领域：生物产业 学校：复旦大学职称：教授
利用生物化学、药物化学、分子药理学等手段，进行疾病发生的分子机制研究及相关药物的
研发。重点研究：① IDO（吲哚胺-2,3双加氧酶）催化的色氨酸代谢通路失调与疾病的关系，
筛选发现干预IDO及相应的信号传导的抑制剂；② Drug Transporter (药物转运蛋白) 在药物
代谢中的功能及其表达、定位的调控机制研究。
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1. 杨青等。一种N-苄基色胺酮衍生物及其制备方法和应用（PCT专利）。 2018、2019年已获得中国、美国、欧洲、日本、澳洲、南非、香港等国家和地区授权。
2. Dan Yang, Shengnan Zhang, Xin Fang, Leilei Guo, Nan Hu, Zhanling Guo, Xishuai Li, Shuangshuang Yang, Jin Chao He, Chunxiang Kuang* and Qing Yang* N-benzyl/aryl substituted Tryptanthrin as Dual Inhibitors of Indoleamine 2, 3-Dioxygenase and Tryptophan 2, 3-dioxygenase. Journal of Medicinal Chemistry 2019, 62 (20), 9161-9174.
3. Dan Yang, Tianqi Li, Yinlong Li, Shengnan Zhang, Weirui Li, Heng Liang, Zikang Xing, Lisha Du, Jinchao He, Chunxiang Kuang, Qing Yang*, H2S suppresses indoleamine 2, 3-dioxygenase 1 and exhibits immunotherapeutic efficacy in murine hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research, 2019, 38:88.
4. Heng Liang, Mantian Chen, Fangfei Qi, Lei Shi, Zhenzhen Duan, Ruoyu Yang, Jinchao He, Bin Lou, Yigang Li*, Qing Yang*.The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis. Signal Transduction and Targeted Therapy, 2019 4:23.
5. Lisha Du, Zikang Xing, Bangbao Tao, Tianqi Li, Dan Yang, Weirui Li, Yuanting Zheng, Chunxiang Kuang, Qing Yang*. Both IDO1 and TDO contribute to the malignancy of gliomas via Kyn-AhR-AQP4 signal pathway. Signal Transduction and Targeted Therapy. 2019 Accepted
6 Shengnan Zhang, Fangfei Qi, Xin Fang, Dan Yang, Hairong Hu, Qiang Huang, Chunxiang Kuang, Qing Yang*, Tryptophan 2,3-dioxygenase Inhibitory Activities of Tryptanthrin Derivatives. Eur J Med Chem. 2018, 160, 133-145.
7.Yang Li, Nan Hu, Dan Yang, Gregory Oxenkrug, Qing Yang*, Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism, FEBS J., 2017, 284, 948-966.
8.Juanjuan Li, Yang Li, Dan Yang, Nan Hu, Zhanling Guo, Chunxiang Kuang and Qing Yang*, Establishment of a human indoleamine 2, 3-dioxygenase2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. Eur J Med Chem. 2016, 123:171-179.
9. Guiying Jin#, Yang Li#, Yuwen Zhu, Lisha Du, Junkai Yan and Qing Yang*, SMS regulates the expression and function of P-gp and MRP2 in Caco-2 cells. Cell Biology and Toxicology, 2016, 32(6):483-497.
10. Yang, Shuangshuang#, Li, Xishuai#, Hu, Fangfang, Li, Yinlong, Yang, Yunyun, Yan, Junkai, Kuang, Chunxiang, Yang, Qing*, Discovery of Tryptanthrin Derivatives as Potent Inhibitors of Indoleamine 2, 3-Dioxygenase with Therapeutic Activity in LLC tumor-bearing Mice. J. Med. Chem. 2013, 56 (21), 8321–8331.
11. Zhaogang Teng, Xingang Zhu, Gengfeng Zheng, Fan Zhang, Yonghui Deng, Lichen Xiu, Wei Li, Qing Yang* and Dongyuan Zhao*, Ligand exchange triggered controlled-release targeted drug delivery system based on core–shell superparamagnetic mesoporous microspheres capped with nanoparticles. J. Mater. Chem. 2012, 22, 17677–17684.
