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丁晓东

领域:生物产业 学校:东北农业大学职称:教授

植物基因工程、分子生物学...

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教育背景

1983.9-1987.7, 安徽农业大学园艺系,园艺学(学士) 1987.9-1990.7, 东北农业大学园艺系,园艺学(硕士) 1994.9-1997.7, 东北林业大学林学院,植物学(博士)

工作经历

1990.7-1993.7,东北农业大学园艺系,助教 1993.8-1996.7,东北农业大学园艺系,讲师 1996.8-2000.4,东北农业大学园艺系,副教授(破格提升) 2000.5-2003.2,日本秋田县立大学(Akita Prefectural University)生物工程研究所, 日本学术振兴会(JSPS)海外特聘研究员。 研究方向:水通道蛋白分子的生物化学、生物物理学特性的研究。 2003.3-2006.10,美国佛罗里达大学(University of Florida)植物病理系博士后。 研究方向:水稻蛋白质组及相关蛋白激酶的信号途径。 2006.11-2016.3,美国德克萨斯大学西南医学中心(The University of Texas Southwestern Medical Center),资深研究员。 研究方向:蛋白质组,基因组及蛋白质激酶信号传导, 利用CRISPR/Cas9技术对基因组进行定点基因敲除和编辑。 2016年3月-现在,东北农业大学生命科学院,教授,博士生导师,植物学科带头人。 研究方向:蛋白质激酶信号传导及其在植物耐非生物胁迫中功能;利用CRISPR/Cas9技术对基因组进行精准编辑。

