领域：生物产业 学校：南京大学职称：副教授
天然药物化学化学生物学<?xml:namespace prefix="o">
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论文
| 一、王小明已经发表的部分研究成果(*通讯作者) -------------------------------------------------------------------------------- 1．Lin Hong-Yan, Li Zi-Kang, Bai Li-Fei, Baloch Karim Shahla, Wang Fang, Qiu Han-Yue, Wang Xue, Jin-Liang Qi, Rong-Wu Yang, Wang Xiao-Ming * and Yang Yong-Hua. Synthesis of phenyl thiazole acyl shikonin ester derivatives as anti-cancer agents through microtubule stabilization. Biochemical Pharmacology. 2015, 96(2), 93-106. 2．Qiu Han-Yue, Wang Peng-Fei, Li Zhen, Ma Jun-Ting, Wang Xiao-Ming, * Yang Yong-Hua, Zhu Hai-Liang. Synthesis of dihydropyrazole sulphonamide derivatives that act as anti-cancer agents through COX-2 inhibition. Pharmacological Research. 2016, 104: 86-96. 3．Qiu Han-Yue, Zhu Xiang, Luo Yue-Lin, Lin Hong-Yan, Tang Cheng-Yi, Qi Jin-Liang, Pang Yan-Jun, Yang Rong-Wu, Lu Gui-Hua, Wang Xiao-Ming,* Yang Yong-Hua. Shikonin Derivatives Targeting STAT3 SH2 Domain Induce Antitumor Effects. Scientific Reports 2017, 7, 2863. 4．Hu Yang, Li Cui-Yun, Wang Xiao-Ming, Yang Yong-Hua, Zhu Hai-Liang. 1, 3, 4-Thiadiazole: synthesis, reactions and applications in medicinal, agricultural, materials chemistry. Chemical Reviews. 2014, 114(10): 5572-5610. 5．Sun Wen-Xue, Ji Ya-Jing, Wan Yun, Han Hong-Wei, Lin Hong-Yan, Lu Gui-Hua, Qi Jin-Liang*, Wang Xiao-Ming*, Yang Yong-Hua*. Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents. Bioorganic & Medicinal Chemistry Letters 2017, 27 4066–4074. 6．Zhang Ya-Han, Han Hong-Wei, Qiu Han-Yue, Lin Hong-Yan, Yu Lu-Gang, Zhu Wan-Zhan, Qi Jin-Liang, Yang Rong-Wu, Pang Yan-Jun, Wang Xiao-Ming, * Lu Gui-Hua, and Yang Yong-Hua. Antiviral activity of a synthesized Shikonin ester against influenza A (H1N1)virus and its insights into its mechanism. Biomedicine & Pharmacotherapy 2017,93:636-645. 7．Zhang Ya-Han, Han Hong-Wei, Qiu Han-Yue, Lin Hong-Yan, Yu Lu-Gang, Zhu Wan-Zhan, Qi Jin-Liang, Yang Rong-Wu, Pang Yan-Jun, Wang Xiao-Ming, * Lu Gui-Hua, and Yang Yong-Hua. Antiviral activity of shikonin ester derivative PMM-034 against enterovirus 71 in vitro. Brazilian Journal of Medical and Biological Research 2017,50(10): e6586. 8．Qiu Han-Yue, Wang Fang, Wang Xue, Sun Wen-Xue, Qi Jin-Liang, Pang Yan-Jun, Yang Rong-Wu, Lu Gui-Hua, Wang Xiao-Ming,* Yang Yong-Hua. Design, synthesis, and biological evaluation of chalcone-containing shikonin derivatives as inhibitors of tubulin polymerization.ChemMedChem 2017,12(5):399-406. 