领域：生物产业 学校：复旦大学职称：教授
用生物化学、分子生物学、蛋白组学和生物信息学等手段, 研究代谢调控机理及代谢失调与人类疾病发生的关系。重点研究：1.代谢酶乙酰化修饰失调导致的人类疾病发病机理及及其新的干预手段2. 代谢中间体失调导致肿瘤的发生机理及干预手段。 目前已有系列论文发表在国际知名刊物上。目前在研项目包括国家973/863重大项目、国家自然科学基金重点项目、国家自然科学基金面上项目、上海市基础研究重点项目及复旦-GSK合作项目等。
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1. Wenqing Jiang， Shiwen Wang， Mengtao Xiao，Yan Lin， Lisha Zhou，Qunying Lei，Yue Xiong，Kun-Liang Guan and Shimin Zhao*. (2011) “Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase.” Molecular Cell 43，1-12 (IF=14.6)
2. Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim S, Ito S, Yang C, Wang P, Xiao M, Liu L, Jiang W, Liu J, Zhang J, Wang B, Frye S, Zhang Y, Xu Y, Lei Q, Guan K, Zhao S* and Y. Xiong. (2011) “Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α- ketoglutarate-dependent dioxygenases”. Cancer Cell 19, 17-30 (IF=26.9)
3. Qijun Wang, Yakun Zhang, Hui Xiong,Yan Lin, Hong Li, Lu Xie, Wei Zhao, YufengYao, Yue Xiong, Kun-Liang Guan, Shimin Zhao* and Guo-Ping Zhao (2010). “Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux”. Science 327, 2010, 1004-1008（IF：31.36）
4. Shimin Zhao, Wei Xu, Wenqing Jiang, Wei Yu, Yan Lin, Tengfei Zhang,Jun Yao, Pengyuan Yang, Hong Li, Yixue Li, Jiong Shi, Lunxiu Qin, Qunying Lei, Yue Xiong and Kun-Liang Guan (2010). “Regulation of Cellular Metabolism by Protein Lysine Acetylation”. Science 327, 2010, 1000-1004（IF：31.36）
5. Shimin Zhao,Yan Lin, Wei Xu, Wenqing Jiang, Zhengyu Zha, Pu Wang,Wei Yu,Zhiqiang Li, Lingling Gong, Yingjie Peng, Jianping Ding, Qunying Lei, Kun-Liang Guan, Yue Xiong. “Glioma-Derived Mutations in IDH1Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1a”. Science 2009, Vol 324, 261-265 （IF：31.36）
