1993.9-1997.7 生物技术专业 东北农业大学 学士 1997.9-2000.7 预防兽医学专业 东北农业大学 硕士 2002.9-2005.7 预防兽医学专业 东北农业大学 博士

2000.7-2003.8 东北农业大学生命科学学院 助教 2003.8-2005.8 东北农业大学生命科学学院 讲师 2005.8-至今 东北农业大学生命科学学院 副教授 2005.10-2009.7 黑龙江省农科院 博士后 2007.10-至今 东北农业大学生命科学学院制药工程系 系主任 2011.3-2012.3 美国乔治亚大学 访问学者

1.Ming Zhou, Guoqing Zhang, Guiping Ren, Clement W. Gnanadurai, Zhenguang Li, Qingqing Chai, Yang Yang, Christina M. Leyson, Wenxue Wu, Min Cui, Zhen F. Fu. Recombinant rabies viruses expressing GM-CSF or flagellin are effective vaccines for both intramuscular and oral immunizations. PLOS One. 2013; 8(5): e63384. (Factor：3.73) 2.Fangming Kan, Guiping Ren, Mo Guo, Jianying Qi, Yu Zhang, Yang Han, Yakun Zhang, Deshan Li. Construction of an anti-IL-1β scfv and TNFRI fusion protein and its therapeutic effect on RA mice model. Current Pharmaceutical Biotechnology, 2013, 14（12）：1048-1061 （Factor：2.69） 3.Ye X, Qi J, Sun G, Ren G, Zhu S, Wu Y, Yu D, Zhao J, Liu M, Li D. Enhancement of the pharmacological efficacy of FGF-21 by genetic modification and PEGylation. Curr Pharm Biotechnol. 2013;14(15):1287-1298. （Factor：2.69） 4.Shenglong Zhu, Lei Ma, Yunzhou Wu, Xianlong Ye, Tianyuan Zhang, Qingyang Zhang, Lubna Muhi Rasoul,Yunye Liu,Mo Guo, Bing Zhou, Guiping Ren, and Deshan Li. FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway. Acta Biochim Biophys Sin. 2014; 46(12):1041-1048. （Factor：2.089） 5.Xianlong Ye, Jianying Qi, Guiping Ren, Pengfei Xu, Yunzhou Wu, Shenglong Zhu, Dan Yu, Shujie Li, Qiang Wu, Rasool Lubna Muhi, Deshan Li. Long-lasting anti-diabetic efficacy of PEGylated FGF-21 and liraglutide in treatment of type 2 diabetic mice. Endocrine, 2015,49（3）：683–692 ( Impact Factor: 3.527) 6.Yinhang Yu, Siming Li, Yaonan Liu, Guiyou Tian, Qingyan Yuan, Fuliang Bai, Wenfei Wang, Zhiyi Zhang, Guiping Ren, Yu Zhang, Deshan Li. Fibroblast growth factor 21 (FGF21) ameliorates collagen-induced arthritis through modulating oxidative stress and suppressing nuclear factor-kappa B pathway. International Immunopharmacology. 2015,25(1):74-82 ( Impact Factor: 2.711) 7.Yinhang Yu,  Fuliang Bai,  Yaonan Liu,  Yongbi Yang,  Qingyan Yuan,  Dehua Zou,  Susu Qu,  Guiyou Tian,  Liying Song,  Tong Zhang,  Siming Li,  YunYe Liu,  Wenfei Wang,  Guiping Ren,  Deshan Li. Fibroblast growth factor (FGF21) protects mouse liver against D-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways. Mol Cell Biochem. 2015, 403(1-2):287-299 ( Impact Factor: 2.388) 8.Pengfei Xu, Xianlong Ye, Yingjie Zhang, Qingyan Yuan, Mingyao Liu, Qiang Wu, Guiping Ren, Deshan Li. Long-acting hypoglycemic effects of PEGylated FGF21 and insulin glargine in mice with type 1 diabetes. Journal of Diabetes and its Complications. 