, 415-426.
3. Y. Jin, Y. Yao, L. Chen, X. Zhu, B. Jin, Y. Shen, J. Li, X. Du, Y. Lu, S. Jiang*, J. Pan*. Depletion of γ-catenin by Histone Deacetylase Inhibition Confers Elimination of CML Stem Cells in Combination with imatinib. Theranostics. 2016, 6, 1947-1962.
4. Y. Yao, Z. Tu, C. Liao, Z. Wang, S. Li, H. Yao, Z. Li, S. Jiang*. Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro Selectivity for Cancers Cells and in Vivo Antitumor Activities. J. Med. Chem. 2015, 58, 7672-7680.
5. Y. Yao, Z. Li, Y. Qiu, J. Su, S. Jiang*. Unprecedented reactions: from epichlorohydrin to epoxyglycidyl substituted divinyl ether and its conversion into epoxyglycidyl propargyl ether. Scientific Reports. 2015, 5, srep14231.
6. N. Ma, Y. Wang, B. Zhao, W.-C. Ye*, S. Jiang*. The application of click chemistry in the synthesis of agents with anticancer activity. Drug Design, Development and Therapy. 2015, 50, 1585-1599.
7. J. Zhang, H. Zhou, S. Jiang, J. Jin, W. Li, W. Wang, S. Su. AA092, an annonaceous acetogenin mimetic, attenuates angiogenesis in a mouse model of inflammation-induced corneal neovascularization. International Immunopharmacology. 2015, 28, 997-1002.
8. Y. Zhou, G. Hou, S. He, Z. Xiao, H. Xu, Y. Qiu, S. Jiang, H. Zheng, Z. Li. Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells. CNS Neuroscience & Therapeutics. 2015, 21, 558-567.
9. N. Ma, Y. Yao, B.-X. Zhao, Y. Wang, W.-C. Ye*, S. Jiang*. Total synthesis of securinega alkaloids (-)-norsecurinine, (-)-niruroidine and (-)-flueggine A. Chem. Commun. 2014, 50, 9284-9287.
10. X. Zhu, L. Chen, S. Jiang, C. Chen, Y. Yao, D. Chen, H. Xue, J. Pan *. PQJS380: a novel lead compound to induce apoptosis in acute lymphoblastic leukemia cells. Cancer Biology & Therapy. 2014, 15, 119-127.
11. J. Su, Y. Qiu, S. Jiang*, D. Zhang*. New Ligands for Copper-Catalyzed C[n.63743]N Coupling Reactions at Gentle Temperature. Chinese Journal of Chemistry. 2014, 32(8), 685-688.
12. J. Su, Y. Qiu, K. Ma, Y. Yao, Z. Wang, X. Li, D. Zhang, Z. Tu, S. Jiang*. Design, synthesis, and biological evaluation of largazole derivatives: alteration of the zinc-binding domain. Tetrahedron. 2014, 70, 7763-7769.
13. H. Zhou, S. Jiang, J. Chen, X. Ren, J. Jin, S. B. Su*. Largazole, an inhibitor of class I histone deacetylases, attenuates inflammatory corneal neovascularization. European Journal of Pharmacology. 2014, 740, 619-626.
14. H. Zhou, S. Jiang, J. Chen, S. B. Su*. Suberoylanilide hydroxamic acid suppresses inflammation-induced neovascularization. Can. J. Physiol. Pharmacol. 2014, 92, 879-885.
15. Y. Liu, Y. Liu, Z. Liu, G. Zhou, Z.-J. Yao*, S. Jiang*. Identification of novel bivalent mimetics of annonaceous acetogenins via a scaffold-hopping strategy. Bioorg. Med. Chem. Lett. 2014, 24, 1650-1653.
16. Y. Liu, Q. Xiao, Y. Liu, Z. Li, Y. Qiu, G.-B. Zhou, Z.-J. Yao, S. Jiang*. Biological evaluation of new mimetics of annonaceous acetogenins: alteration of right scaffold by click linkage with aromatic functionalities. Eur. J. Med. Chem. 2014, 78, 248-258.
17. Y. Yao, C. Liao, Z. Li, Z. Wang, Q. Sun, C. Liu, Z. Tu*, S. Jiang*. Design, Synthesis, and Biological Evaluation of 1, 3-Disubstituted-Pyrazole Derivatives as New Class I and IIb Histone Deacetylase Inhibitors. Eur. J. Med. Chem. 2014, 86, 639-652.
