领域：生物产业 学校：南京大学职称：教授
主要进行炎症相关免疫微环境调控的研究，以巨噬细胞功能重编程为切入点，研究组织微环境的炎性调控及相关信号转导机制，同时研发细胞免疫治疗相关新技术。入选教育部新世纪优秀人才计划；自然科学基金委创新研究团队骨干之一。主持多项国家、省、部级科研项目；
获得多项科研、教学奖励，获教育部优秀博士生导师提名奖及江苏省优秀博士生导师；在国际一流刊物发表多篇学术论文，并有多项已授权专利技术。研究方向： 分子免疫学，主要课题内容如下：1. 炎症及肿瘤微环境免疫调控2. 干细胞分化及细胞免疫治疗
Our research interests are focused on the functional regulation of tissue resident macrophages in inflammatory microenvironment. We are trying to investigate the exact roles of certain macrophage subsets in the development and prognosis of inflammation-associated diseases such as cancer and autoimmune inflammation. A major focus of our group has been to determine the new functional features of macrophages in tumor microenvironmen/liver tissue and to explore the underlying mechanisms. In collaboration with Nanjing Gulou Hospital, we have been developing the platform for modifying the molecule structure of macrophages for future clinical application, as well as building up the MSC (Mesenchymal Stem Cell) therapeutic strategy in autoimmune inflammation treatment.
3. 临床诊断技术
We are collaborating with clinical colleagues to develop the novel technologies for analyzing genes and molecules which are associated with human diseases, particularly cancer. We have established a new, sensitive approach for nucleic acid detection, which is to be used to detect DNA or RNA with no need for amplification, hereby, revealing the actual number of live viruses. We are also working on antigen modification and antibody production. Currently, we have been trying to apply the novel materials to the test system for improving the detection properties of clinical diagnosis.
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具体了解该专家信息，请致电：027-87555799 邮箱 haizhi@uipplus.com
论文
Selected publications:
Niu Z.Y., Shi Q., Zhang W.L., Chen B., Wang Q.S., Zhao X.Y., Chen J.J., Shu Y.X., Cheng N., Feng X.J., Ji J.G., Shen P.P.*, Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs. Nature Communications, 2017, 8(1):766,
Su Y.Y., Hu M., Fan C.H., He Y., Li Q.N., Li W.X., Wang L.H., Shen P.P.*, Huang Q.*, The cytotoxicity of CdTe quantum dots and the relative contributions from released cadmium ions and nanoparticle properties.Biomaterials, 2010,31:p. 4829-4834.
Su Y.Y., He Y., Lu H.T., Sai L., Li Q.N., Li W.X., Wang L.H., Shen P.P.*, Huang Q., Fan C.H. *,The cytotoxicity of cadmium based, aqueous phase Synthesized, quantum dots and its modulation by surface coatin. Biomaterials, 2009, 30:p. 19-25.
Liu P., Li C., Zhang R.X., Tang Q., Wei J., Lu Y., Shen P.P. *, An ultrasensitive electrochemical immunosensor for procalcitonin detection based on the gold nanoparticles-enhanced tyramide signal amplification strategy. Biosensors and Bioelectronics,2019,126:p.543-550.
Lin X.Z., Zheng W., Liu J., Zhang Y.,Qin H.H., Wu H.C., Xue B., Lu Y., Shen P.P. *, Oxidative stress in malignant melanoma enhances TNF-α secretion of tumor-associated macrophages that promote cancer cell invasion. Antioxidants & Redox Signaling,2013, 19(12):p.1337-1355.
Lu Y., Zhang Y., Li L., Feng X.J., Ding S., Zheng W., Li J.X.,Shen P.P.*, TAB1: a target of triptolide in macrophages. Chemistry & Biology,2014, 21(2):p.246-256.
Xu H.W., Wei Y.N., Zhang Y., Xu Y.C., Li F., Liu J., Zhang W., Han X.D., Tan R.X.,Shen P.P.*, Oestrogen attenuates tumor malignancy in hepatocellular carcinoma progression. Journal of Pathology,2012, 228: p.216–229.
FengX.J., Weng D., Zhou F.F., Young D. Owen, Qin H.H., Zhao J.F., Yu W., Huang Y.H., Chen J.J., Fu H.J., Yang N.F., Chen D.H., Li J.X., Tan R.X., Shen P.P.* , Activation of PPARγ by a natural flavonoid modulator, apigenin ameliorates obesity-related inflammation via regulation of macrophage polarization. EbioMedicine, 2016, 9: p.61–76.
Dai H.R., Zhang W.Y., Li X.L., Han Q.W., Guo Y.L., Zhang Y.J., Wang Y., Wang C.M., Shi F.X., Zhang Y., Chen M.X., Feng K.C., Wang Q.S., Zhu H.L., Fu X.B., Li S.X., Han W.D.*, Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia. Oncoimmunology,2015, 4(11):e1027469.
Sun T.Z., Li X.D., Shen P.P.*, Modeling amplified p53 responses under DNA-PK inhibition in DNA damage response. Oncotarget, 2017, 8(10):p.17105-17114.
