教育背景
1997年毕业于大连交通大学化学系,2001年考取大连交通大学环境与科学专业硕士研究生,2004年获硕士学位,2005年赴美国加州大学戴维斯分校医学院生理及膜生物学系郑劼教授实验室学习,进行温度敏感TRP离子通道的异源组装研究,2009年在郑劼教授指导下开始博士研究生学习,2012年获博士学位后,
工作经历
项目课题经历
1.国家自然科学基金青年项目,“温度敏感TRP离子通道蛋白参与调控人类黑素瘤发生发展的机制研究”,项目负责人。
2. 国家自然科学基金海外及港澳学者合作项目,“温度敏感TRP离子通道调控温度感觉的分子机制”,国内合作人。
论文、成果、著作等
1. Yang. F., X. Xiao ,W. Cheng, W. Yang , P. Yu , Z. Song , V. Yarov-Yarovoy,J. Zheng. Structural mechanism underlying capsaicin binding and activation of nociceptive TRPV1 ion channel.Nature Chemical Biology11:518-524, 2015
2.Cheng, W., F. Yang, S. Liu. C.K. Colton, Y. Cui, X. Cao, M.X. Zhu, C.Sun, K.Wang, J. Zheng, Heteromeric Heat-Sensitive TRP Channels Exhibit Distinct Temperature and chemical activation,Journal of Biological Chemistry,287:7279-7288,2012
3.Cheng, W., J. Liu, C. Sun, and J. Zheng, Temperature-Sensitive ThermoTRPs Ion Channels as Novel Drug Targets for Neuropathic Pain,Progress in Physiological Sciences, 43(2):125-130,2012
4.Cheng, W., F. Yang, C.L. Takanishi, and J. Zheng Thermosensitive TRPV channel subunits co-assemble into heteromeric channels with intermediate conductance and gating properties,Journal of General Physiology, 129, 191-207. 2007封面文章
5. Dong, B.*,W. Cheng*, W. Li, J. Zheng, F. Matsumura, and C. F. A.Vogel. FRET analysis of protein tyrosine kinase Src activation by TCDD in HepG2 and MC10A cells.Biochimica et Biophysica Acta - General Subjects,1810(4): 427-431,2011(* co-first authors)
6.Cheng, W., C. Sun, and J. Zheng, Heteromerization of TRP channel subunits: extending functional diversity,Protein &Cell, 1(9): 802–810,2010
7. Qu, Z.*,W. Cheng*, Y. Cui, Y. Cui, and J. Zheng.Human disease-causing mutations disrupt an N-C terminal interaction and channel function of bestrophin 1,Journal of Biological Chemistry, 284:16473-16481,2009 (* co-first authors)
8.Vetter, I., W. Cheng, M. Peiris, B.D. Wyse, S.J Roberts-Thomson, J. Zheng, G.R. Monteith1, and P.J. Cabot1.Rapid, opioid-sensitive mechanisms involved in TRPV1 sensitization ,Journal of Biological Chemistry, 283, 19540-19550,2008
专利、著作版权等
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