项目课题经历

论文、成果、著作等

【1】 Xiaodong Ding, Sandeep K. Barodi, Lisha Ma, Matthew S. Goldberg (2017) Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity. Neurobiology of Disease 98:122–136 (内容简介:利用酵母二元杂交技术首次鉴定到一个与LRRK2激酶有物理互作关系的泛素化连接酶基因Fbxl18,Co-IP技术确定这两个蛋白在动物细胞内具有特异的互作关系,同时Fbxl18能够介导LRRK2经过蛋白酶体途径进行降解,并且LRRK2的磷酸化是Fbxl18介导其降解的前提条件。由Fbxl18介导的LRRK2降解可以有效的抑制基因对细胞的毒害作用,从而使得Fbxl18和LRRK2成为药物作用靶点) 【2】 Xuewei Song,Huizi Duanmu,Yang Yu,Chao Chen,Xiaoli Sun,Pinghui Zhu,Ranran Chen,Xiangbo Duan,Huiqing Li,Lei Cao,Zaib un Nisa,Qiang Li,Yanming Zhu, Xiaodong Ding (2017) GsJ11, identified by genome-wide analysis, facilitates alkaline tolerance in transgenic plants. Plant Cell Tissue and Organ Culture. doi:10.1007/s11240-017-1188-5 (内容简介: 根据野生大豆的转录组谱的数据,发现了一个分子伴侣基因GsJ11能够被盐碱所正调控,转基因植物对盐碱表现出一定的抗性) 【3】Lei Cao, Yang Yu, Huizi DuanMu, Chao Chen, Xiangbo Duan, Pinghui Zhu, Ranran Chen, Qiang Li, Yanming Zhu, Xiaodong Ding (2016). A novel Glycine soja homeodomain-leucine zipper (HD-Zip) I gene, Gshdz4, positively regulates bicarbonate tolerance and responds to osmotic stress in Arabidopsis. BMC Plant Biol. 16: 184. (内容简介: 首次发现和报道了野生大豆GsHDZ4基因所具有的对碳酸钠碱性盐抗性方面的生理功能,为该基因在选育对盐碱有高抗性的农作物新品种提供了理论依据) 【4】Yang Yu, Ailin Liu, Xiangbo Duan, Sunting Wang, Xiaoli Sun, Huizi Duanmu, Dan Zhu, Chao Chen, Lei Cao, Jialei Xiao, Qiang Li, Zaib_un Nisa, Yanming Zhu, Xiaodong Ding (2016). GsERF6, an ethylene-responsive factor from Glycine soja, mediates the regulation of plant bicarbonate tolerance in Arabidopsis. Planta. 244: 681-98. (内容简介: 鉴定和发现了野生大豆基因GsERF6在植物中对盐碱胁迫的反应,并在拟南芥中表现出耐盐碱的生理功能) 【5】Xiaodong Ding, Tadashi Matsumoto, Patrizia Gena, Chengwei Liu, Marialuisa Pellegrini-Calace, Shihua Zhong, Xiaoli Sun, Yanming Zhu, Maki Katsuhara, Ikuko Iwasaki, Yoshichika Kitagawa, Giuseppe Calamita (2013). Water and CO2 permeability of SsAqpZ, the cyanobacterium Synechococcus sp. PCC7942 aquaporin. Biol Cell. 105: 118-28 (本人作为特邀讲员出席了2014年度日本第55届植物学大会并就此研究内容作了特邀口头报告) (内容简介: 首次以光合细菌PCC7942为模型,证明水通道蛋白具有二氧化碳气体通透特性,该菌系的水通道基因SsAqpZ的敲除显著抑制了细菌的二氧化碳的吸收和光合作用效率,为进一步研究植物的相关蛋白,提高植物光合作用提供了科学依据) 【6】Xiaodong Ding, Todd Richter, Mei Chen, Hiroaki Fujii, Mingtang Xie, Xianwu Zheng, Siddhartha Kanrar, Rebecca A. Stevenson, Christopher Dardick, Ying Li, Hao Jiang, Yan Zhang, Fahong Yu, Lihuang Zhu, William G. Farmerie, Michael Gribskov, Jian-Kang Zhu, Michael E. Fromm, Pamela C. Ronald, and Wen-Yuan Song (2009). A rice protein-kinase interaction network. Plant Physiology 149: 1478-1492. (引用的杂志包括Nature Reviews Molecular Cell Biology等权威杂志) (内容简介: 克隆了300条水稻蛋白激酶全长基因,运用高通量酵母二元杂交技术筛选了水稻cDNA文库,获得了500百多互作蛋白,构建了首个大规模水稻蛋白激酶-蛋白质互作数据库。) 【7】Xiaodong Ding, Matthew Goldberg (2009). Regulation of LRRK2 Stability by the E3 Ubiquitin Ligase CHIP. PLOS One 4: e5949 (引用的杂志包括Nature Reviews Neuroscience等权威杂志) (本项目研究成果被美国报纸媒体(CenterTimes)和网络所广泛报道 http://www.utsouthwestern.edu/utsw/cda/dept353744/files/535670.html) (内容简介: 利用酵母二元杂交技术筛选小鼠大脑cDNA文库,获得了帕金森症相关基因LRRK2的互作蛋白CHIP,生物化学研究表明CHIP具有E3泛素连接酶活性,并引导LRRK2到蛋白酶体消化分解,从而减轻病变LRRK2对细胞的毒害性) 【8】Xiaodong Ding, Yan Zhang, Wen-Yuan Song. (2007). Use of Rolling Circle Amplification for Large-scale Protein-Protein Interaction Studies. Methods in Molecular Biology, published by Humana Press, pp: 85-98. (内容简介: 系统描述了经过改进的基于Rolling Circle Amplification高通量大规模酵母二元杂交技术流程) 【9】Xiaodong Ding, Gina Cory, and Wen-Yuan Song. (2004). A high-throughput system to verify candidate interactors from yeast two-hybrid screening using rolling circle amplification. Analytical Biochemistry. 