领域:生物产业 学校:复旦大学职称:副教授
出生缺陷发生的遗传学机制,尤其是叶酸代谢途径和平面细胞极性途径相关基因在先天性心脏病和神经管畸形发生过程中的作用。
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具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com
1. Yang XY*, Zhou XY*, Wang Q*, Li H, Chen Y, Lei YP, Ma XH, Kong P, Shi Y, Jin L, Zhang T, Wang HY. Mutations in the COPII Vesicle Component Gene SEC24B are Associated with Human Neural Tube Defects. Human Mutatation. 2013. doi: 10.1002/humu.22338. [Epub ahead of print].
2. Zhao JY*, Yang XY*, Shi KH*, Sun SN, Hou J, Ye ZZ, Wang J, Duan WY, Qiao B, Chen YJ, Shen HB, Huang GY, Jin L, Wang HY. A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population. Cell Research. 2013. 23(2): 242-253.
3. Zhao JY*, Yang XY*, Gong XH*, Gu ZY, Duan WY, Wang J, Ye ZZ, Shen HB, Shi KH, Hou J, Huang GY, Jin L, Qiao B, Wang HY. Functional Variant in Methionine Synthase Reductase Intron-1 Significantly Increases the Risk of Congenital Heart Disease in the Han Chinese Population. Circulation. 2012. 125 (3):482-490.
4. Rodrigues, F.S.*, Yang, X.*, Nikaido, M., Liu, Q. and Kelsh, R.N. A Simple, Highly Visual in Vivo Screen for Anaplastic Lymphoma Kinase Inhibitors. ACS Chemical Biology. 2012. 7 (12): 1968–1974.
5. Lopes SS*, Yang XY*, Muller J, Carney TJ, McAdow AR, Rauch GJ, Jacoby AS, Hurst LD, Delfino-Machin M, Haffter P, Geisler R, Johnson SL, Ward A, Kelsh RN. Leukocyte tyrosine kinase functions in pigment cell development. PLoS Genetics. 2008. 4:e1000026.