领域:生物产业 学校:复旦大学职称:研究员
以斑马鱼为模式动物,利用遗传学、发育生物学和分子生物学的方法研究信号传导, 细胞分化和器官建成,建立人类疾病模型。目前研究方向为心血管系统和骨骼肌的发育和疾病,损伤和再生。
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1.Zhang R, Han P, Yang H, Ouyang K.F, Lee D, Lin Y.F, Ocorr K, Kang G, Chen J, Stainier Y.R.D, Yelon D, and Chi N.C. (2013) In vivo cardiac reprogramming contributes to zebrafish heart regeneration.Nature. 498: 497-501.
2.Zhang R, Yang J, Zhu J, and Xu X. (2009) Depletion of Tcap leads to muscular dystrophy in zebrafish embryos due to disruption of sarcomere-membrane interaction, not of sarcomere assembly. Human Molecular Genetics. 18: 4130-4140.
3.Zhang R, and Xu X. (2009) Transient and transgenic analysis of the zebrafish ventricular myosin heavy chain (vmhc) promoter: an inhibitory mechanism of ventricle-specific gene expression. Developmental Dynamics. 238:1564-1573.
4.Dickover M, Zhang R, Han P, and Chi N.C. (2013) Zebrafish cardiac injury and regeneration models: a non-invasive and invasive in vivo model of cardiac regeneration. Methods in Molecular Biology. 1037: 463-73.
5.Huang W, Zhang R, and Xu X. (2009) Myofibrillogenesis in the developing zebrafish heart: a functional study of tnnt2. Developmental Biology. 331: 237-249.
6.Sun X, Zhang R, Lin X, and Xu X. (2008) Wnt3a regulates the development of cardiac neural crest cells by modulating expression of cysteine-rich intestinal protein 2 in rhombomere 6. Circulation Research. 102:831-839.