9．Wang Zi-Zhen, Sun Wen-Xue, Wang Xue, Zhang Ya-Han, Qiu Han-Yue, Qi Jin-Liang, Pang Yan-Jun, Lu Gui-Hua, Wang Xiao-Ming,* Yu Fu-Gen, Yang Yong-Hua. Design, Synthesis, Biological evaluation and 3D-QSAR Analysis of podophyllotoxin-dioxazole combination as tubulin targeting anticancer agents. Chemical Biology & Drug Design 2017，90:236-243. 10．Qiu Han-Yue, Wang Peng-Fei, Wang Zi-Zhen, Luo Yue-Lin, Hu Dong-Qing, Qi Jin-Liang, Lu Gui-Hua, Pang Yan-Jun, Yang Rong-Wu, Zhu Hai-Liang, Wang Xiao-Ming*, Yang Yong-Hua*. Shikonin derivatives as inhibitors of tyrosyl-tRNA synthetase: Design, synthesis and biological evaluation. RSC Advances, 2016, 6, 83003-83010. 11．Han Hong-Wei, Qiu Han-Yue, Hu Cui, Sun Wen-Xue, Yang Rong-Wu, Qi Jin-Liang, Wang Xiao-Ming,* Lu Gui-Hua and Yang Yong-Hua. Design, synthesis and anti-cancer activity evaluation of podophyllotoxin-norcantharidin hybrid drugs. Bioorganic & Medicinal Chemistry Letters 2016,26(14),3237-3242. 12．Baloch Karim Shahla, Ma Lin, Wang Xue-Liang, Shi Jing, Zhu Yu, Wu Feng-Yao, Pang Yan-Jun, Lu Gui-Hua, Qi Jin-Liang, Wang Xiao-Ming,* Gu Hong-We and Yang Yong-Hua. Design, Synthesis and Mechanism of Novel Shikonin Derivatives as Potent Anticancer Agents. RSC Advances, 2015, 5(40), 31759-31767. 13．Lin Hong-Yan, Li Zi-Kang, Han Hong-Wei, Qiu Han-Yue, Gu Hong-Wei, Yang Yong-Hua, Wang Xiao-Ming.* Synthesis of novel aryl dithian valeryl podophyllotoxin ester derivatives as potential anti-tubulin agents RSC Advances, 2015, 5(59),47511-47521. 14．Lin Hong-Yan, Bai Li-Fei, Wang Fang, Wu Xun, Han Lu-Jing, Baloch Karim Shahla, Yang Yong-Hua, Wang Xiao-Ming.* Semi-synthesis and anti-lung cancer activity evaluation of aryl thiazol acyl podophyllotoxin ester derivatives. RSC Advances 2015, 5(35), 27775 - 27784. 15．Baloch Karim Shahla, Ma Lin, Xu Guo-Hua, Bai Li-Fei, Zhao Hua, Tang Cheng-Yi, Pang Yan-Jun, Yang Rong-Wu, Wang Xiao-Ming,* Lu Gui-Hua, Yang Yong-Hua. A Potent Anticancer Agent of Shikonin Derivative Targeting Tubulin, Chirality 2015, 27274-280. 16．Lin Hong-Yan, Han Hong-Wei, Bai Li-Fei, Qiu Han-Yue, Yin De-Zheng, Qi Jin-Liang, Wang Xiao-Ming,* Gu Hong-Wei and Yang Yong-Hua. Design, Synthesis and Biological Evaluation of Shikonin Thio-glycoside Derivatives: New Anti-Tubulin Agents. RSC Advances 2014,4(91)，49796-49805. 