1992.02—1995.07中国农业大学分子生物学及生物化学专业，博士。 导师：阎隆飞教授（中国科学院院士） 1986.09—1989.07沈阳农业大学生物化学专业，硕士。 导师：曹淡君教授 1982.09—1986.07东北师范大学生物学专业，学士

2013.03——至今 大连医科大学重大疾病基因工程模式动物研究所 教授，所长 2012.12—至今 美国纽约大学口腔医学院基础科学与颅面生物学系 研究员， 兼职教授 2011.09—至今 美国西奈山医学院内分泌、糖尿病及骨疾病系 兼职副教授 2005.09—2011.08 美国西奈山医学院内分泌、糖尿病及骨疾病系 研究副教授 2002.02—2005.03 美国国立健康卫生研究院心肺血液研究所 资深研究员 1999.01—2002.02 美国宾夕法尼亚大学生物系 研究助理 1989.07—1992.02 辽宁师范大学食品生化所 讲师

1、国家自然科学基金面上项目：组织特异性敲除GHR基因在β细胞功能中的作用机制研究，项目编号81471000，78万元，2015.01-2018.12，主持 2、国家国际科技合作专项项目：利用新的高效基因打靶技术建立人类重大疾病动物模型，项目编号2014DFA32120，456万，2014.04-2017.03，主持 3、辽宁省科技计划项目：基因工程实验动物新品系及人类重大疾病动物模型研发，项目编号201402893，20万元，2014.04-2017.03，主持 4、辽宁省省自然科学基金优秀人才培育项目ᠦ୔

[1] Zhang Y, Zou X, Qian W, Weng X, Zhang L, Zhang L, Wang S, Cao X, Ma L, Wei G#, Wu Y#, Hou Z#. Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cellmigration and metastasis. Cell Death Differ, 2018, [Epub ahead of print]. [2] Tao Yu, Chunxin Wang, Jian Yang, Yuqi Guo, Yingjie Wu# and Xin Li#. Metformin inhibits SUV39H1-mediated migration of prostate cancer cells. Oncogenesis， (2017) e324; doi:10.1038. [3] Yuqi Guo, Chengzhi Xie, Xiyan Li, Jian Yang, Yu Tao, Tianqing Zhang, Michael Snyder, Yingjie Wu and Xin Li#. Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis. Nature Communications， 2017 May 31;8:15621. [4] Jinhui Yu, Yong Ma, Jie Sun, Liyuan Ran, Youwei Li, Ning Wang, Tao Yu, Wenting Gao, Wenbin Jia, Rujiao Jiang, Meihua Guo, Yuping Bi# and Yingjie Wu# Microalgal oil from Schizochytrium sp. prevents HFD-induced abdominal fat accumulation in mice. Journal of the American College of Nutrition， 2017 May 26:1-10. [5] Yiwen Qin, Yuanzhen Peng, Wei Zhao, Jianping Pan, Hanna Ksiezak-Reding, Christopher Cardozo, Yingjie Wu, Paola Divieti Pajevic, Lynda F. Bonewald, William A Bauman and Weiping Qin. Myostatin Inhibits Osteoblastic Differentiation by Suppressing Osteocyte-derived Exosomal microRNA-218: A Novel Mechanism in Muscle-Bone Communication. J Biol Chem， 2017;292(26):11021-11033. PMID: 28465350 [6] Yuqi Guo, Tao Yu, Jian Yang, Tianqing Zhang, Yang Zhou, Fan He, Zoya Kurago, David Myssiorek, Yingjie Wu, Peng Lee, Xin Li Metformin inhibits salivary adenocarcinoma growth through cell cycle arrest and apoptosis. Am J Cancer Res 2015，5 (12):3600-3611 [7] Weiping Qin, Xiaodong Li, Yuanzhen Peng, Lauren M Harlow, Yinshi Ren, Yingjie Wu, Jiliang Li, Yiwen Qin, Jie Sun, Tom Brown, Jian Q. Feng, Hua Zhu Ke, William A Bauman, Christopher C Cardozo. Sclerostin Antibody Preserves the Morphology and Structure of Osteocytes and Blocks the Severe Skeletal Deterioration after Motor-Complete Spinal Cord Injury in Rats. Journal of Bone and Mineral Research. 2015, 30(11):1994–2004 [8] Zhenwei Gong*, Oran Kennedy*, Hui Sun*, Yingjie Wu*, Garry A Williams, Laura Klein, Luis Cardoso, Ronald W. Matheny Jr, Gene B. Hubbard, Yuji Ikeno, Roger P. Farrar, Mitchell B Schaffler, Martin L Adamo, Radhika H Muzumdar1 and Shoshana Yakar, Reductions in serum IGF-1 during aging impair health span. Aging Cell, 2014, 13, 408–418. [9] Kennedy OD, Sun H, Yingjie Wu, Courtland HW, Williams GA, Cardoso L, Basta-Pljakic J, Schaffler MB, Yakar S. Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene. Endocrinology, 2014, 155(3):987-999. [10] Yingjie Wu, Hui Sun, JelenaBasta-Pljakic, Luis Cardoso, Oran D Kennedy, Hector Jasper, HoracioDomené, Liliana Karabatas, Clara Guida, Mitchell B Schaffler, Clifford J Rosen, Shoshana Yakar, Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor. Journal of Bone and Mineral Research, 2013, 28(7),1575-1586. [11] Vijayakumar A, Buffin NJ, Gallagher EJ, Blank J, Yingjie Wu, Yakar S, Leroith D. Deletion of Growth Hormone Receptors in Post-Natal Skeletal Muscle of Male Mice Does Not Alter Muscle Mass and Response to Pathological Injury. Endocrinology，2013 , 154(10):3776-3783. [12] Tunde Akinyeke,Satoko Matsumura, Xinying Wang, Yingjie Wu, Eric D.Schalfer, AnjanaSaxena, Wenbo Yan, SusanK.Logan and Xin Li. Metformin targets c-MYC oncogene to prevent prostate cancer. Carcinogenesis, 2013, 134(12): 2823-2832. [13] Courtland HW, Kennedy OD, Yingjie Wu, Gao Y, Sun H, Schaffler MB, Yakar S. Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging. Age, 2013,，35(5), 1691-1703. [14] ArchanaVijayakumar*, Yingjie Wu*, ChengyuLiu,Hui Sun, Shoshana Yakar and Derek LeRoith, Targeted loss of GHR signaling in mouse skeletal muscle protects from high-fat diet-induced metabolic deterioration. Diabetes, 2012, 61(1):94-103. [15] ArchanaVijayakumar, Yingjie Wu, Buffin NJ, Li X, Sun H, Gordon RE, Shoshana Yakar, Derek LeRoith. Skeletal muscle growth hormone receptor signaling regulates Basal, but not fasting-induced, lipid oxidation. PLoS ONE, 2012，7(9):e44777. [16] Yingjie Wu, ChengyuLiu,Hui Sun, ArchanaVijayakumar, PejmanRaeisiGiglou, Joshua Oppenheimer, Shoshana Yakar and Derek LeRoith.Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. The Journal of Clinical Investigation, 2011, 121(6):2422–2426. [17] Sebastien Elis*, Yingjie Wu*, Hayden-William Courtland, Dara Cannata, Hui Sun, Mordechay Beth-On, Hector Jasper, HoracioDomené, Liliana Karabatas, Clara Guida, JelenaBasta-Pljakic, Luis Cardoso, Clifford J Rosen, and Shoshana Yakar. Unbound (bioavailable) IGF1 enhances somatic growth. Disease Models & Mechanisms, 2011 ,4(5):649-658. [18] Sebastien Elis, Yingjie Wu, Hayden-William Courtland, Hui Sun, Clifford J Rosen, Adamo ML and Shoshana Yakar. Increased serum IGF-1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 gene expression. Aging Cell, 2011, 27.(10) 1474-9726. [19] Hayden-William Courtland, Sebastien Elis, Yingjie Wu, Hui Sun, Clifford J Rosen, Karl J. Jepsen and Shoshana Yakar. Serum IGF-1 Affects Skeletal Acquisition in a Temporal and Compartment-Specific Manner. PLoS ONE, 2011, 6(3): e14762. [20] Hayden-William Courtland, Hui Sun, Mordechay Beth-On,Yingjie Wu, Sebastien Elis, Clifford J Rosen and Shoshana Yakar. Growth hormone mediates pubertal skeletal development independent of hepatic IGF-1 production. Journal of Bone and Mineral Research, 2011, 26(4): 761–768. [21] Guo-Ying Huang, Li-Jian Xie, Kaari L. Linask, Chen Zhang, Xiao-Qing Zhao, Yi Yang, Guo-Min Zhou, Yingjie Wu, Lucrecia Marquez-Rosado, Doff B. McElhinney, Elizabeth Goldmuntz, Chengyu Liu, Paul D. Lampe, Bishwanath Chatterjee, and Cecilia W. Lo. Evaluating the role of connexin43 in congenital heart disease: Screening for mutations in patients with outflow tract anomalies and the analysis of knock-in mouse models. J Cardiovasc Dis Res, 2011, 2(4): 206–212. [22] Yingjie Wu, Pnina Brodt, Hui Sun, Wilson Mejia, RuslanNovosyadlyy, Nomeli Nunez, Xiaoli Chen, Arnulfo Mendoza, Sung-Hyeok Hong, Chand Khanna and Shoshana Yakar.Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis. Cancer Research，2010, 70(1):57-67. [23] Dara Cannata, Danielle Lann, Yingjie Wu, Sebastien Elis, Hui Sun, Shoshana Yakar, Deborah A. Lazzarino, Teresa L. Wood and Derek LeRoith, Elevated Circulating IGF-1 Promotes Mammary Gland Development and Proliferation. Endocrinology, 2010, 151(12): 5751-5761. [24] Sebastien Elis, Hayden-William Courtland, Yingjie Wu, J. Christopher Fritton, HuiSun, Clifford J Rosen and Shoshana Yakar. Elevated serum IGF-1 levels synergize PTH action on the skeleton only when the tissue IGF-1 axis is intact. Journal of Bone and Mineral Research, 2010, 25(9):2051-8. 