教育背景
2010年7月在中国人民解放军第四军医大学细胞工程技术研究中心和细胞生物学部/国家重点实验室获得医学博士学位,师从陈志南院士
工作经历
2010年10月至2012年10月,在美国西北大学Feinberg School of Medicine血液和癌症学部做博士后工作。与美国西北大学Chonghui Cheng研究小组成员及诺贝尔奖获得者Phil Sharp教授等一起研究发现CD44分子参与K ras-诱导的肺腺癌发病过程
项目课题经历
国家自然科学基金青年基金项目:CD44调控肝癌细胞侵袭伪足形成及其机制的研究 (31301108)
论文、成果、著作等
代表性论文
1. Zhao P, Damerow MS, Stern P, Liu AH, Sweet-Cordero A, Siziopikou K, Neilson JR, Sharp PA, Cheng C. CD44 promotes Kras-dependent lung adenocarcinoma. Oncogene. 2012 Dec 3. doi: 10.1038/onc.2012.542.
2. Zhao P, Zhang W, Wang SJ, Yu XL, Tang J, Huang W, Li Y, Cui HY, Guo YS, Tavernier J, Zhang SH, Jiang JL, Chen ZN. HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in HCC cells. Hepatology. 2011;54(6):2012-2024.
3. Zhao P, Zhang W, Tang J, Ma XK, Dai JY, Li Y, Jiang JL, Zhang SH, Chen ZN. Annexin II promotes invasion and migration of human hepatocellular carcinoma cells in vitro via its interaction with HAb18G/CD147. Cancer Science. 2010;101(2):387-395.
4. Cui HY, Guo T, Wang SJ, Zhao P, Dong ZS, Zhang Y, Jiang JL, Chen ZN, Yu XL. Dimerization is essential for HAb18G/CD147 promoting tumor invasion via MAPK pathway. Biochemical and Biophysical Research Communications. 2012;419 (3):517-522.
5. Ma XK, Wang L, Li Y, Yang XM, Zhao P, Tang H, Zhu P, Li L, Chen ZN HAb18G/CD147 cell-cell contacts confer resistance of a HEK293 subpopulation to anoikis in an E-cadherin-dependent manner. BMC Cell Biology. 2010;11(1):27.
6. Dai JY, Dou KF, Wang CH, Zhao P, Lau WB, Tao L, Wu YM, Tang J, Jiang JL, Chen ZN. The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells. BMC Cancer. 2009;9:337.
7. Tang J, Wu YM, Zhao P, Jiang JL, Chen ZN. Betaig-h3 interacts with alpha3beta1 integrin to promote adhesion and migration of human hepatoma cells. Experimental Biology and Medicine (Maywood). 2009;234(1):35-39.ecine
8. Wu YM, Tang J, Zhao P, Chen ZN, Jiang JL. Morphological changes and molecular expressions of hepatocellular carcinoma cells in three-dimensional culture model. Experimental and Molecular Pathology. 2009;87(2):133-140.
9. Wu YM, Tang J, Zhao P, Chen ZN, Jiang JL. Enhanced expression of Hab18g/CD147 and activation of integrin pathway in HCC cells under 3-D co-culture conditions. Cell Biology International. 2009;33(2):199-206.
10. Tang J, Wu YM, Zhao P, Yang XM, Jiang JL, Chen ZN. Overexpression of HAb18G/CD147 promotes invasion and metastasis via alpha3beta1 integrin mediated FAK-paxillin and FAK-PI3K-Ca2+ pathways. Cell Molecular Life Science. 2008;65(18):2933-2942.
专利、著作版权等
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