本科毕业于华东师范大学生命科学学院生物技术系，同年保送至上海交通大学药学院攻读硕士和博士学位。2012年初获得生物药学方向博士学位。

国家自然科学基金面上项目，“Nmi通过负调控人端粒酶逆转录酶抑制乳腺癌发生发展的作用机制和临床意义”（81772975），项目负责人 国家自然科学基金面上项目，“SPT6通过上调hTERT表达促进结肠癌发生发展的分子作用机制和临床意义”（81572706），项目负责人 国家自然科学基金青年基金项目，“CPSF4调控hTERT表达及在肺癌发生发展中的作用机制和临床意义”（81301721），项目负责人 辽宁省自然科学基金项目，“SPT6/hTERT信号通路参与结肠癌发生发展的功能与分子机制研究”（20150ᠦ୔

1. Zhao X, Zheng F, Li Y, Hao J, Tang Z, Tian C, Yang Q, Zhu T, Diao C, Zhang C, Chen M, Hu S, Guo P, Zhang L, Liao Y, Yu W, Chen M, Zou L, Guo W*,Deng W. BPTF promotes hepatocellular carcinoma growth by modulating hTERT signaling and cancer stem cell traits. Redox Biol. 2019, 20:427- 441. 2. Hao J, Xu H, Luo M, Yu W, Chen M, Liao Y, Zhang C, Zhao X, Jiang W, Hou S, Feng X, Zou K, Chen Y, Huang W, Guo W*,Kang L, Deng W. The Tumor-Promoting Role of TRIP4 in Melanoma Progression and its Involvement in Response to BRAF-Targeted Therapy. J Invest Dermatol. 2018, 138(1):159-170. 3.Feng X, Xu X, Xiao X, Zou K, Yu W, Wu J, Tang R, Gao Y, Hao J, Zhao X, Liao Y, Chen Y, Huang W, Guo W*,Kang L, Deng W. NMI inhibits cancer stem cell traits by downregulating hTERT in breast cancer. Cell Death Dis. 2017, 8(5):e2783. 4.Yi C, Wang Y, Zhang C, Xuan Y, Zhao S, Liu T, Li W, Liao Y, Feng X, Hao J, Gao Y, Yu W, Chen Y, Zhang C, Guo W*,Tang B, Deng W. Cleavage and polyadenylation specific factor 4 targets NF-κB/cyclooxygenase-2 signaling to promote lung cancer growth and progression. Cancer Lett. 2016, 381(1):1-13. 5. Tang Z, Yu W, Zhang C, Zhao S, Yu Z, Xiao X, Tang R, Xuan Y, Yang W, Hao J, Xu T, Zhang Q, Huang W, Deng W, Guo W*.CREB-binding protein regulates lung cancer growth by targeting MAPK and CPSF4 signaling pathway. Mol Oncol. 2016 ,10(2):317-29. 6. Tang R, Xu X, Yang W, Yu W, Hou S, Xuan Y, Tang Z, Zhao S, Chen Y, Xiao X, Huang W,Guo W*,Li M, Deng W. MED27 promotes melanoma growth by targeting AKT/MAPK and NF-κB/iNOS signaling pathways. Cancer Lett. 2016, 373(1):77-87. 7. Xuan Y, Wang J, Ban L, Lu JJ, Yi C, Li Z, Yu W, Li M, Xu T, Yang W, Tang Z, Tang R, Xiao X, Meng S, Chen Y, Liu Q, Huang W,Guo W*,Cui X, Deng W. hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers. Mol Oncol. 2016, 10(4):610-24. 8.Guo W#，*，Lu J，Dai M，Wu T，Yu Z，Wang J，Chen W，Shi D，Yu W，Xiao Y，Yi C，Tang Z，Xu T，Xiao X，Yuan Y，Liu Q，Du G，Deng W. Transcriptional coactivator CBP upregulates hTERT expression and tumor growth and predicts poor prognosis in human lung cancers. Oncotarget，2014，5（19）：9349-9361. 9.Guo W#，Li D，Zhu JA，Wei X，Men W，Yin D，Fan M，Xu Y. A Magnetic Nanoparticle Stabilized Gas Containing Emulsion for Multimodal Imaging and Triggered Drug Release. Pharm Res. 2014，31（6）：1477-1484. 10. Yu Z#，Guo W#，Ma X ，Zhang B，Dong P，Huang L，Wang X，Huo X，Yu W，Yi C，Xiao Y，Yang W，Qin Y，Yuan Y，Meng S，Liu Q，Deng W. Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells. Mol Cancer，2014，13（203）：1-14. 11. Yi C，Zhang Y，Yu Z，Xiao Y，Wang J，Qiu H，Yu W，Tang R，Yuan Y，Guo W*，Deng W*. Melatonin Enhances the Anti-Tumor Effect of Fisetin by Inhibiting COX-2/iNOS and NF-kB/p300 Signaling Pathways. Plos One，2014，9（7）：1-11. 12. Wang J#，Guo W#，Chen W，Yu W，Tian Y，Fu L，Shi D，Tong B，Xiao X，Huang W，Deng W. Melatonin potentiates the anti-proliferative and pro-apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways. J Pineal Res. 2013，54（4）：406-416. 13.Guo W#，Liu S，Peng J，Wei X，Sun Y，Xu Y. Examining the interactome of Huperzine A by magnetic biopanning. Plos One，2012，7（5）：1-11. 14.Guo W#，Azhar MA，Xu Y，Wright M，Kamal A，Miller AD. Isolation and identification of diadenosine 5’,5’’’-P1,P4-tetraphosphate binding proteins using magnetic bio-panning. Bioorg Med Chem Let.. 2011，21（23）：7175-7179.