领域：生物产业 学校：复旦大学职称：研究员
以X-射线晶体学为主要手段，结合其他生物物理和生物化学方法研究生物大分子的结构和功能。主要包括：（1）RNA沉默通路中的核糖核酸酶的作用机制研究；（2）DNA复制和修复酶的结构和作用机制研究；3）具有催化功能的核酸分子的结构研究。
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具体了解该专家信息，请致电：027-87555799 邮箱 haizhi@uipplus.com
1. H. Liu, R. Wang, X. Yu, F. Shen, W. Lan, P. Haruehanroengra, Q. Yao, J. Zhang, Y. Chen, S. Li, B. Wu, L. Zheng, J. Ma, J. Lin, C. Cao*, J. Li*, J. Sheng*, J. Gan*, High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads, Nucleic Acids Res. (in press, 2018)
2. C. Yang, R. Wu, H. Liu, Y. Chen, Y. Gao, X. Chen, Y. Li, M. Ma, J. Li*, J. Gan*, Structural insights into DNA degradation by human mitochondrial nuclease MGME1, Nucleic Acids Res. doi:10.1093/nar/gky855 (2018)
3. H. Liu#, X. Yu#, Y. Chen, J. Zhang, B. Wu, L. Zheng, P. Haruehanroengra, R. Wang, S. Li, J. Lin, J. Li, J. Sheng, Z. Huang*, J. Ma*, J. Gan*, Crystal structure of an RNA-cleaving DNAzyme, Nat Commun. 8(1), doi: 10.1038/s41467-017-02203-x (2017)
4. H. Liu, F. Shen, P. Haruehanroengra, Q. Yao, Y. Cheng, Y. Chen, C. Yang, J. Zhang, B. Wu, Q. Luo, R. Cui, J. Li, J. Ma*, J. Sheng*, J. Gan*, A DNA structure containing AgI-mediated G:G and C:C base pairs, Angew Chem Int Ed Engl. 56(32):9430-9434 (2017)
5. Y. Chen, J. Zhang, H. Liu, Y. Gao, X. Li, L. Zheng, R. Cui, Q. Yao, L. Rong, J. Li, Z. Huang*, J. Ma*, J. Gan*, Unique 5’-P recognition and basis for dG:dGTP misincorporation of ASFV DNA polymerase X, PloS Biology 15(2):e1002599 (2017)
6. H. Liu#, C. Chen#, P. Haruehanroengra, Q. Yao, Y. Chen, C. Yang, Q. Luo, B. Wu, J. Li, J. Ma*, J. Sheng*, J. Gan*, Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex, Nucleic Acids Res, 45(5):2910-2918 (2017)
7. F. Shen, Z. Luo, H. Liu, R. Wang, S. Zhang, J. Gan*, J. Sheng*, Structural insights into RNA duplexes with multipile 2’-5’-linkages, Nucleic Acids Res, 45(6):3537-3546 (2017)
8. J. Zhang, H. Liu, Q. Yao, X. Yu, Y. Chen, R. Cui, B. Wu, L. Zheng, J. Zuo, Z. Huang*, J. Ma*, J. Gan*, Structural basis for single-stranded RNA recognition and cleavage by C3PO, Nucleic Acids Res, 44(19):9494-9504 (2016)
9. J. Zhao#, X. Yu#, M. Zhu, H. Kang, J. Ma, M. Wu, J. Gan*, X. Deng*, H. Liang*, Structural and molecular mechanism of CdpR involved in quorum-sensing and bacterial virulence in Pseudomonas aeruginosa, PloS Biology, 14(4):e1002449 (2016).
10. J. Gan, J. Tropea, B. Austin, D. Court, D. Waugh, X. Ji*, Structural Insight into the Mechanism of Double-Stranded RNA Processing by Ribonuclease III, Cell, 124(2), 355–366 (2006)
