领域：生物产业 学校：南京大学职称：副教授
从事哺乳动物代谢性疾病的研究，尤其是肥胖导致的Ⅱ型糖尿病和心血管疾病。主要是从转录和转录后加工水平对线粒体的功能进行研究，从线粒体的生理功能到病理转变的全新角度，解释多种代谢性疾病潜在的分子生物学机制与联系。对各种代谢性疾病，尤其是肥胖引起的代谢综合症，从回复线粒体功能，恢复机体能量平衡的角度寻找新的更有效治疗途径和药物靶点。
1）肥胖与2型糖尿病的分子机制
2）心血管疾病的分子机制与治疗
3）肿瘤恶病质对机体代谢的影响及治疗
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具体了解该专家信息，请致电：027-87555799 邮箱 haizhi@uipplus.com
代表性论文
1.The potential atheroprotectiverole of plant MIR156a as a repressor of monocyte recruitment on inflamed human endothelial cells. J NutrBiochem. (2018) Jul; 57: 197-205. HouD, He F, Ma L, Cao M, Zhou Z, Wei Z, XueY, Sang X, Chong H, TianC, ZhengS, Li J, Zen K, Chen X, Hong Z, Zhang CY, Jiang X.2.The Jun/miR-22/HuRregulatory axis contributes to tumorigenesisin colorectal cancer. MolCancer. (2018) Jan 19; 17(1):11. Liu Y, Chen X, Cheng R, Yang F, Yu M, Wang C, Cui S, Hong Y, Liang H, Liu M, Zhao C, Ding M, Sun W, Liu Z, Sun F, Zhang C, Zhou Z, Jiang, X, Chen X. 3.Characterization of serum miRNAsas molecular biomarkers for acute Stanford type A aortic dissection diagnosis. SciRep. (2017) Oct 20; 7(1):13659. XuZ, Wang Q, Pan J, Sheng X, HouD, Chong H, Wei Z, ZhengS, XueY, Zhou Q, Cao H, Zhang CY, Wang D, Jiang X.4.Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16. Nature Communications. (2016)May 31; 7:11533. Ding H, ZhengS, Garcia-Ruiz D, HouD, Wei Z, Liao Z, Li L, Zhang Y, Han X, Zen K, Zhang CY, Li J, Jiang X. 5.MicroRNA-19b/221/222 induces endothelial cell dysfunction via suppression of PGC-1α in the progression of atherosclerosis. Atherosclerosis.(2015)Aug; 241(2):671-81. XueY, Wei Z, Ding H, Wang Q, Zhou Z, ZhengS, Zhang Y, HouD, Liu Y, Zen K, Zhang CY, Li J, Wang D, Jiang X6.Small non-coding RNAs transfer through mammalian placenta and directly regulate fetal gene expression. Protein Cell. (2015) Jun;6(6):391-6.Li J, Zhang Y, Li D, Liu Y, Chu D, Jiang X, HouD, Zen K, Zhang CY 7.Norathyriolreverses obesity- and high-fat-diet-induced insulin resistance through inhibition of PTP1B. Diabetologia. (2014) Oct; 57(10):2145-54.Ding H, Zhang Y, XuC, HouD, Li J, Zhang Y, PengW, Zen K, Zhang CY, Jiang X.8.MicroRNA-495 induces breast cancer cell migration by targeting JAM-A. Protein Cell. (2014) Cao M, NieW, Li J, Zhang Y, Yan X, Guan X, Chen X, Zen K, Zhang CY, Jiang X, HouD 9.Directing RNaseP-mediated cleavage of target mRNAs by engineered external guide sequences in cultured cells. Methods MolBiol. (2014) 1103:45-56. Jiang X, SunkaraN, Lu S, Liu F. （专著）10.Sustained high protein-tyrosine phosphatase 1B activity in the sperm of obese males impairs the sperm acrosome reaction. J BiolChem. (2014) Mar 21; 289(12):8432-41. Shi L, Zhang Q, XuB, Jiang X, Dai Y, Zhang CY, Zen K11.miR-150 promotes the proliferation and migration of lung cancer cells by targeting SRC kinase signallinginhibitor 1. EurJ Cancer. (2014) Mar; 50(5):1013-24. Cao M, HouD, Liang H, Gong F, Wang Y, Yan X, Jiang X, Wang C, Zhang J, Zen K, Zhang CY, Chen X.12.The smallest capsid protein mediates binding of the essential tegument protein pp150 to stabilize DNA-containing capsids in human cytomegalovirus. PLoSPathog. (2013) Aug; 9(8):e 1003525. Dai X, Yu X, Gong H, Jiang X, AbenesG, Liu H, ShivakotiS, Britt WJ, Zhu H, Liu F, Zhou ZH.13.Microvesicle-mediated transfer of microRNA-150 from monocytes to endothelial cells promotes angiogenesis. J BiolChem. (2013) Aug 9; 288(32):23586-96. Li J, Zhang Y, Liu Y, Dai X, Li W, CaiX, Yin Y, Wang Q, XueY, Wang C, Li D, HouD, Jiang X, Zhang J, Zen K, Chen X, Zhang CY.14.Effective inhibition of cytomegalovirus infection by external guide sequences in mice. ProcNatlAcadSciUSA. (2012) Aug 7; 109 (32):13070-5. Jiang X, Gong H, Chen YC, Vu GP, TrangP, Zhang CY, Lu S, Liu F. 15.RibonucleaseP-mediated inhibition of human cytomegalovirus gene expression and replication induced by engineered external guide sequences. RNA Biol. (2012) Sep 9 (9):1186-95. Jiang X,Chen YC, Gong H, TrangP, Lu S, Liu F.