331: 195-197. (内容简介: 利用Rolling Circle Amplification成功地直接从酵母细胞中扩增出了环形质粒,并且扩增的质粒可以重新转入酵母中表达,从而为发明高通量酵母二元杂交提供了关键技术) 【10】Xiaodong Ding, Ikuko Iwasaki, Yoshichika Kitagawa. (2004). Overexpression of a lily PIP1 gene in tobacco increased the osmotic water permeability in the leaf cells. Plant Cell Environ. 27: 177–186. (内容简介: 百合花瓣中的水通道蛋白基因PIP1,在叶片原生质体中具有水孔蛋白的生化和生理活性,在烟草中过量表达可以显著提高植物的抗旱和干物质积累) 【11】Xiaodong Ding, Anita K. Snyder, Regina Shaw, William G. Farmerie, and Wen-Yuan Song. (2003). Direct retransformation of yeast with plasmid DNA isolated from single yeast colonies using rolling circle amplification. Biotechniques. 35: 774-779. 【12】Xiaodong Ding#, David Kozono#, Ikuko Iwasaki, Xianying Meng, Yoichi Kamagata, Peter Agre and Yoshichika Kitagawa. (2003). Functional expression and characterization of a novel archeael aquaporin, AqpM from Methanothermobacter Marburgensis. J. Biol. Chem. 278: 10649–10656. (#共同第一作者,通讯作者Peter Agre是2003年诺贝尔奖获得者,此论文是他获诺奖的部分成果并被收入他的获奖演说稿中)引用的杂志包括Nature Structure and Molecular Biology等权威杂志) 【13】Xiaodong Ding, Yoshichika Kitagawa. (2001). Rapid amplification of water channel-likegene and its flanking sequences from Methanobacterium thermoautotrophicum Marburg genome with single primer PCR strategy. J. Biosci. Bioeng. 92: 488-491. (IF: 2.31) 【14】Chengwei Liu, Tatsuya Fukumoto, Tadashi Matsumoto, Patrizia Gena, Giuseppe Calamita, Tomoyuki Kaneko, Maki Katsuhara, Shihua Zhong, Xiaoli Sun, Yanming Zhu, Xiaodong Ding, Ikuko Iwasaki, Yoshichika Kitagawa (2013). Aquaporin OsPIP1;1 promotes rice salt resistance and seed germination. Plant Physiol. Biochem. 63:151-158 【15】Yoshichika Kitagawa, Chengwei Liu, Xiaodong Ding (2011). The influence of natural mineral water on aquaporin water permeability and human natural killer cell activity. Biochem. Biophys. Res. Commun. 409:40-45.)(该文章被中文“生物谷”网站翻译,转载和评论(http://www.bioon.com/biology/ Immunology/515576.shtml) 【16】Xiaoli Sun, Hua Cai, Yong Li, Xi Bai, Wei Ji, Xiaodong Ding, Yanming Zhu (2012). The Arabidopsis AtbZIP1 transcription factor is a positive regulator of plant tolerance to salt, osmotic and drought stress. J. Plant Research 125(3):429-38 【17】Kuldip D. Dave, Shehan De Silva, Niketa P. Sheth, Sylvie Ramboz, Melissa J. Beck, Changyu Quang, Robert C. Switzer III, Syed Ahmad, Susan M. Sunkin, Dan Walker, Xiaoxia Cui, Daniel A. Fisher, Aaron M. McCoy, Kevin Gamber, Xiaodong Ding, Matthew S. Goldberg, Stanley A. Benkovic, Meredith Haupt, Marco A.S. Baptista, Brian K. Fiske, Todd B. Sherer, Mark A. (2014). Phenotypic characterization of recessive gene knockout rat models of Parkinson’s disease. Neurobiology of Disease. pii: S0969-9961(14)00173-9. 【18】Xiao Luo, Xiaoli Sun, Baohui Liu, Dan Zhu, Xi Bai, Hua Cai, Wei Ji, Lei Cao, Jing Wu, Mingchao Wang, Xiaodong Ding, Yanming Zhu (2013). Ectopic Expression of a WRKY Homolog from Glycine soja Alters Flowering Time in Arabidopsis. Plos One 8: e73295. 【19】 Xiao-Li Sun, Qing-Yue Yu, Li-Li Tang, Wei Ji, Xi Bai, Hua Cai, Xiao-Fei Liu, Xiao-Dong Ding, Yan-Ming Zhu (2013). GsSRK, a G-type lectin S-receptor-like serine/threonine protein kinase, is a positive regulator of plant tolerance to salt stress. J Plant Physiol. 170 (5): 505-515. 