2015,29(1):5-12 （Factor：3.005） 9.Yinhang Yu, Fuliang Bai, Wenfei Wang, Yaonan Liu, Qingyan Yuan, Susu Qu, Tong Zhang, Guiyou Tian, Siming Li, Deshan Li, Guiping Ren. Fibroblast growth factor 21 protects mouse brain against D-galactose induced aging via suppression of oxidative stress response and advanced glycation end products formation. Pharmacology, Biochemistry and Behavior, 2015, 133:122-13 ( Impact Factor: 2.82) 10.Pengfei Xu,  Yingjie Zhang,  Wenfei Wang,  Qingyan Yuan,  Zhihang Liu,  Lubna Muhi Rasoul,  Qiang Wu,  Mingyao Liu,  Xianlong Ye,  Deshan Li,  Guiping Ren. Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice. Digestive Diseases and Sciences, 2015, 60（10）:3032-3043 ( Impact Factor: 2.613) 11.Yin Bai, Yanmin Chen, Nan Zhang, Xiaochen Guo, Jingzhuang Zhao, Fuxiang Wang, Pengfei Xu, Qingyan Yuan, Jianying Qi, Wenfei Wang, Deshan Li and Guiping Ren. Isolation of the neutralization ScFvs against HBV infection from the immunized population. Current Pharmaceutical Biotechnology, 2015, 16(10): 902-910. ( Impact Factor: 1.95) 12.Guiping Ren, Guiyou Tian, Yunye Liu, Jinjiao He, Xinyu Gao, Yinhang Yu, Xin Liu, Xu Zhang, Tian Sun, Shuangqing Liu, Jiechao Yin, and Deshan Li. Recombinant Newcastle Disease Virus Encoding IL-12 and/or IL-2 as Potential Candidate for Hepatoma Carcinoma Therapy. Technology in Cancer Research & Treatment ( Impact Factor: 1.730) 13.Qi J, Kan F, Ye X, Guo M, Zhang Y, Ren G, Li D. A bispecific antibody against IL-1β and IL-17A is beneficial for experimental rheumatoid arthritis. Int Immunopharmacol. (International Immunopharmacology). 2012, 14(4):770-778. ( Impact Factor:2.376) 14.Chen Z, Zhou M, Gao X, Zhang G, Ren G, Gnanadurai CW, Fu ZF, He B. A novel rabies vaccine based on a recombinant parainfluenza virus 5 expressing rabies virus glycoprotein. J Virol. 2013, 87(6):2986-2993. (factor：5.076) 15.Zhang Y, Ren G, Guo M, Ye X, Zhao J, Xu L, Qi J, Kan F, Liu M, Li D. Synergistic effects of interleukin-1β and interleukin-17A antibodies on collagen-induced arthritis mouse model. Int Immunopharmacol. (International Immunopharmacology.) 2013, 15(2):199-205. ( Impact Factor:2.376) 16.Jianying Qi, Xianlong Ye, Guiping Ren, Fangming Kan, Yu Zhang, Mo Guo, Zhiyi Zhang, Deshan Li. Pharmacological efficacy of anti-IL-1β scFv, Fab and full-length antibodies in treatment of rheumatoid arthritis. Molecular Immunology. 2013, 57, (2): 59–65 (factor：2.645) 17.Tianhe Li, Liming Xu, Guiping Ren, Chengkai Yin, Bing Zhou, Xianlong Ye, Qingcui Li, Ning Li and Deshan Li. A Neutralization scFv Antibody against IL-1β Isolated from a NIPA-based Bacterial Display Library. Current Pharmaceutical Biotechnology. 2013, 14(6):571-581 (factor：2.69) 18.Zheng Lv, Tian-Yuan Zhang, Jie-Chao Yin, Hui Wang, Tian Sun, Li-Qun Chen, Fu-Liang Bai, Wei Wu, Gui-Ping Ren, De-Shan Li. Enhancement of Anti-tumor Activity of Newcastle Disease Virus by the Synergistic Effect of Cytosine Deaminase. Asian Pacific Journal of Cancer Prevention, 2013;14(12):7489-7496. （Impact Factor: 1.271） 19.Fuliang Bai, Hui Tian, Zeshan Niu, Mingyao Liu, Guiping Ren, Yinhang Yu, Tian Sun, Siming Li, Deshan LI. Chimeric anti-IL-17 full-length monoclonal antibody is a novel potential candidate for the treatment of rheumatoid arthritis. International