18. Y. Zhao, X. Fang, Y. Wang, J. Zhang, S. Jiang, Z. Liu, Z. Ma, L. Xu, E. Li, K. Zhang. Comprehensive Analysis for Histone Acetylation of Human Colon Cancer Cells Treated with a novel HDAC Inhibitor. Current Pharmaceutical Design. 2014, 20, 1866-1873.
19. D. Zou, Y. Qiu, Z. Tu, C. Liao, J. Luo, Q. Meng, R. Yao, Z. Li, S. Jiang*.. Biological evaluation of 2-methylpyrimidine derivatives as active pan Bcr-Abl inhibitors. Science China: Chemistry. 2014, 57, 823-832.
20. Q. Meng, F. Li, S. Jiang, Z. Li*. Novel 64Cu-labeled CUDC-101 for in vivo PET Imaging of histone deacetylases. ACS Medicinal Chemistry Letters. 2013, 4, 858-862.
21. L. Wu, Z. Wen, Y. Qiu, X. Chen, H. Chen, M. Wei, Z. Liu, S. Jiang*, G. Zhou*. Largazole arrests cell cycle at G1 phase and triggers proteasomal degradation of E2F1 in lung cancer cells; ACS Medicinal Chemistry Letters. 2013, 4, 921-926.
22. Y. Yao, H. Yao, S. Jiang*, X. Xue*. Progress in clinical study of histone deacetylase inhibitors as anticancer agents; Chinese J New Drugs. 2013, 22 (3), 1-7.
23. Q. Sun , Y. Yao, C. Liu, H. Li, H. Yao, X. Xue, J. Liu, Z. Tu*, S. Jiang*. Design, Synthesis, and Biological Evaluation of Novel Histone Deacetylase 1 Inhibitors through click chemistry. Bioorg. Med. Chem. Lett. 2013, 23, 3295-3299.
24. X. Li, Z. Tu, H. Li, C. Liu, Z. Li, Q. Sun, Y. Yao, J. Liu, S. Jiang*. Biological evaluation of new largazole analogues: Alteration of macrocyclic scaffold with Click chemistry; ACS Medicinal Chemistry Letters. 2013, 4, 132-136.
25. Y. Qiu, W. Jia, Z. Yao, F. Wu, S. Jiang*. 2-Carbomethoxy-3-hydroxyquinoxaline-di-N-oxide as a novel ligand for the copper-catalyzed coupling reaction of phenols and aryl halides. Organic & Biomolecular Chemistry. 2013, 11, 1502-1510.
26. Yang, Mei; He, Jiangbo; Cheng, Yongxian; Jiang, Sheng*. Synthesis of 3-[(Z)-pentadec-8-enyl]catechol and its anti-angiogenesis activity. Chinese Journal of Organic Chemistry. 2013, 33(6), 1319-1325.
27. D. Che, K. Yang, H. Xiang, S. Jiang*. New ligands for copper-catalyzed C-N coupling reactions with aryl halides; Tetrahedron Letters. 2012, 53, 7121-7124.
28. Y. Liu, X. Cheng, L. Guo, C. Mao, Y. Chen, H. Liu, Q. Xiao, S. Jiang, Z. Yao, G. Zhou. Identification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cells; PLoS One. 2012, 7, e47049.
29. K. Su, Y. Qiu,; Y. Yao,; D. Zhang, S. Jiang*. 8-hydroxyquinolin-N-oxide-promoted copper-catalyzed C-S cross-coupling of thiols with aryl iodides; Synlett. 2012, 23, 2853-2857.
30. Q. Xiao, Y. Liu, Y. Qiu, G. Zhou, C. Mao, Z. Li, Z.-J. Yao*, S. Jiang*. Potent Antitumor Mimetics of Annonaceous Acetogenins Embedded with an Aromatic Moiety in the Left Hydrocarbon Chain Part; J. Med. Chem. 2011, 54, 525-533.
31. K. Yang, Y. Qiu, Z. Li, Z. Wang, S. Jiang*, Ligands for Copper-Catalyzed C- N Bond Forming Reactions with 1 Mol% CuBr as Catalyst. J. Org. Chem, 2011, 76, 3151-3159.
32. Y. Qiu, Y. Liu, K. Yang, W. Hong, Z. Li, Z. Wang, S. Jiang*. New Ligands That Promote Cross-Coupling Reactions between Aryl Halides and Unactivated Arenes. Org. Letters, 2011, 13, 3556-3559.
33. K. Yang, Z. Li, Z. Wang, S. Jiang*. Highly Efficient Synthesis of Phenols by Copper-Catalyzed Hydroxylation of Aryl Iodides, Bromides, and Chlorides. Org. Letters, 2011, 13, 4340-4343.
