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江峰

领域:生物产业 学校:中国药科大学职称:副教授

1. 基于多样性导向合成方法,围绕生物活性类天然产物进行分子优化、虚拟筛选和体内外活性评价,推进具有临床应用潜力的自主新药研发;2. 探索“绿色化学合成技术”在药物合成中的应用,发展药物绿色合成新方法,开发药物绿色制造新工艺。近年主要从事抗肿瘤类天然产物分子设计、合成与构效关系,生物活性多肽的合成与纯化等方面的研究工作...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

1999.9-2003.7 武汉工程大学化工与制药学院制药工程专业,学士;
2004.9-2009.7 华南理工大学化学与化工学院化学工程专业,博士(硕博连读);

工作经历

2009.7-至今中国药科大学制药工程教研室任教; 2015.3-2016.3 美国加州大学洛杉矶分校(UCLA)化学与生物化学系Michael E. Jung教授实验室访问学者。

项目课题经历

1. 主持中央高校基本科研业务费专项资金重点项目(2632018ZD01)

2. 主持江苏省自然科学基金青年基金项目(BK20130648)

3. 主持天然药物活性组分与药效国家重点实验室优秀青年学者基金项目(JKGQ201112)

4. 主持中央高校基本科研业务费专项资金青年项目(JKQ2009007)

5. 主持中国药科大学人才引进项目(211146)

6. 参与国家重点研发计划项目(2018YFC0311003)

7. 参与国家重点研发计划项目(2017YFD0400402)

8. 参与国家自然科学基金面上项目(81573313)

9. 参与国家自然科学基金面上项目(20976060)

论文、成果、著作等

1. Jianming Liao, Linlin Wang, Zhongxi Wu, Zhixiang Wang, Jun Chen, Yucheng Zhong, Feng Jiang*, Yuanyuan Lu*. Identification of phenazine analogue as a novel scaffold for thioredoxin reductase I inhibitors against Hep G2 cancer cell lines. Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34(1): 1158-1163.

2. Meichen Zhang, Shuhui Gu, Guangpan Liu, Chencheng Li, Hanmei Xu*, Zhongxi Wu, Boping Ye, Yuanyuan Lu, Dechun Huang, Zhixiang Wang, Feng Jiang*. Facile synthesis and cytotoxicity of phenazine-chromene hybrid molecules derived from phenazine natural product. Combinatorial Chemistry & High Throughput Screening, 2019, 22(1): 35-40.

3. Jing Zhang, Qiming Wang, Zhonglin Zhu, Hongliang Qian, Feng Jiang, Zhixiang Wang, Wei Liu*, Dechun Huang*. Micronization of Gefitinib Using Solution‐Enhanced Dispersion by Supercritical CO2. Chemical Engineering & Technology, 2019, 42(2): 388-396.

4. Dechun Huang, Zhonglin Zhu, Qiming Wang, Beichen Qin, Lin Dai, Feng Jiang, Wei Liu*, Hongliang Qian*. Prediction model, experimental optimization, and verification for yield of high-pressure crystallization: a case study of citric acid. Separation Science and Technology, 2019, DOI: 10.1080/01496395.2018.1561717.

5. Hongliang Qian, Lin Dai, Feng Jiang, Yiqiang Shi, Zhixiang Wang, Wei Liu*, Dechun Huang*, Wei Chen. Quantitative Design of Seed Load Based on model identification of nucleation and crystal growth stages without transmittance data. Powder Technology. 2018, 335, 11-17.

6. Yuanyuan Lu, Yuru Yan, Linlin Wang, Xiaobing Wang, Jing Gao, Tao Xi, Zhixiang Wang, Feng Jiang*. Design, facile synthesis and biological evaluations of novel pyrano[3,2-a]phenazine hybrid molecules as antitumor agents. European Journal of Medicinal Chemistry. 2017, 127, 928-943.

7. Yuanyuan Lu*, Linlin Wang, Xiaobing Wang, Tao Xi, Jianmin Liao, Zhixiang Wang, Feng Jiang*. Design, combinatorial synthesis and biological evaluations of novel 3-amino-1′-((1-aryl-1H-1,2,3-triazol-5-yl)methyl)-2′-oxospiro[benzo[a] pyrano[2,3-c]phenazine-1,3′-indoline]-2-carbonitrile antitumor hybrid molecules. European Journal of Medicinal Chemistry. 2017, 135, 125-141.

8. Jing Gao, Ming Chen, Xue Tong, He Zhu, Hongbin Yan, Daichun Liu, Wanjing Li, Shengyu Qi, Dake Xiao, Yongzhi Wang, Yuanyuan Lu, Feng Jiang*. Synthesis, antitumor Activity, and structure-activity relationship of some benzo[a]pyrano[2,3-c]phenazine derivatives. Combinatorial Chemistry & High Throughput Screening, 2015, 18(10): 960-974.

9. Feng Jiang, Lin Dai, Yiqiang Shi, Zhixiang Wang*. A three-dimensional chiral crystal structure constructed from a chiral triazolate ligand showing an SrSi2 topology: poly[bis(μ3-3,5-diethyl-1,2,4-triazolato-κ3N1:N2:N4)trisilver nitrate]. Acta Crystallographica, Section C: Crystal Structure Communications.2013. C69, 1485-1487.

10. Feng Jiang, Yun Ling, Jinqing Qu*, Huanqin Chen. Synthesis and crystal structure of a novel chiral 1-methylpropargyl ester carrying azobenzene moiety. Chinese Journal of Structural Chemistry. 2010. 29(1): 146-150.

11. Feng Jiang, Jinqing Qu*, Huanqin Chen. Synthesis and properties of polyacetylenes containing carbazole and amino acid moieties. Chinese Journal of Polymer Science. 2009. 27(6): 789-796.

12. Feng Jiang, Jinqing Qu*, Huanqin Chen. Synthesis and characterization of poly(chiral methylpropargyl esters) carrying azobenzene moieties. Chinese Journal of Chemistry. 2009. 27(10): 2079-2084.

13. Jinqing Qu*, Feng Jiang, Huanqin Chen, Sanda Fumio, Masuda Toshio. Synthesis and photoisomerization of poly(1-methylpropargyl ester)s carrying azobenzene moieties. Journal of Polymer Science: Part A: Polymer Chemistry. 2009. 47(18): 4749-4761.

14. Jinqing Qu*, Feng Jiang, Huanqin Chen, Masuda Toshio. Synthesis and chiroptical properties of poly(methylpropargyl ester)s carrying ferrocene moieties. Journal of Macromolecular Science, Part A: Pure and Applied Chemistry. 2009. 46(2): 131-135.

15. 江峰, 王志祥, 瞿金清. 含天然产物侧基的取代聚乙炔的合成与性能. 高分子材料科学与工程. 2011, 27(6): 178-181.

16. 江峰, 王志祥, 史益强, 瞿金清. 新型咔唑取代乙炔化合物的合成与表征. 合成化学. 2011, 19(4):465-468.

17. 江峰, 凌云, 王志祥, 瞿金清. Synthesis of a acetylene derivative carrying carbazole and azobenzene groups. 化学研究与应用. 2011, 23(9): 1235-1239.

专利、著作版权等

1. 江峰, 闫玉茹, 陆园园, 奚涛, 刘代春, 王志祥, 邢莹莹. 一种吡喃并[3,2-a]吩嗪衍生物及其制备方法和用途. 中国发明专利,授权号2015108940700.
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