Journal of molecular medicine, 2014, 33（3）: 711-721. （Impact Factor: 1.957） 20.Mo Guo, Li-Ming Xu, Bing Zhou, Jie-Chao Yin, Xian-Long Ye, Gui-Ping Ren, De-Shan Li. Anchored periplasmic expression (APEx)-based bacterial display for rapid and high-throughput screening of B cell epitopes. Biotechnology Letters（Biotechnol Lett）, 2014, 36（3）：609-616 （Impact Factor:1.853） 21.Yunzhou Wu, Shijun Yan, Zheng Lv, Lin Chen, Jingshu Geng, Jinjiao He, Qingzhong Yu, Jiechao Yin, Guiping Ren, Deshan Li. Recombinant Newcastle Disease virus Anhinga Strain (NDV/Anh-EGFP) for Hepatoma Therapy. Technology in Cancer Research and Treatment, 2014, 13 (2): 169-175. （Impact Factor:1.943） 22.Fuliang Bai, Zeshan Niu, Hui Tian, Siming Li, Zheng Lv, Tianyuan Zhang, Guiping Ren, Deshan Li. Genetically engineered Newcastle disease virus expressing interleukin 2 is a potential drug candidate for cancer immunotherapy. Immunology Letters（Immunol Lett.） 2014，159(1-2):36-46. （Impact Factor:2.337） 23.Zeshan Niu, Fuliang Bai, Tian Sun, Hui Tian, Dan Yu, Jiechao Yin, Siming Li, Tianhe Li, Hongwei Cao, Qingzhong Yu, Yunzhou Wu, Guiping Ren, Deshan Li. Recombinant Newcastle Disease virus Expressing IL15 Demonstrates Promising Antitumor Efficiency in Melanoma Model. Technology in Cancer Research and Treatment, 2014, online, Epub ahead print （Impact Factor:1.943） 24.Qingcui Li, Guiping Ren, Liming Xu, Qiuying Wang, Jianying Qi, Wenfei Wang, Bing Zhou，Xiaohui Han, Cuiyu Sun, Qiang Wu, Yinhang Yu, Zhongyi Peng, Shimin Zheng, Deshan Li. Therapeutic efficacy of three bispecific antibodies on collagen-induced arthritis mouse model. Int Immunopharmacol. 2014, 21(1): 119–127 ( Impact Factor:2.376) 25.Wen-Fei Wang, Si-Ming Li, Gui-Ping Ren, Wei Zheng, Yu-Jia Lu, Yin-Hang Yu, Wen-Juan Xu, Tian-He Li, Li-Hong Zhou, Yan Li, De-Shan Li. Recombinant murine fibroblast growth factor 21 ameliorate obesity-related inflammation in monosodium glutamate-induced obesity rats. Endocrine, 2014 ( Impact Factor: 3.527) 26.Fu-Liang Bai, Yin-Hang Yu, Hui Tian, Gui-Ping Ren, Hui Wang, Bing Zhou, Xiao-Hui Han, Qing-Zhong Yu & De-Shan Li. Genetically engineered Newcastle disease virus expressing interleukin-2 and TNF-related apoptosis-inducing ligand for cancer therapy. Cancer Biology & Therapy. 2014, 15(  9): 1226-1238 ( Impact Factor:3.63) 27.Xu L, Zhang Y, Wang Q, Zhao J, Liu M, Guo M, Jiang Y, Cao H, Li Q, Ren G, Li D. Bi-specific antibodies with high antigen-binding affinity identified by flow cytometry. Int Immunopharmacol. 2014, 24(2):463-473 ( Impact Factor: 2.711) 28.X. Ye, J. Qi, Y. Wu, D. Yu, P. Xu, S. Li, S. Zhu, Q. Wu, G. Ren, D. Li. Comparison of PEGylated FGF-21 with insulin glargine for long-lasting hypoglycaemic effect in db/db mice . Diabetes & Metabolism. 2015, 41(1):82-90 ( Impact Factor: 2.845) 29.F. L. Bai, H. Tian, Q. Z. Yu, G. P. Ren, and D. S. Li. Expressing Foreign Genes by Newcastle Disease Virus for Cancer Therapy. Molecular Biology. 2015, 49(2):171-178