17．Qiu Han-Yue, Wang Zhong-Chang, Wang Peng-Fei, Yan Xiao-Qiang, Wang Xiao-Ming*, Yang Yong-Hua, Zhu Hai-Liang. Design, Synthesis, Evaluation and 3D-QSAR Analysis of Benzosulfonamide Benzenesulfonates as Potent and Selective Inhibitors of MMP-2. RSC Advances 2014, 4(74), 39214−39225. 18．Baloch Karim Shahla, Ling Li-Jun, Qiu Han-Yue, Ma Lin, Lin Hong-Yan, Huang Shou-Cheng, Qi Jin-Liang, Wang Xiao-Ming,* Lu Gui-Hua, Yang Yong-Hua. Synthesis and biological evaluation of novel shikonin ester derivatives as potential anti-cancer agents. RSC Advances 2014, 4(67), 35588−35596. 19．Guo Jing, Chen Xiao-Feng, Liu Jing, Lin Hong-Yan, Han Hong-Wei, Liu Hong-Chang, Huang Shou-Cheng, Baloch Karim Shahla, Andrew Kulek, Qi Jin-Liang,Wang Xiao-Ming, * Ling Li-Jun,* and Yang Yong-Hua. Novel Shikonin Derivatives Targeting Tubulin as Anti-cancer Agents. Chemical Biology & Drug Design 2014, 84(5), 603−615. 20．Wang Xiao-Ming, Lin Hong-Yan, Kong Wen-Yao, Guo Jing, Shi Jing, Huang Shou-Cheng, Qi Jin-Liang, Yang Rong-Wu, Gu Hong-Wei and Yang Yong-Hua.* Synthesis and Biological Evaluation of Heterocyclic Carboxylic Acyl Shikonin Derivatives. Chemical Biology & Drug Design 2014, 83(3):331-343. 21．Dong Jing-Jun, Li Qing-Shan, Liu Zhi-Peng, Wang Shu-Fu, Zhao Meng-Yue, Yang Yong-Hua, Wang Xiao-Ming*, Zhu Hai-Liang. Synthesis, Biological Evaluation and Molecular Docking Studies of Flavone and Isoflavone Derivatives as a Novel Class of KSP (Kinesin Spindle Protein) Inhibitors. European Journal of Medicinal Chemistry 2013, 70, 427-433. 22．Kong Wen-Yao, Chen Xiao-Feng, Shi Jing, Baloch Karim Shahla, Qi Jin-Liang, Zhu Hai-Liang, Wang Xiao-Ming* and Yang Yong-Hua. Design and Synthesis of Fluoroacylshikonin as Anticancer Agents. Chirality 2013, 25, 757-762. 23．Zhang Hao, Zheng Yu-Qiong, Guo Jing, Wang Xiao-Ming*, and Yang Yong-Hu. Synthesis, Docking and Biological Evaluations of Isoquinolonic Acid Derivatives. Chemical Research in Chinese Universities. 2013, 29(6): 1110-1114. 24．Li Yao, Zhao Chang-Po, Ma Hua-Ping, Zhao Meng-Yue, Xue Ya-Rong, Wang Xiao-Ming*, Zhu Hai-Liang. Design, Synthesis and Antimicrobial Activities Evaluation of Schiff Base Derived from Secnidazole Derivatives as Potential FabH Inhibitors. Bioorganic & Medicinal Chemistry. 2013, 21(11): 3120-3126. 25．