领域：生物产业 学校：复旦大学职称：教授
主要研究先天性心脏病，神经管畸形等重大出生缺陷的遗传性致病原因及其分子机制。擅长基因组结构变异，致病基因突变检测及功能分析，以及表观遗传修饰对基因表达的调控等研究；试图解析叶酸缺乏等代谢物失衡的遗传基础，及其如何影响发育信号通路导致出生缺陷发生的分子机理。
...
具体了解该专家信息，请致电：027-87555799 邮箱 haizhi@uipplus.com
1. Wang D#, Wang F#, Shi KH#, Tao H, Li Y, Zhao R, Lu H, Duan WY, Qiao, B, Zhao SM*, Wang HY*, Zhao JY* (2017). The Circulating Folate Decrease Induced by a Fidgetin Intronic Variant Is Associated with Reduced Congenital Heart Disease Susceptibility. Circulation (accepted)
2. Zhao JY#, Qiao B#, Duan WY#, Gong XH, Jiang SS, Ye ZZ, Wang J, Gu ZY, Shen HB, Shi KH, Sun SN, Huang GY*, Jin L*, Wang HY*(2013). Genetic variants reducing MTR gene expression increase risk of congenital heart disease in a Chinese population. European Heart Journal DOI: 10.1093 /eurheartj/eht221
3. Zhao JY#, Yang XY#, Shi KH#, Sun SN, Hou J, Ye ZZ, Wang J, Duan WY, Qiao Bin, Chen YJ, Shen HB, Huang GY, Jin L, Wang HY* (2013). A Functional Variant in the Cystathionine b-Synthase Gene Promoter Significantly Reduces Congenital Heart Disease Susceptibility in Han Chinese Population. Cell Research 23:242-253
4. Zhao JY, Yang XY, Gong XH, Gu ZY, Duan WY, Wang J, Ye ZZ, Shen HB, Shi KH, Hou J, Huang GY, Jin L, Qiao B*, and Wang HY* (2012). A functional variant in MTRR intron-1 significantly increases risk of congenital heart disease in Han Chinese population. Circulation 125:482-490
5. Lei YP, Zhang T, Li H, Wu BL, Jin L, Wang HY* (2010). VANGL2 Mutations Identified in Human Cranial Neural-Tube Defects. N Engl J of Med 362 (23):2232-2235
6. Wang H, Parry S, Macones G, Sammel MD, Kuivaniemi H, Tromp G, Halder I, Shriver MD, Romero R, Strauss JF (2006) A Functional SNP in the Promoter of the SERPINH1 Gene Encoding Hsp47 Increases Risk of Preterm Premature Rupture of Membranes and Preterm Birth in African-Americans. PNAS 103(36):13463-13467
7. Wang H, Parry S, Macones G, Sammel MD, Ferrand PE, Kuivaniemi H, Tromp G, Halder I, Shriver MD, Romero R, Strauss JF (2004) Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM). Hum Mol Genet 13(21):2659-2669
8. Wang HY, Zhang FC, Gao JJ, Fan JB, Liu P, Zheng ZJ, Xi H, Sun Y, Gao XC, Huang TZ, Ke ZJ, Guo GR, Feng GY, Breen G, St Clair D, He L (2000) Apolipoprotein E is a genetic risk factor for fetal iodine deficiency disorder in China. Molecular Psychiatry 5(4): 363-368
