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汪海健

领域:生物产业 学校:复旦大学职称:教授


   围绕药物与致癌物代谢酶基因变异的疾病相关功能与进化,肺癌、肝癌、肝纤维化的遗传与表观遗传机制等科学问题,从分子、细胞、临床样品、动物模型、病例对照人群、不同族群及外群等多个层面,研究疾病相关基因的生物学机制、体外体内表型、与疾病发生发展及预后的关联、族群演化与自然选择模式、及其在疾病防诊治中的转化医学意义。
 
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  1. 1、Xiang C, Wang J, Kou X, Chen X, Qin Z, Jiang Y, Sun C, Xu J, Tan W, Jin L, Lin D, He F, Wang H§. Pulmonary expression of CYP2A13 and ABCB1 is regulated by FOXA2, and their genetic interaction is associated with lung cancer. FASEB J 2015; 29(5):1986-98.
  2. 2、Jiang Y, Wang S, Zhao Y, Lin C, Zhong F, Jin L, He F§, Wang H§. Histone H3K9 demethylase JMJD1A modulates hepatic stellate cells activation and liver fibrosis by epigenetically regulating peroxisome proliferator-activated receptor γ. FASEB J 2015;29(5):1830-41.
  3. 3、Jiang Y, Wang W, Wang J, Lu Y, Chen Y, Jin L, Lin D§, He F§, Wang H§. Functional regulatory variants of MCL1 contribute to enhanced promoter activity and reduced risk of lung cancer in nonsmokers: Implications for context-dependent phenotype of an antiapoptotic and antiproliferative gene in solid tumor. Cancer 2012; 118(8):2085-95.
  4. 4、Chen X*, Wang H*, Zhou G, Zhang X, Dong X, Zhi L, Jin L, and He F§. Molecular population genetics of human CYP3A locus: signatures of positive selection and implications for evolutionary environmental medicine. Environ Health Perspect 2009; 117: 1541-8.
  5. 5、Wang H*, Ding K*, Zhang Y, Jin L, Kullo IJ§ and He F§. Comparative and Evolutionary Pharmacogenetics of ABCB1: Complex Signatures of Positive Selection on Coding and Regulatory Regions. Pharmacogenet Genomics 2007; 17: 667-678.

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