Sun Juan, Li Ming-Hui, Qian Shao-Song, Guo Feng-Jiao, Dang Xiao-Fang, Wang Xiao-Ming*, Xue Ya-Rong, Zhu Hai-Liang. Synthesis and Antitumor Activity of 1, 3, 4-oxadiazole Possessing 1, 4-benzodioxan Moiety as a Novel Class of Potent Methionine Aminopeptidase type II Inhibitors. Bioorganic & Medicinal Chemistry Letters. 2013, 23(10): 2876-2879. 26．Lin Hong-Yan, Chen Wei, Shi Jing, Kong Wen-Yao, Qi Jin-Liang, Wang Xiao-Ming * and Yang Yong-Hua. Design, synthesis and biological evaluation of cinnamic acyl shikonin derivatives. Chemical Biology & Drug Design. 2013, 81(2), 275-283. 27．Luo Yin, Zhang Li-Rong, Hu Yang, Zhang Shuai, Fu Jie, Wang Xiao-Ming*, and Zhu Hai-Liang. Synthesis and Antimicrobial Activities of Oximes Derived from O-Benzyl hydroxylamine as FabH Inhibitors. ChemMedChem. 2012, 7(9), 1587-1593. 28．Yang Xian-Hui, Lu Xiang, Li Xi, Zhao Ting-Ting, Zhang Hui, Zhou Wen-Ping, Wang Xiao- Ming*, Gong Hai-Bin, Zhu Hai-Liang. Synthesis, biological evaluation, and molecular docking studies of 1, 3, 4-thiadiazol-2-amide derivatives as novel anticancer agents. Bioorganic & Medicinal Chemistry. 2012, 20(9): 2789-2795. 29．Qiu Ke-Ming, Wang Hai-Hong, Wang Li-Ming, Luo Yin, Yang Xian-Hui, Wang Xiao-Ming*, Zhu Hai-Liang. Design, synthesis and biological evaluation of pyrazolyl-thiazolinone derivatives as potential EGFR and HER-2 kinase inhibitors. Bioorganic & Medicinal Chemistry. 2012, 20(6): 2010-2018. 30．Zhang Hui, Lu Xiang, Zhang Li-Rong, Liu Jia-Jia, Yang Xian-Hui, Wang Xiao-Ming*, Zhu Hai-Liang. Design, synthesis and biological evaluation of N-phenylsulfonylnicotinamide derivatives as novel antitumor inhibitors. Bioorganic & Medicinal Chemistry. 2012, 20(4): 1411-1416. 31． Zhang Hong-Jia, Qin Xuan, Liu Kai, Zhu Di-Di, Wang Xiao-Ming*, Zhu Hai-Liang. Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino) phenyl-N0-phenyl-thiourea. Bioorganic & Medicinal Chemistry. 2011, 19(18): 5708-5715. 32．Sun Juan, Cao Ning, Zhang Xiao-Min, Yang Yu-Shun, Zhang Yan-Bin, Wang Xiao-Ming*, Zhu Hai-Liang. Oxadiazole derivatives containing 1, 4-benzodioxan as potential Immuno -suppressive agents against RAW264.7 cells. Bioorganic & Medicinal Chemistry. 2011, 19(16): 4895-4902. 33．Wang Xiao-Ming, Zhang Suo-Qin, Zhu Ling, Wang Si-Si, Li Xin-Yuan, Fang Qian-Rong, Yin Ya-Le, Liu Hao-Yan, Li Yao-Xian, Jia Gao-Feng, Pang Yan-Jun, Qi Jin-Liang, Wang Xiu-Qiang, Yang Yong-Hua*. Synthesis and Crystal Structure of N3-(dimethylpyrimidine) -N4-(tri-O-acetyl-xylosyl) thiourea. Chinese Journal of Structural Chemistry. 