领域：生物产业 学校：复旦大学职称：副教授
主要利用微生物学、分子生物学、细胞生物学、免疫学等方法开展结核分枝杆菌感染致病的基础研究。主要包括(1)翻译后修饰调控结核杆菌感染致病的分子机制； (2)新型抗结核药物发现及其分子作用机制。目前在研项目包括国家自然科学基金面上项目（81673482）、上海市科技支撑项目（15431900200）及国家重点研发计划（2016YFA0500600）等。
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1. Jing Bi, Zongchao Gou , Fengzhu Zhou, Yiqing Chen, Jianhua Gan, Jun Liu, Honghai Wang and Xuelian Zhang* Acetylation of lysine 182 inhibits the ability of Mycobacterium tuberculosis DosR to bind DNA and regulate gene expression during hypoxia， Emerging Microbes & Infections，2018，7:108
2. Jing Bi#, Yihong Wang#, Heguo Yu, Xiaoyan Qian, Honghai Wang, Jun Liu*, Xuelian Zhang* Modulation of Central Carbon Metabolism by Acetylation of Isocitrate Lyase in Mycobacterium tuberculosis, Scientific Reports, 2017, 7:44826
3. Juanjuan Yang(#)，Yindi Liu，Jing Bi，Qixu Cai，Xinli Liao，Wenqian Li，Chenyun Guo，Qian Zhang，Tianwei Lin，Yufen Zhao，Honghai Wang，Jun Liu*，Xuelian Zhang*，Donghai Lin* Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide，Molecular Microbiology，2015，95（5）：791-803
4. Wanliang Shi，Xuelian Zhang，Xin Jiang，Haiming Yuan，Jong Seok Lee，Clifton E. Barry 3rd，Ying Zhang* Pyrazinamide Inhibits Trans-Translation inMycobacterium tuberculosis，Science，2011，333：1630-1632
5. Rusong Luo，Tuomo Laitinen，Liyan Teng，Tapio Nevalainen，Maija Lahtela-Kakkonen,，Baofu Zheng，Honghai Wang*，Antti Poso*，Xuelian Zhang*，Synthesis and Biological Evaluation of Arylthiourea Derivatives with Antitubercular Activity，Letters in Drug Design & Discovery，2013，10：640-650
6. Lina Shi，Haiping Zhang，Yu Qiu，Qian Wang，Xueji Wu，Honghai Wang，Xuelian Zhang*，Donghai Lin* Biochemical characterization and ligand-binding properties of trehalose-6-phosphate phosphatase from Mycobacterium tuberculosis，Acta Biochimica et Biophysica Sinica，2013，45（10）：837-844
