1999年 博士 中国预防医学科学院，病原生物学专业 1996年 硕士 卫生部兰州生物制品研究所，微生物学和免疫学专业 1990年 学士 兰州大学生物系，生物化学专业

2012-至今 教授 大连医科大学 2008-2013 研究员 中国科学院纳米生物效应与安全性重点实验室 2004-2007 研究员 美国国立卫生研究院，国立癌症研究所，生物化学和分子生物学实验室 1999-2004 博士后 美国国立卫生研究院，国立癌症研究所，生物化学和分子生物学实验室 1990-1993 医学生物工程助理工程师 卫生部兰州生物制品研究所

1. 国家自然科学基金面上项目，“DNA损伤修复和端粒保护重要因子Mre11的甲基化修饰及其功能”。 2. 国家科技部重大科学研究计划“973”项目，“基于纳米技术的药物新剂型改善肿瘤治疗效果的应用基础研究”。 3. 国家自然科学基金面上项目，“microRNA调节肿瘤抑制因子Caliban应答DNA损伤的机制”。

1. Cong, W., Wang, P., Qu, Y., Tang, J., Bai, R., Zhao, Y., Chen, C.,Bi, X.* Evalutation of the influence of Fullerenol on aging and stress resistance using Caenorhabditis elegans.Biomaterials.2015. 42:78-86. IF 8.3 2. YuanQ., Han J., CongW., Ge Y., Ma D., Dai Z., LiY.,Bi X.* Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with improved cell apoptosis and gene expression profile and reduced myelosuppression toxicity.Int J Nanomed. 2014. 9(1): 4829-4846. IF 4.2 3.Xie Q., Peng S., Tao L., Ruan H., Yang Y., Li TM., Adams U., Meng S., Bi X., Dong MQ., Yuan Z. E2F Transcription Factor 1 Regulates Cellular and Organismal Senescence by Inhibiting Forkhead Box O Transcription Factors.J Biol Chem. 2014 289(49):34205-34213. IF 4.6 4. Chen, H., Wang, B., Feng, W., Du, W., Ouyang, H., Chai, Z.,Bi, X.* Oral Magnetite Nanoparticles Disturb the Development ofDrosophila Melanogasterfrom Oogenesis to Adult Emergence.Nanotoxicology. 2014 Jun 25:1-11. [Epub ahead of print] doi:10.3109/17435390.2014.929189. IF 7.8 5. Fang, G., Zhang, D., Yin, H., Zheng, L.,Bi, X.*, Yuan, L.* Centlein maintains centrosome cohesion by bridging an interaction between C-Nap1 and Cep68.J Cell Sci. 2014. 127 (Pt 8):1631-1639. IF 5.9 6. Wang, Y., Wang, Z., Joshi, BH., Puri, R., Stultz, B., Yuan, Q., Bai, Y., Zhou, P., Yuan, Z., Hursh, DA.,Bi, X.* The tumor suppressor Caliban regulates DNA damage induced apoptosis through p53-dependent and –independent activity.Oncogene. 2013. 32(33):3857-3866. IF 8.6 7. Liu, W., Jiang, F.,Bi, X.*, Zhang, Q.*DrosophilaFMRP participates in DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis.Human Molecular Genetics. 2012. 21(21):4655-4668. IF 7.7 8. Kong, L., Yuan Y., Zhu, H., Li, Y., Guo, Q., Zhao, Y., Wang, Q.,Bi, X.*, Gao,X.* The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis.Biomaterials.2011. 32(27)：6515-6522. IF 7.6 9. Wang, P., Bai, Y., Song, B., Wang, Y., Liu, D., Lai, Y.,Bi, X.*, Yuan, Z.* PP1A-mediated dephosphorylation positively regulates YAP2 activity.PLoS ONE. 2011.6(9):e24288. IF 4.3 10.Gao, G.,Bi, X., Chen, J., Srikanta, D., Rong, YS. Mre11-Rad50-Nbs complex is required to cap telomeres duringDrosophilaembryogenesis.Proc. Nat. Acad. Sci. USA.2009.106(26): 10728–10733. (Equal contribution). IF 9.8 11.Bi, X., Jones, T.,Abbasi, F., Lee,H., Stultz, B., Hursh,D., Mortin, M.DrosophilaCaliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. Oncogene. 2005.24:8229-8239. IF 6.9 12. Bi, X., Srikanta, D., Fanti,L., Pimpinelli,S., Badugu,R., Kellum,R., Rong, Y.S.DrosophilaATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. Proc. Nat. Acad. Sci. USA. 2005.102(42):15167-15172. IF 9.8 13. Bi, X., Gong, M., Srikanta, D., Rong, Y.S.DrophilaATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation.Genetics.2005. 171:845-847. IF 4.3 14. Bi, X., Wei, S.D., Rong, Y.S. Telomere protection without a telomerase: the role of ATM and Mre11 inDrosophilatelomere maintenance. Curr Biol.2004. 14:1348-1353. IF 11.9 15. Bi, X., Kajava, A., Demidenko, Z., Jones, T., Mortin, M. The carboxyl terminus of Prospero regulates its subcellular localization. Mol Cell Biol. 2003.23 (3): 1014-1024. IF 8.9