2008. 27(3): 321-325. 34．Wang Xiao-Ming, Li Yao-Xian, Liu Hao Yan, Li Xin-Yuan, Yang Yong-Hua, Jia Gao-Feng, Zhang Suo-Qin*. “Synthesis and Characterization of Novel N-glucoside”. Acta Chimica Sinica. 2008, 66(4): 492-495. 35．Wang Xiao-Ming, Zhu Tao, Zheng Liang-Yu, Li Yao-Xian, Zhang Suo-Qin, Bai Jie. “Synthesis of β-D-Glucopyranosyl Thiourea and Biological Activity”. Chinese Journal of Organic Chemistry. 2006, 26(5): 660-666. 36．Zheng Ji-Fu, Li Yao-Xian, Zhang Suo-Qin, Yang Song-Tao, Wang Xiao-Ming, Wang Yong- Zhi, Bai Jie, Liu Fu-An. New N-terminal prolyl-dipeptide derivatives as organocatalysts for direct asymmetric aldol reaction. Tetrahedron Letters. 2006, 47: 7793-7796. 37．Zheng Ji-Fu, Li Yao-Xian, Zhang Suo-Qin, Wang Xiao-Ming, Yang Song-Tao, Bai Jie, Wang Fang, Zhang Guang-Liang, Liu Fu-An. Studies on Synthesis of Novel Chiral Organocatalysts and Its Evaluations for Asymmetric Direct Aldol Reactions. Acta Chimica Sinica. 2007, 65(6): 553-556. 38．Yang Song-Tao, Zhang Suo-Qin, Zhang Guang-Liang, Wang Xiao-Ming and Li Yao-Xian. Novel Catalytic Method for Synthesis of Glycosyl Esters by Combining PTC with DMAP. Chemical Research in Chinese Universities 2007, 23(4): 426-429. 二、王小明已经发表的会议文章列表 -------------------------------------------------------------------------------- 1.Lin Hong-Yan, Li Zi-Kang, Bai Li-Fei, Baloch Karim Shahla, Wang Fang, Qiu Han-Yue, Wang Xue, Qi Jin-Liang, Yang Rong-Wu, Wang Xiao-Ming*, Yang Yong-Hua *. Synthesis of Phenyl Thiazole Acyl Shikonin Ester Derivatives as Anti-cancer Agents through Microtubule Stabilization. Drug Discovery & Therapy World Congress 2015, Boston, USA （2015. 7.22-26） 2.Han Hong-Wei, Qiu Han-Yue, Wang Xiao-Ming,* Yang Yong-Hua.* Synthesis and Biological Evaluation of Podophyllotoxin Derivatives as Potent Anticancer Agents.2015第九届有机化学会议，长春，东北师范大学（2015）（邀请报告） 3.Han Hong-Wei, Han Lu-jing, Wang Xiao-Ming*, Yang Yong-Hua*. A novel shikonin derivative induces the cervical cancer cell line Hela cells via mitochondria-mediated pathway. 2015年长三角药物化学会议，南京，中医药大学药学院（2015.11.13-14） 4.Li Deng-Chao, Shi Jing, Wang Xiao-Ming*, Yang Yong-Hua*. Synthesize and anticancer mechanism of a novel shikonin derivative as an EGFR Inhibitor. 2015年长三角药物化学会议，南京，中医药大学药学院（2015.11.13-14） 5.Qiu Han-Yue, Wang Zi-Zhen, Luo Yue-Lin, Wang Xiao-Ming*, Yang Yong-Hua*. Synthesis and evaluation of novel shikonin derivatives as potent antitumor agents. 