领域：生物产业 学校：复旦大学职称：研究员
长期从事代谢相关疾病的分子机制的研究。运用生物化学、细胞生物学、蛋白组学等研究手段，在细胞和小鼠整体水平探索代谢通路的调控对肿瘤、糖尿病和心衰等衰老疾病的影响，揭示了去乙酰化酶sirtuins家族是调控衰老相关疾病的一条重要的通路。 现主持国家自然科学基金重大研究计划“培育项目”和面上项目。 以第一或通讯作者共发表研究论文十余篇，包括 Cell、Molecular Cell、Nature Communications、 PNAS、JBC等，被引用超过2000 次。
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1. Wei Z#, Song J#, Wang G, Cui X, Zheng J, Tang Y, Chen X, Li J, Cui L*, Liu C*, Yu W*. Deacetylation of Serine Hydroxymethyl-transferase 2 by SIRT3 promotes Colorectal Carcinogenesis. Nature Communications 2018 9 (1), 4468
2. Cao X#, Li C#, Xiao S#, Tang Y, Huang J, Zhao S, Li X, Li J, Zhang R, and Yu W*. Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage. PNAS 2017 114 (4): 687-692
3. Yu W#, Denu RA#, Krautkramer KA, Grindle KM, Yang DT, Asimakopoulos F, Hematti P, Denu JM*. Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies. J. Bio. Chem. 2016 Feb 12; 291(7): 3268-79 (# equal contribution)
4. Peek CB, Affinati AH, Ramsey KM, Kuo HY, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C, Levine DC, Bacsik DJ, Gius D, Newgard CB, Goetzman E, Chandel NS, Denu JM, Mrksich M, Bass J.* Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice. Science. 2013 342 (6158), 1243417
5. Yu W#, Dittenhafer-Reed KE, Denu JM*. SIRT3 deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status. J. Bio. Chem. 2012 Apr 20; 287 (17), 14078-14086. (Best of 2012 paper)
6. Hallows WC#, Yu W#, Smith BC, Devries MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan KL, Denu JM*. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Molecular Cell. 2011 Jan 21; 41(2):139-49. (# equal contribution)
7. Someya S#, Yu W#, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM*, Prolla TA*. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell. 2010 Nov 24; 143(5):802-12. (# equal contribution)
8. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Yang P, Li H, Li Y, Shi J, Qin l, Lei Q, Xiong Y, Guan KL. Regulation of cellular metabolism by protein lysine acetylation. Science. 2010 327.5968,1000-1004.
9. Yu W#, Lin Y, Yao J, Huang W, Lei Q, Xiong Y, Zhao S, Guan KL. Lysine 88 Acetylation Negatively Regulates Ornithine Carbamoyltransferase Activity in Response to Nutrient Signals. J. Bio. Chem. 2009 284(20): 13669-1367