34. W. Wu, Z. Li, G. Zhou, S. Jiang*. Total synthesis of argyrins A and E. Tetrahedron. Lett. 2011, 52, 2488-2491.
35. Z. Yao, X. Zeng, W. Yi, S. Jiang*. Stereoselective Synthesis of (S,E)-2-(trimethylsilyl)ethyl 3-hydroxy-7-(tritylthio) hept-4-enoate. Letters in Organic Chemistry, 2011, 8, 66-69.
36. Q. Xiao, Y. Liu, Y. Qiu, Z. Yao, G. Zhou, Z.-J. Yao*, S. Jiang*. Design, synthesis of symmetrical bivalent mimetics of annonaceous acetogenins and their cytotoxicities. Bioorg. Med. Chem. Lett. 2011, 21, 3613-3615.
37. S. Li, H. Yao, J. Xu*, S. Jiang*. Synthetic Routes and Biological Evaluation of Largazole and Its Analogues as Potent Histone Deacetylase Inhibitors. Molecules, 2011, 16, 4681-4694.
38. L. Johannessen, J. Remsberg, V. Gaponenko, K. M. Adams, J. J. Barchi, S. G. Tarasov, S. Jiang, N. I. Tarasova. Peptide Structure Stabilization by Membrane Anchoring and its General Applicability to the Development of Potent Cell-Permeable Inhibitors. ChemBioChem. 2011, 12, 914-921.
39. Z. Yao, Y. Xu, M. Zhang, S. Jiang, M. C. Nicklaus, C. Liao. Discovery of a novel hybrid from finasteride and epristeride as 5a-reductase inhibitor. Bioorg. Med. Chem. Lett, 2011, 21, 475-478.
40. W. Hong, Y. Qiu, Z. Yao, Z. Wang, S. Jiang*. Palladium-Catalyzed Direct C–H Arylation of Unactivated Arenes with Aryl Halides. Tetrahedron. Lett. 2011, 52, 4916-4919.
41. X. Zeng, W. Huang, Y. Qiu, S. Jiang*. Efficient Copper-Catalyzed Synthesis of Anilines by Employing Aqueous Ammonia. Organic & Biomolecular Chemistry. 2011, 9, 8224-8227.
42. Y. Xu, F. Wu, Z. Yao, S. Jiang. Synthesis of quinoxaline 1,4-di-N-oxide analogues and crystal structure of 2-carbomethoxy-3-hydroxyquinoxaline-di-N-oxide. Molecules, 2011, 6894-6901.
43. X. Zeng, B. Yin, Z. Hu, C. Liao, Z. Li, G. Zhou*, S. Jiang*.Total Synthesis and Biological Evaluation of Largazole and Derivatives with Promising Selectivity for Cancers Cells. Orgainc. Lett. 2010, 12, 1368-1371.
44. J. Zheng, B. Yin, W. Huang, X. Li, H. Yao, Z. Liu, S. Jiang*. Efficient and selective cleavage of the t-butoxycarbonyl group from di-t-butylimidodicarbonate using catalytic bismuth (III) bromide in acetonitrile. Tetrahedron. Lett. 2009, 50, 5094-5097.
45. S. Jiang*, C. Liao, L. Bindu, B. Yin, K. W. Worthy, R. J. Fisher, T. R. Burke, Jr., M. C. Nicklaus, P. P. Roller. Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity. Bioorg. Med. Chem. Lett. 2009, 19, 2693-2698.
46. Z. Nikolovska-Coleska, J. Meagher, S. Jiang, C. Yang, S. Qiu, P. P. Roller, J. Stuckey, S. Wang. Interaction of a Cyclic, Bivalent Smac Mimetic with the X-Linked Inhibitor of Apoptosis Protein. Biochemistry. 2008, 47, 9811-9824.
47. S. Jiang*, Z. Li, K. Ding, P. P. Roller. Recent Progress of Synthetic Studies to Peptide and Peptidomimetic Cyclization. Current Organic Chemistry. 2008, 12, 1502-1542.
48. Z. Nikolovska-Coleska, J. Meagher, S. Jiang, S. A. Kawamoto, W. Gao, H. Yi, D. Qin, P. P. Roller, J. Stuckey, S. Wang. Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains. Anal Biochem. 2008, 374, 87-98.
49. O. A. Timofeeva, V. Gaponenko, S. J. Lockett, S. G. Tarasov, S. Jiang, C. J. Michejda, A. O. Perantoni, N. I. Tarasova. Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target. ACS Chem Biol. 2007, 2, 799-809.
