领域:生物产业 学校:复旦大学职称:副教授
结构生物学,化学生物学
通过结构生物学和化学生物学方法,研究神经退行性疾病相关靶蛋白与治疗性小分子及纳米抗体之间的作用机制,并开发相应的高灵敏特异性靶蛋白检测技术。
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具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com
1. H. Zhao, J. Zhao, J. Hou, S. Wang, Y. Ding*, B. Lu*, and J. Wang*, AlphaLISA detection of alpha-synuclein in the cerebrospinal fluid and its potential application in Parkinson's disease diagnosis. Protein Cell, 2017. 8(9):696-700.
2. J. Zhao, L. Xu, Q. Liang, Q. Sun, C. Chen, Y. Zhang, Y. Ding Y. Ding*, and P. Zhou*, EGCG attenuates Fe(III)-induced conformational transition of alpha-synuclein and protects AS-PC12 cells against Fe(III)-induced death. J Neurochem, 2017. 143(1):136-146.
3. R. Liu, X.J. Hu*, and Y. Ding*, Rational design of a pH-insensitive cyan fluorescent protein CyPet2 based on the CyPet crystal structure. FEBS Lett, 2017. 591(12): p. 1761-1769.
4. J. Zhao, Q. Liang, Q. Sun, C. Chen, L. Xu, Y. Ding*, and P. Zhou*, (−)-Epigallocatechin-3-gallate (EGCG) inhibits fibrillation, disaggregates amyloid fibrils of α-synuclein, and protects PC12 cells against α-synuclein-induced toxicity. RSC Adv, 2017. 7: p. 32508-32517 (12): p. 1761-176.
5. Liu, R., G. Yang, M.H. Zhou, Y. He, Y.A. Mei*, and Y. Ding*, Flotillin-1 downregulates K+ current by directly coupling with Kv2.1 subunit. Protein Cell, 2016. 7(6): p. 455-460.
6. Liu, R., Q.N. Liang, S.Q. Du, X.J. Hu*, and Y. Ding*, The crystal structure of red fluorescent protein TagRFP-T reveals the mechanism of its superior photostability. Biochem. Biophys. Res. Commun., 2016. 477(2): p. 229-234.
7. Liang, Q.N., R. Liu, S.Q. Du, and Y. Ding*, Structural insights on the catalytic site protection of human carbonyl reductase 1 by glutathione. J. Struct. Biol., 2015. 192(1): p. 138-144.
8. Cui, X.T., Q.N. Liang, Y.J. Liang, M.X. Lu, Y. Ding*, and B.X. Lu*, TR-FRET Assays of Huntingtin Protein Fragments Reveal Temperature and PolyQ Length-Dependent Conformational Changes. Sci Rep, 2014. 4.
9. Sun, P.F., Y. He, M.C. Lin, Y. Zhao, Y. Ding*, G.S. Chen*, and M. Jiang, Glyco-regioisomerism Effect on Lectin-Binding and Cell-Uptake Pathway of Glycopolymer-Containing Nanoparticles. ACS Macro Lett., 2014. 3(1): p. 96-101.