【20】De-Kang Lv, Xi Bai, Yong Li, Xiao-Dong Ding, Ying Ge, Hua Cai, Wei Ji, Nalahu Wu, Yan-Ming Zhu (2010). Profiling of cold-stress-responsive miRNAs in rice by microarrays. Gene 459(1-2):39-47. 【21】Xiaoli Sun, Wei Ji, Xiaodong Ding, Xi Bai, Hua Cai, Shanshan Yang, Xue Qian, Mingzhe Sun, Yanming Zhu (2013). GsVAMP72, a novel Glycine soja R-SNARE protein, is involved in regulating plant salt tolerance and ABA sensitivity. Plant Cell, Tissue and Organ Culture 113(2): 199-215 【22】 XiaoLi Sun, Mingzhe Sun, Xiao Luo, XiaoDong Ding, Wei Ji, Hua Cai, Xi Bai, XiaoFei Liu, YanMing Zhu (2013). A Glycine soja ABA-responsive receptor-like cytoplasmic kinase, GsRLCK, positively controls plant tolerance to salt and drought stresses. Planta. 237(6):1527-45. 【23】Sun, Xiaoli; Luo, Xiao; Sun, Mingzhe; Chen, Chao; Ding, Xiaodong; Wang, Xuedong; Ji, Wei; Bai, Xi; Cai, Hua; Yu, Qingyue; Yang, Shanshan; Zhu, Yanming (2014). A G. Soja 14-3-3 Protein GsGF14 Participates in Stomata and Root Hair Development and Drought Tolerance in Arabidopsis thaliana. Plant Cell Physiology 55(1):99-118. 【24】Yingnan Jiang, Xiuhua Chen, Xiaodong Ding, Yongsheng Wang, Qiang Chen, and Wen-Yuan Song (2013). The XA21 binding protein XB25 is required for maintaining XA21-mediated Disease Resistance. Plant J. 73(5):814-23. 【25】Nicholas G. James, Michelle A. Digman, Enrico Gratton, Barbara Barylko, Xiaodong Ding, Joseph P. Albenaesi, Matthew S. Goldberg, David M. Jameson (2012). Analysis of Oligomerization State of LRRK2 in Live Cells. Biophysical Journal. 102(11):L41-3 【26】Liya Pi, Xiaodong Ding, Marda Jorgensen, Jen-Jung Pan, Seh-Hoon Oh, Dana Pintilie, Alicia Brown, Wen-Yuan Song, and Bryon E. Petersen (2008). Connective Tissue Growth Factor with a Novel Fibronectin Binding Site Promotes Cell Adhesion and Migration During Rat Oval Cell Activation. Hepatology 47(3):996-1004 【27】Hong-Li Lian, Xin Yu, Qin Ye, Xiaodong Ding, Yoshichika Kitagawa, Sang-Soo Kwak, Wei-Ai Su and Zhang-Cheng Tang. (2004). The role of aquaporin RWC3 in drought avoidance in rice. Plant Cell Physiol. 45: 481-489. 【28】H.Y. Li, Y.M. Zhu, Q. Chen, R.L. Conner, X.D. Ding, J. Li, B.B. Zhang (2004). Production of transgenic soybean plants with two anti-fungal protein genes via Agrobacterium and particle bombardment. Biologia Plantarum 48 (3): 367-374 【29】 Xiuhua Chen, Xiaodong Ding, Wen-Yuan Song. (2003). Isolation of plasmid DNA rescued from single colonies of Agrobacterium tumefaciens by means of rolling circle amplification. Plant Mol. Biol. Reporter. 21: 411-415. 【30】Rafael Zardoya, Xiaodong Ding, Yoshichika Kitagawa and Maarten J. Chrispeels. (2002). Origin of plant glycerol transporters by horizontal gene transfer and functional recruitment. Proc. Natl. Acad. Sci. USA. 99: 14893-14896. (引用的杂志包括Nature等权威杂志) 【31】 Xiaoli Sun, Shanshan Yang, Mingzhe Sun, Sunting Wang, Xiaodong Ding, Wei Ji, Hua Cai, Chaoyue Zhao, Xuedong Wang, Yanming Zhu (2014). A novel Glycine soja cysteine proteinase inhibitor GsCPI14, interacting with the calcium/calmodulin-binding receptor-like kinase GsCBRLK, regulated plant tolerance to alkali stress. Plant Mol. Biol. 85(1-2):33-48

专利、著作版权等

【1】丁晓东,李国英,谭余,余泽源,濉薇,李光玉(1995)小浆果育种,吉林科学技术出版社 【2】 丁晓东,濉薇(1994)黑加仑和树莓栽培和加工技术,哈尔滨工程大学出版社 专利 利用RCA技术直接扩增酵母基因组DNA U.S. Patent Application No. 10/856,063, May 28, 2004
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