2015年长三角药物化学会议，南京，中医药大学药学院（2015.11.13-14）（口头报告） 6.Han Hong-Wei, Han Lu-Jing, Wang Xiao-Ming,* and Yang Yong-Hua.* A novel shikonin derivative induces the cervical cancer cell line Hela cells via mitochondria-mediated pathway. 2015年长三角药物化学会议，墙报，南京，中医药大学药学院（2015.11.13-14） 7.Li Deng-Chao, Shi Jing, Wang Xiao-Ming,* and Yang Yong-Hua. * Synthesize and anticancer mechanism of a novel shikonin derivative as an EGFR Inhibitor. 2015年长三角药物化学会议，墙报，南京，中医药大学药学院（2015.11.13-14） 8.Qiu Han-Yue, Wang Zi-Zhen, Luo Yue-Lin, Wang Xiao-Ming,* Yang Yong-Hua.* Synthesis and evaluation of novel shikonin derivatives as potent antitumor agents. 2015年长三角药物化学会议，墙报，南京，中医药大学药学院（2015.11.13-14） 9.王小明,* 孔文尧, 郑雨琼, 杨永华.* 2011. 异喹啉酸衍生物的合成，中国化学会第七届有机化学学术会议论文集, No.3-8, P1195. 南京，2011.11.12-15 10.浩日沁巴图, 林红燕, 王小明,* 杨永华.* 新法合成2, 3-二氨基吡啶，中国化学会第七届有机化学学术会议论文集, No.3-3, P1190. 南京，2011.11.12-15 11.Liu Hong-Chang, Shi Jing, Wang Xiao-Ming,* Yang Yong-Hua.* synthesis of Novel 5, 8- Dihydroxy-1, 4-Naphthoquinone Derivatives, 中国化学会第七届有机化学学术会议论文集, No.3-4, P1191. 南京，2011.11.12-15 12.王小明, 刘昊琰，张靖靖，杨永华. * 邻苯二甲酰肼取代二硝基苯胺的合成，2009年，中国化学会第六届有机化学学术会议论文集; P545. 西安，2009.8.17-20 13.王小明, 李鑫源，袁文，贺斐，杨永华. * 2007 “新型Topo I异构酶抑制剂的设计与合成”.年. 中国化学会第五届有机化学学术会议论文集，P374, 郑州，2007. 8. 1-4. 14.王小明, 庞延军，刘少华，杨永华，张锁秦，李耀先. 2006. “基于生物安全新型糖酯除草化合物的设计合成” 中国农业生物技术学会生物安全分会成立会论文集，P44, 南京，2006.12.1-3. |
专著
| 石明旺主编，王小明第一副主编. 新编常用农药安全使用指南. 北京化学工业出版社（2010.12） |
专利
| 1．王小明，缪律，张浩，杨永华，浩日沁巴图，刘昊琰，杨晓亮，石明旺，田壮，郑雨琼，乙酰化糖基硫脲衍生物制备及其在异喹啉酸合成中的应用，授权号ZL201010180446.9 2．王小明，杨永华，刘洪昌，石婧，孔文尧，郭靖，黄守程，刘静，孔令如，张培培. 紫草宁苯氧羧酸酯类衍生物及其合成方法和应用.授权号ZL201210122226.X， 3．王小明，刘业好，刘根林，杨永华，刘昊琰，顾宏伟，王玲玲，朱思梅，陈静，萘茜糖类衍生物及其制备方法和应用，公开号CN 101824058A 4．王小明，杨永华，邱寒月，陆桂华，林红燕，韩洪苇. 紫草宁衍生物及其合成方法和应用，申请号201410249794.5 5．王小明，杨永华，邱寒月，林红燕，韩洪苇. 一种羟肟酸类化合物及其制备方法与应用， 公开号CN104140382A 6．王小明，杨永华，石婧. 一类新颖结构紫草宁酯作为表皮生长因子受体抑制剂的应用，申请号20130478312.9 7．杨永华, 王小明, 刘少华, 李鑫源, 刘昊琰, 赵卫国, 杨建文, 殷晶晶, 袁文勇, 圣丙刚. 紫草宁糖类衍生物及其合成方法和应用.授权号ZL200810195039.8 8．杨永华, 王小明, 浩日沁巴图, 刘洪昌, 戚金亮, 林红燕, 石婧, 孔文尧. 紫草宁含氟羧酸酯类衍生物及其合成方法和应用，公开号CN102491897A 9．杨永华，王小明，浩日沁巴图，韩秋敏，刘洪昌，林红燕，石婧，孔文尧. 二取代和三取代糖基紫草宁衍生物及其制备方法和应用，公开号CN102516330A 10．杨永华，王小明，林红燕，石婧，刘洪昌，孔文尧，浩日沁巴图，黄守程，紫草宁肉桂酸酯类衍生物及其合成方法和应用，公开号CN102531893A 11．杨永华，孔文尧，石婧，王小明，张培培，刘洪昌，林红燕，孔令如，刘静，郭靖. 一类紫草宁酯类衍生物的合成方法及应用，公开号CN102659661A 12．杨永华，夏红梅，戚金亮，王小明，杨荣武，刘洪昌，浩日沁巴图，张靖靖，孔文 尧.紫草宁及其衍生物或修饰物的脂质体的制备方法和应用， 公开号CN102091037A |
