领域：生物产业 学校：复旦大学职称：教授
我们的基本的感觉中，嗅觉，视觉，味觉等的分子转导机制都很清楚，例如，嗅觉感觉的分子生物学转导机制的研究获得了2004年的诺贝尔奖。听觉，触觉的转导机制可以说比嗅觉的转导机制更加重要，但是其分子转导机制还是不清楚的。我们实验室把听觉，触觉作为我们研究的主要方向，力争在这个领域做出基础的，重要的，新颖的发现。据中国卫生部2012年报告，我国的新生儿的听力遗传缺陷达到千分之二左右，我国在2012年出生听力遗传缺陷儿童就有3.5万人。在进行基础科研的同时，我们也会在新生儿听力遗传缺陷的机理研究，以及其预防，诊断和治疗方向做出努力。
实验室欢迎学生，博士后和科研助理加盟。本实验室欢迎于学生博士后以及研究助理的讨论他们的职业理想和目标，并且与实验室的总体目标找到共通，帮助学生，博士后以及研究助理实现他们的职业理想和目标，实现一个共赢的，长期发展的目标。
MOLECULAR TRANSDUCION MECHANISM OF HEARING AND TOUCH
Mechanotransduction is the process by which mechanical force is transformed into neuronal signals, and is essential forhuman senses of touch, hearing and gravity rely on mechanosensation.Notwithstanding the importance of mechanosensation, its cellular and molecular mechanisms are the least well understood among the different sensory modalities. By combining Drosophila genetics, behavioral assays,electrophysiological recording and calcium imaging, we have demonstrated thatthe Drosophila NompC protein is apore-forming subunit of a mechanotransduction channel functioning in class IIIdendritic arborization (da) neurons to sense gentle touch (Yan et al, Nature, Jan 10, 2013). We will continue to use Drosophila to study hearing and touch, and will extend our our wotk to mamalin system.
...
具体了解该专家信息，请致电：027-87555799 邮箱 haizhi@uipplus.com
1. Yanyan Jia#, Yimeng Zhao#, Tsukasa Kusakizako #, Yao Wang, Chengfang Pan, Yuwei Zhang, Osamu Nureki *, Motoyuki Hattori *, Zhiqiang Yan *. TMC1 and TMC2 proteins are pore-forming subunits of mechanosensitive ion channels. Neuron, 2019.
2. Mingfeng Zhang, Dali Wang, Yunlu Kang, Jing-Xiang Wu, Fuqiang Yao, Chengfang Pan, Zhiqiang Yan*, Chen Song* & Lei Chen* (2018). Structure of the mechanosensitive OSCA channels. Nature Structural & Molecular Biology （*corresponding author)
3. Mingfeng Zhang, Xia Li, Honglan Zheng, Xiaoxu Wen, Sihan Chen, Jia Ye, Siyang Tang, Fuqiang Yao, Yuezhou Li*,Zhiqiang Yan*(2018). Brv1 Is Required for Drosophila Larvae to Sense Gentle Touch. Cell Reports, 2018 Apr 3;23(1):23-31.（*corresponding author)
4. Atsuhiro Tomita, Mingfeng Zhang, Fei Jin, Wenhui Zhuang, Hironori Takeda, Tatsuro Maruyama, Masanori Osawa, Ken-ichi Hashimoto, Hisashi Kawasaki, Koichi Ito, Naoshi Dohmae, Ryuichiro Ishitani, Ichio Shimada, Zhiqiang Yan*, Motoyuki Hattori* & Osamu Nureki* (2017). ATP-dependent modulation of MgtE in Mg2+ homeostasis. Nature Communications, 2017 Jul 27. (*corresponding author)
5. Zhiqiang Yan#, Wei Zhang#, Ye He, David Gorczyca, Yang Xiang, Li E. Cheng, Shan Meltzer, Lily Yeh Jan, and Yuh Nung Jan* (2013). Drosophila NompC is a mechanotransduction channel subunit for gentle-touch sensation. Nature, 493:221–225
6. Zhiqiang Yan, Jie Tan, Chang Qin, Yao Lu, Cheng Ding, Minmin Luo*(2008). Precise Circuitry Links Bilaterally Symmetric Olfactory Maps. Neuron,58:613–624.
7. Wei Zhang#, Zhiqiang Yan#, Bingxue Li, Lily Yeh Jan, and Yuh Nung Jan*(2014). Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae. eLife, 2014;3:e03293(#equal contribution).