50. S. Jiang, P. Li, S. L. Lee, C. Y. Lin, Y.Q Long, M. D. Johnson, R. B. Dickson, P. P. Roller. Design and Synthesis of redox stable analogues of Sunflower Trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of Matriptase. Orgainc. Lett. 2007, 9, 9-12.
51. H-X. Liu, G-R. Huang, H-M Zhang, S. Jiang, J.-R. Wu, Z. -J. Yao. A Structure-Activity Guided Strategy for Fluorescent Labeling of Annonaceous Acetogenin Mimetics and their Application in Cell Biology. ChemBioChem. 2007, 8, 172-177.
52. P. Li, S. Jiang, S. L. Lee, C. Y. Lin, M. D. Johnson, C. J. Michejda, R. B. Dickson, P. P. Roller. Synthesis and evaluation of analogs of SFTI-1, potent inhibitors of the Type II transmembrane serine protease, Matriptase. J. Med. Chem. 2007, 50, 5976-5983.
53. P. Li, S. Jiang, P. C. Stephanie, O. Lyn, D. N. Krag, P. P. Roller. Design and Synthesis of Water-Soluble Conjugates of Paclitaxel to Extracellular Doma in of ErbB2-Recognizing Peptide. Biopolymers. 2007, 87, 225-230.
54. H. Sun, Z. Nikolovska-Coleska, J. Lu, J. Meagher, C. Yang, S. Qiu, Y. Tomita, Y. Ueda, S. Jiang, Krajewski, P. P. Roller, J. A. Stuckey, S. Wang. Design, Synthesis and Characterization of A Potent, Non-Peptide, Cell-Permeable, Bivalent Smac Mimetic that Concurrently Targets both the BIR2 and BIR3 Domains in XIAP. J. Am. Chem. Soc. 2007, 129, 15279-15294.
55. G. Z. Tang, C. Y. Yang, Z. Nikolovska-Coleska, J. Guo, S. Qiu, R. X. Wang, W. Gao, G. P. Wang, J. Stuckey, K. Krajewski, S. Jiang, P. P. Roller, S. Wang. Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins. J. Med. Chem. 2007, 50, 1723-1726.
56. G. Z. Tang, K. Ding, Z. Nikolovska-Coleska, C. Y. Yang, S. Qiu, S. Shangary, R. X. Wang, J. Guo, W. Gao, J. Meaghe, J. Stuckey, K. Krajewski, S. Jiang, P. P. Roller, S. Wang. Structure-Based Design of Flavonoid Compounds As a New Class of Small-Molecule Inhibitors of the Anti-apoptotic Bcl-2 Proteins. J. Med. Chem. 2007, 50, 3163-3166.
57. J. Chen, Z. Nikolovska-Coleska, C. Y. Yang, C. Gomez, W. Gao, K. Krajewski, S. Jiang, P. P. Roller, S. Wang. Design and synthesis of a new, conformationally constrained, macrocyclic small-molecule inhibitor of STAT3 via ‘click chemistry’. Bioorg. Med. Chem. Lett. 2007, 17, 3939-3942.
58. S. Jiang, P. Li, C. C. Lai, J.A. Kelley, P. Roller. Design and Practical Synthesis of Fully Protected analogs of L-γ-Carboxyglutamic Acid. J. Org. Chem. 2006, 71, 7307-7314.
59. S. Jiang, P. Li, M. Peach, R. J. Fisher, T. R. Burke, M. Nicklaus, P. P. Roller. Structure-based design of potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics. Biochem. Biophys. Res. Commun. 2006, 349, 497-503.
60. S. Jiang, C. C. Lai, J. A. Kelley, P. P. Roller. A Practical Synthesis of Fully Protected L-γ-Carboxyglutamic Acid (L-Gla). Tetrahedron. Lett. 2006, 47, 23-25.
61. G. P. Wang, Z. Nikolovska-Coleska, C. Y. Yang, R. X. Wang, G. Z. Tang, J. Guo, S. Shanggary, S. Qiu, W. Gao, D. J. Yang, J. Meagher, J. Stuckey, K. Krajewski, S. Jiang, P. P. Roller, H.O. Abbaan, Y. Tomita, S. Wang. Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J. Med. Chem. 2006, 49, 6139-6142.
62. Y. Zhao, S. Jiang, Y. W. Guo, Z.-J. Yao. Synthesis of two naturally occurring 4-hydroxylated butenolides with PTP1B inhibitory activity. Chinese. J. Chem. 2005, 23, 173-175.
63. S. Jiang, Y. Li, X. G. Chen, T. S. Hu, Y. L. Wu, Z.-J. Yao. Parallel fragment assembly strategy towards multiple-ether mimicry of anticancer annonaceous acetogenins. Angew. Chem. Int. Ed. 2004, 43, 329-334.
