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领域:生物产业 学校:东北农业大学职称:教授

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教育背景

1985.09-1989.07,中南民族大学,化学专业(本科) 1989.09-1992.07,东北农业大学,农药学专业(硕士) 1997.09-2001.07,中国农业大学,农药学专业(博士)

工作经历

1992.09-1995.09,东北农业大学,助教 1995.10-2000.09,东北农业大学,讲师 2000.10-2003.04,东北农业大学,副教授 2003.05-至今,东北农业大学,教授 2008.01-2013.12,东北农业大学,龙江学者特聘教授 2015.01-至今,东北农业大学,长江学者特聘教授

项目课题经历

论文、成果、著作等

发表SCI论文170余篇,申请或授权专利18项,代表论文如下: (1)Ji Zhang, Yi-Jun Yan, Jing An, Sheng-Xiong Huang, Xiang-Jing Wang, Wen-Sheng Xiang(). Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase. Microbial Cell Factories. 2015, 14: 152,SCI,IF=4.2 (2)Zhang Y, He H, Liu H, Wang H, Wang X, Xiang W(). Characterization of a pathway-specific activator of milbemycin biosynthesis and improved milbemycin production by its overexpression in Streptomyces bingchenggensis. Microb Cell Fact. 2016 Sep 7;15(1):152 SCI,IF=4.2 (3)Wang HY, Zhang J, Zhang YJ, Zhang B, Liu CX, He HR, Wang XJ, Xiang WS(). Combined application of plasma mutagenesis and gene engineering leads to 5-oxomilbemycins A3/A4 as main components from Streptomyces bingchenggensis. Appl Microbiol Biotechnol. 2014, 98(23):9703-12. SCI, IF3.811 (4)Ji Zhang, Jing An, Ji-Jia Wang, Yi-Jun Yan, Hai-Rong He, Xiang-Jing Wang, Wen-Sheng Xiang(). Genetic engineering of Streptomyces bingchenggensis to produce milbemycins A3/A4 as main components and eliminate the biosynthesis of nanchangmycin. Appl Microbiol Biotechnol. 2013 (97):1091-8 SCI, IF3.811 (5)Li C, Zhang Y, Liu C, Wang H, Zhao J, Li L, Zhang Z, Wang X, Xiang W(). Microbispora bryophytorum sp. nov., a novel actinomycete isolated from moss (Bryophyta). Int J Syst Evol Microbiol. 2015 65(4):1274-9 SCI 封面文章 (6)Wang HY, Zhang J, Zhang YJ, Zhang B, Liu CX, He HR, Wang XJ, Xiang WS(). Combined application of plasma mutagenesis and gene engineering leads to 5-oxomilbemycins A3/A4 as main components from Streptomyces bingchenggensis. Appl Microbiol Biotechnol. 2014, 98(23):9703-12. SCI, IF3.811 (7)Gao R, Liu C, Zhao J, Jia F, Yu C, Yang L, Wang X, Xiang W(). Micromonospora jinlongensis sp. nov., isolated from muddy soil in China and emended description of the genus Micromonospora, Antonie Van Leeuwenhoek, 2014,105(2):307-15 (SCI, IF2.137) ESI Highly Cited Papers(高被引论文) (8)Jiang L, Saavedra AN, Way G, Alanis J, Kung R, Li J, Xiang W(), Liao J. Specific substrate recognition and thioester intermediate determinations in ubiquitin and SUMO conjugation cascades revealed by a high-sensitive FRET assay. Mol Biosyst. 2014, 10(4):778-86 (SCI, IF3.21) (9)Ji Zhang, Jing An, Ji-Jia Wang, Yi-Jun Yan, Hai-Rong He, Xiang-Jing Wang, Wen-Sheng Xiang(). Genetic engineering of Streptomyces bingchenggensis to produce milbemycins A3/A4 as main components and eliminate the biosynthesis of nanchangmycin. Appl Microbiol Biotechnol. 2013 (97):1091-8 (SCI, IF3.811) Sheng-Xiong Huang, Xiang-Jing Wang, Yijun Yan, Ji-Dong Wang, Ji Zhang, Cong-Xi Liu, Wen-Sheng Xiang(), Ben Shen. Neaumycin: a New Macrolide from Streptomyces sp. NEAU-x211, Organic Letters, 2012, 14(5): 1254-7, (SCI, IF6.324)

专利、著作版权等

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