领域：生物产业 学校：复旦大学职称：教授
小鼠与人基因功能和作用机理保守，器官发育和代谢调控过程相似，对研究发育和疾病机理，发展疾病预防、诊断和治疗方法具有重要价值。本课题组建立了用于小鼠高效基因诱变和功能分析的哺乳动物piggyBac转座子、可见荧光标记和体细胞有丝分裂重组等一系列遗传学研究方法，主持培育了具有5,000多种基因突变体的世界最大小鼠基因突变体库，为进一步解析发育和疾病机理，研发疾病动物模型奠定了良好基础。目前，本课题组正依托这一小鼠突变体资源，结合细胞和生化手段筛选研究代谢和肾脏发育相关基因及作用机理。
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1. Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Ding S, Wu X*, Li G, Han M, Zhuang Y, Xu T*. Cell. 2005 Aug 12;122(3):473-83. (封面论文)
2. Ubiquitous expression of mRFP1 in transgenic mice. Zhu H, Wang G, Li G, Han M, Xu T, Zhuang Y, Wu X. Genesis. 2005 Jun;42(2):86-90.
3. Muscle atrophy in transgenic mice expressing a human TSC1 transgene. Wan M, Wu X*, Guan KL, Han M, Zhuang Y, Xu T. FEBS Lett. 2006 Oct 16;580(24):5621-7. Epub 2006 Sep 18.
4. A mitotic recombination system for mouse chromosome 17. Sun L, Wu X*, Han M, Xu T*, Zhuang Y*. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4237-41. Epub 2008 Mar 6.
5. Disruption of lysosome function promotes tumor growth and metastasis in Drosophila. Chi C, Zhu H, Han M, Zhuang Y, Wu X*, Xu T*. J Biol Chem. 2010 Jul;285(28):21817-23. Epub April 25, 2010.
6. piggyBac as a high-capacity transgenesis and gene-therapy vector in humancells and mice. Li R, Zhuang Y, Han M, Xu T, Wu X. Dis Mod Mech. 2013 May-Jun; 6(3):828-33. Epub 2013 Mar 8.
7. Histone methyltransferase ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme a20. Xia M*, Liu J*, Wu X*, Liu S, Li G, Han C, Song L, Li Z, Wang Q, Wang J, Xu T, Cao X. Immunity. 2013 Sep 19;39(3):470-81. Epub 2013 Sep 5.