Shu Y.X., Lu Y., Pang X.J., Zheng W., Huang Y.H., Li J.H., Ji J.G., Zhang C., Shen P.P.*, Phosphorylation of PPARγ at Ser84 promotes glycolysis and cell proliferation in hepatocellular carcinoma by targeting PFKFB4. Oncotarget, 2016, 7(47):p.76984-76994.
Feng X.J., Yu W., Li X.D., Zhou F.F., Zhang W.L., Shen Q., Li J.X., Zhang C., Shen P.P.*, Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. Biochemical Pharmacology, 2017, 136: p. 136-149.
Ding S., Qian Steven Y., Zhang Y., Wu W.L., Lu G.S., Lu Y., Feng X.J., Li L., Shen P.P.* Establishment of immunoassay for detecting HPV16 E6 and E7 RNA.Scientific Reports, 2015, 5:p. 13686.
Feng X.J., Sun T.Z., Bei Y.C., Zheng W., Lu Y., Shen P.P.*, S-nitrosylation of ERK inhibits ERK phosphorylation and induces apoptosis.Scientific Reports,2013, 3:p. 1814.
Niu Z.Y., Tang J.J., Zhang W.L., Chen Y.J., Huang Y.H., Chen B., Li J.H., Shen P.P.*, Caspase-1 promotes monocyte/macrophage differentiation by repressing PPARγ. FEBS Journal, 2017, 284:p. 568–585.
Pang X.J., Wei Y.N., Zhang Y., Zhang M.Y., Lu Y.*, Shen P.P.*,PPARγ activation inhibits hepatocellular carcinoma cell invasion by up-regulating PAI-1. CancerScience, 2013, 104(6):p. 672-680.
Yao Y.F.,Shi Q., Chen B.,Wang Q.S.,Li X.D.,Li L.,Huang Y.H.,Ji J.G., Shen P.P.*,IdentificationofCaspase-6asaNewRegulatorofAlternativelyActivated Macrophages. Journal of Biological Chemistry, 2016, 291(33):p. 17450-17466.
Yang W.W., Lu Y., Xu Y.C., Xu L.Z., Zheng W., Wu Y.Y., Li L., Shen P.P.*, Estrogen represses Hepatocellular Carcinoma (HCC) growth via inhibiting alternative activation of tumor-associated macrophages. Journal of Biological Chemistry,2012, 287(48):p. 40140-40149.
Dai H.R., Zhou Y., Tong C., Guo Y.L., Shi F.X., Wang Y., Shen P.P.*, Restoration of CD3+CD56+cell level improves skin lesions in severe psoriasis: A pilot clinical study of adoptive immunotherapy for patients with psoriasis using autologous cytokine-induced killer cells. Cytotherapy, 2018, 20:p. 1155-1163.
已授权与申请专利
沈萍萍，丰秀静，徐加发，杨威威，一种白杨素噻唑衍生物及其制备方法和应用。2015.08.05，中国，ZL 201310169151.5
沈萍萍，丁森，卢彦，一种基于酶联免疫分析的HPV核酸检测试剂盒及其应用。2016.02.23，中国，ZL 201410298037.7
沈萍萍，蔡梅红，一种杂合肽囊素佐剂及其制备方法和应用。2014.12.10，中国，ZL 201210295586.X
沈萍萍，蔡梅红，一种重组β干扰素的制备方法及其应用。2013.03.13，中国，ZL 201110044022.4
沈萍萍，卢彦，徐加法，香豆素标记雷公藤内酯醇及其制备方法和应用。2012.07.25，中国，ZL 200910035979.5
华子春，沈萍萍，潘晓，一种小分子化合物的酵母三杂交检测系统及其在藻毒素检测中的应用。2010.12.01，中国，ZL 200710132796.6
沈萍萍，刘培，张瑞旋，一种抗原特异性B细胞筛选方法及其在单克隆抗体制备中的应用，2018.03.06，申请号201810180889.4
沈萍萍，章文龙，唐嘉荩，黄亚红，一种高效的小鼠骨髓来源巨噬细胞的转染方法及其应用，2018.10.17，申请号201811233196.3
沈萍萍，贝云成，黄亚红，一种抑制CDK5协同免疫治疗在抑制乳腺癌中的应用。2018.03.06，申请号201810180887.5
沈萍萍，贝云成，刘培，一种用于乳腺癌免疫治疗的联合用药物组合及其应用。2018.05.14，申请号201810453420.3
沈萍萍，姚永芳，陈兵，黄亚红，一种间充质干细胞在制备治疗M5型白血病药物中的应用。2016.04 .06，申请号201610208206.2
沈萍萍，牛志远，一种具有抗肿瘤功能的免疫细胞及其应用。2016.12.02，申请号201611095758.3
沈萍萍，丁森，黄亚红，刘培，一种非扩增型核酸杂交捕获体系及其在核酸检测中的应用。2016.07.20，申请号201610477993.0
1.参编“植物成分分析”，科学出版社，2003年获选国家教育部优秀研究生教材
2.参编“生物化学原理”，高等教育出版社出版， 高等教育“十二五国家级规划教材