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Journal of Bone and Mineral Research, 2010, 25(2):235-246. [28] Shoshana Yakar, Clifford J. Rosen, Mary L. Bouxsein, Hui Sun, Wilson Mejia, Yuki Kawashima, Yingjie Wu, Kelly Emerton, Valerie Williams, Karl Jepsen, Mitchell B. Schaffler, Robert J. Majeska, Oksana Gavrilova, Mariana Gutierrez, David Hwang, Patricia Pennisi, Jan Frystyk, Yves Boisclair, John Pintar, Héctor Jasper, HoracioDomene, Pinchas Cohen, David Clemmons and Derek LeRoith. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. The FASEB Journal, 2009, 23(3):709-719. [29] Yingjie Wu, Hui Sun, Shoshana Yakar, Derek LeRoith. Elevated levels of IGF-1 in serum rescue the severe growth retardation of IGF-1 null mice. Endocrinology, 2009,150(9):4395-4403. [30] Yingjie Wu, Chunxin Wang, Hui Sun, Derek LeRoith and Shoshana Yakar. High-Efficient FLPo Deleter Mice in C57BL/6J Background. PLoS ONE, 2009, 4(11): e8054. [31] Xiao-Ning Zhang*, Yingjie Wu*, John Tobias, Brian Brunk, Gerald Deitzer, Dongmei Liu. HFR1 is crucial for transcriptome regulation in cryptochrome 1-mediated early response to blue light in Arabidopsis thaliana. PLoS ONE, 2008,3(10): e3563, (*Co-first authors). [32] Yuka Toyoshima, Christopher Monson, CunmingDuan, Yingjie Wu, Chuan Gao, Shoshana Yakar, Kirsten C. Sadlerand Derek LeRoith. The role of insulin receptor signaling in zebrafish embryogenesis. Endocrinology,2008,149(12):5996-6005. [33] Jinhui Zhang, Yingjie Wu, Yuanyuan Zhang, Derek LeRoith, David A. Bernlohr and Xiaoli Chen. The Role of Lipocalin 2 in the Regulation of Inflammation in Adipocytes and Macrophages. Molecular Endocrinology, 2008, 22(6):1416-26. [34] Charlie Xiang, Yingjie Wu. Li Ma, L. Ding &I. Lisinski, M. J. Brownstein,Samuel W Cushman and Xiaoli Chen. Characterisation of insulin-resistant phenotype of cultured rat primary adipose cells. Diabetologia, 2007, 50(5):1070-1079. [35] Qing Yu, Y. Shen, B. Chatterjee, B. H. Siegfried, L. Leatherbury, J. Rosenthal, J. F. Lucas, A. Wessels, C. F. Spurney, Yingjie Wu, M. L. Kirby, K. Svenson and C. W. Lo. ENU induced mutations causing congenital cardiovascular anomalies. Development, 2004,131(24):6211-6223. [36] Hongquan Yang, Yingjie Wu, Dongmei Liu, Ruhang Tang and Anthony R. Cashmore. The C-terminal of Arabidopsis cryptochrome mediate a constitutive light response. Cell, 2000,103: 815-827. [37] Anthony R. Cashmore, Jarillo, J. A., Yingjie Wu and Dongmei Liu. Cryptochromes: Blue Light Receptors for Plant and Animals. Science, 1999, 284: 760-765. 2、综述论文 [1] Shuang Wang, Jin Wu, Ning Wang, Li Zeng and Yingjie Wu, The Role of Growth Hormone Receptor on β Cell Function. Growth Hormone & IGF Research, 2017, 36:30-35. (# Correspondence author) [2] ArchanaVijayakumar, RuslanNovosyadlyy, Yingjie Wu, Shoshana Yakar and Derek LeRoith. Biological effects of growth hormone on carbohydrate and lipid metabolism. 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吴英杰，景作磊等。 一种细胞DNA损伤修复的抑制剂 (专利申请号等待中)[1] GENOME EDITING and ENGINEERING: From Talens, ZFNs and CRISPRs to Molecular Surgery. edited by Dr. Krishnarao Appasani, Cambridge University Press 2017 (One Chapter: Genome editing with desired mutations (knock-in) wᠦ୔