64. G. R. Huang, S. Jiang, Y. L. Wu, Z. J. Yao, J.R. Wu. Induction of cell death of gastric cancer cells by a modified compound of the annonaceous acetogenin family. Chem BioChem 2003, 4, 1216-1221.
65. B.B. Zeng, Y.K. Wu, S. Jiang, Q. Yu, Z.J. Yao, Z. Liu, H. Li, Y. Li, X. Chen, Y.L. Wu. Studies on Mimicry of Naturally occuring Annonaceous Acetogenins: Non-THF Analogues Leading to Remarkable Selective Cytotoxicity Against Human Tumor cells. Chem. Eur. J. 2003, 9, 282-290.
66. S. Jiang, Y.L. Wu, Z.J. Yao. Synthesis of A Mimicking Hybrid of Annonaceous acetogenin with Steroid for considerable Antitumor Activity Investigation. Chinese J. Chem. 2002, 20, 1393-1400.
67. S. Jiang, Y.L. Wu, Z.J. Yao. First Synthesis of Mosquito larvicidal Butenolides I and II. Chinese J. Chem. 2002, 20, 692-696.
68. S. Jiang, Z. Liu, G. Sheng, B. B. Zeng, X. G. Cheng, Y.L. Wu, Z.J. Yao. Mimicking of Annonaceous Acetogenins: Enantionselective Synthesis of a (4R)-Hydroxy Analog Having Potent Antitumor Activity. J. Org. Chem, 2002, 67, 3404-3408.
专利、著作版权等
1. “Synthesis and application of ether bond modified chiral annonaceous acetogenins compound”
Licensed to Shanghai Institute of Organic Chemistry
Inventors: Z. J. Yao, Y. L. Wu and S. Jiang.
Patent No. CN1477103
2. “Method for synthesis of largazole and its analogs as antitumor agents.”
Inventors: S. Jiang, G. Zhou, B. Yin, X. Zeng, and Z. Hu.
Patent No. CN 101781321
3. “Annonaceous acetogenins analogs as antitumor agents and their preparation, pharmaceutical compositions and use in the treatment of cancer”
Inventors: S. Jiang, Z.J. Yao, G. Zhou, Q. Xiao, Y. Liu
Patent No. CN 101982464
4. “Preparation of cyclopeptides as histone deacetylase inhibitors”
Inventors: S. Jiang, S. Li, Y. Yao, F. Zhang, Y. Chao, H. Ye, M. Chen
CN Patent Serial No. CN102391359
5. “Preparation of triazole compounds as histone deacetylase inhibitors.”
Inventors: S. Jiang, Z. Tu, Y. Yao, C. Liu, H. Yao, X. Xue,
Patent No. CN 102311398
6. “Process for preparation of FK228”
Inventors: S. Jiang, J. Xu, S. Li, H. Yao, X. Zeng, Y. Yao,
Patent No. CN 102276689
7. “Quinoxalinyl bis(N-oxide) derivatives and their application as ligands in Cu-catalyzed C-O coupling reaction”
Inventors: Z. Yao, S. Jiang,
Patent No. CN 102060790
8. “Quinoline derivative-N-oxide ligands, their preparation method and application in N-C coupling”
Inventors: Z. Yao, S. Jiang,
Patent No. CN 101899003
9. “Method for preparing epichlorohydrin tetramer and its reaction with formaldehyde derivative”
Inventors: D. Zhang, J. Su, S. Jiang,
Patent No. CN 103864727
10. “Preparation of largazole analog compounds as antitumor agents”
Inventors: S. Jiang, Z. Tu, X. Li, Y. Yao, Y. Qiu
Patent No. CN 103601742
11. “13-membered cyclic peptide as histone deacetylase inhibitor and its preparation”
Inventors: H. Xiang, G. Wang, S. Jiang, Z. Tu,
Patent No. CN 103232474
12. “Preparation of N-containing heterocyclic derivatives as histone deacetylase I inhibitor”
Inventors: S. Jiang, Z. Tu, Q. Sun, C. Liu, Y. Yao, Y. Qiu,
Patent No. CN 103086971
13. “Preparation of 3-(pyridin-3-yl)acrylamide derivatives as nicotinamide phosphoribosyltransferase inhibitors useful for the treatment of cancer”
Inventors: S. Jiang, Z. Tu, D. Zheng, D. Qin, J. Bai, X. Qin, Y. Yao, Y. Liu, Y. Qiu, J. Chen
Patent No. CN 104557863/PCT 090572
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