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刘忠华

领域:生物产业 学校:东北农业大学职称:教授

1.猪早期胚胎发育调控:转录因子与非编码RNA在胚胎内细胞团和滋养层细胞分化中的功能解析; 2.猪多能性干细胞系建立及多能性调控机制:探索猪多能性细胞建系影响因素,建立猪多能性干细胞培养体系,解析猪多能性调控分子机制; 3.猪体细胞重编程机制:体细胞核移植和诱导多潜能干细胞建立过程中体细胞核发生重编程中的现象与表观调控机制; 4.猪基因工程:通过基因编辑技术体系创制人类疾病模型猪,培育具有育种价值的畜牧用猪;...

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教育背景

1990.09-1994.06:东北农大畜牧系,学士 1994.09-1997.06:东北农大繁殖学专业,硕士研究生 1997.09-2000.06:东北农大组织胚胎专业,博士研究生 2000.07-2002.06:中国科学院动物学研究所,代培博士后 2002.08-2004.08:美国密苏里大学动物科学研究中心,博士后 2006.11-2007.05:日本熊本大学医学部动物资源与支援中心,访问教授 2008.01-2008.04:日本熊本大学医学部动物资源与支援中心,访问教授 2012.12-2013.ᠦ୔

工作经历

1997.07-1999.07:东北农大动科院,助教; 1999.08-2004.08:东北农大动科院,讲师; 2004.08-2006.09:东北农大生命学院,副教授; 2006.09-至今:东北农大生命学院,教授,博导。

项目课题经历

论文、成果、著作等

1.Yanjun Huan, Jiang Zhu, Bo Huang, Qinran Kong, Zhonghua Liu.Trichostatin A rescues the disrupted imprinting induced by somatic cell nuclear transfer in pigs.2015 PlosOne May 11;10(5):e0126607. doi: 10.1371/journal.pone.0126607 2.Wang Jiaqiang, Li Xin, Zhao Yanhua, Li Jingyu, Zhou Qi, Liu Zhonghua. Generation of Cell-type-specific Gene Mutations by Expressing the sgRNA of the CRISPR System from the RNA Polymerase II Promoters. Protein & cell 2015 Sep;6(9):689-92. doi: 10.1007/s13238-015-0169-x 3.Yu Zhang, Jing Ma, Jiawei Lv, Renyue Wei, Yimei Cong, Hai Li,Zhonghua Liu Endothelial cell regulate cardiac myocyte reorgnisation through B1-intergrin signalling. 2015 Cell Phisiol Biochem. 35(5):1808-20 4.Shichao Liu; Gerelchimeg Bou; Ruizhen Sun; Shimeng Guo; Binghua Xue; Renyue Wei; Austin J Cooney; Zhonghua LiuSOX2 is the faithful marker for pluripotency in pig:Evidence from embryonic studies. Developmental Dynamics 2015 Vol 244:619-627 5.Jianyu Wang, Renyue Wei, Gerelchimeg Bou, Zhonghua Liu. Tbx3 and Nr5α2 can improve the viability of porcine induced pluripotent stem cells (piPSCs) after dissociation into single cells through inhibiting RHO-ROCK-MLC signaling. Biochemical and Biophysical Research Communications(BBRC) 2015 Vol 456:743-49 6.Qingran Kong, Tang Hai, Jing Ma, Tianqing Huang, Dandan Jiang, Bingteng Xie, Meiling Wu,Jiaqiang Wang, Yuran Song, Ying Wang, Yilong He, Jialu Sun, Kui Hu, Runfa Guo, Liu Wang,Qi Zhou, Yanshuang Mu, Zhonghua Liu1. Rosa26 locus supports tissue-specific promoter driving transgene expression specifically in Pig. PLOS ONE 2014 Vol 9, Issue 9, e107945 7.Li JY,Huan YJ, Xie BT,Wang JQ, Zhao YH,Jiao MX,Huang TQ,Kong QR,andLiu ZH. Identification and characterization of an oocyte factor required for sperm decondensation in pig. Reproduction 2014 Oct;148(4):367-75 8.Kong Q, Ji G, Xie B, Li J, Mao J, Wang J, Liu S, Liu L, Liu Z. Telomere Elongation Facilitated by Trichostatin A in Cloned Embryos and Pigs by Somatic Cell Nuclear Transfer. Stem Cell Rev. Rep. 2014 Jun;10(3):399-407 9.Kong Q, Xie B, Li J, Huan Y, Huang T, Wei R, Lv J, Liu S, Liu Z. Identification and Characterization of an Oocyte Factor Required for Porcine Nuclear Reprogramming. J Biol Chem. 2014 Mar 7;289(10):6960-8 Wang JY, Gu Q, Hao J, Jia YD, Xue BH, Jin HH, Ma J, Wei RY, Hai T, Kong QR, Bou G, Xia P, Zhou Q, Wang L, Liu ZH. Tbx3 and Nr5α2 Play Important Roles in Pig Pluripotent Stem Cells. Stem Cell Rev and Rep. 2013 Oct;9(5):700-8

专利、著作版权等

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