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孟松树

领域:生物产业 学校:大连医科大学职称:教授

(1)溶瘤病毒的临床前研究 (2)细胞自噬与肿瘤的发生发展 (3)Hippo/YAP信号通路、Spred2/Ras/Raf信号通路与肿瘤...

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教育背景

1997.9-2000.7:中国农业科学院哈尔滨兽医研究所,兽医生物技术国家重点实验室,博士 1991.9-1994.6:扬州大学 (原江苏农学院),兽医微生物专业, 硕士 1984.9-1989.6:扬州大学 (原江苏农学院),兽医专业, 学士

工作经历

2012.10--至今:大连医科大学,肿瘤干细胞研究院,教授 2004.7- 2012.9:扬州大学,生物科学与技术学院,副教授 2001.6-2004.6:美国南佛罗里达大学,H Lee Moffitt肿瘤研究中心,博士后 2000.8 -2001.5:浙江大学,讲师

项目课题经历

(1)国家自然科学基金面上项目(2014-2017) 溶瘤新城疫病毒通过自噬效应杀伤耐药肺癌细胞的分子机制及应用 (2)国家自然科学基金面上项目(2016-2019) 抑癌蛋白SASH1调控Hippo/YAP通路在乳腺癌发生发展中的作用和机制 (3)大连医科大学其震工程人才项目(2013-2017)

论文、成果、著作等

1.Jiang K, Liu M, Lin G, Mao B, Cheng W, Liu H, Jozsef G, Zhu H, Yuan Z, Deng W, Liu Q, Gong P, Bi X,Meng S*. Tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death. Oncotarget. (Accepted, March 12, 2016) (*通讯作者 ) IF: 6.4 2. Li Z,Jiang K, Zhu X, Lin G, Song F, Zhao Y, Piao Y, Liu J, Cheng W, Bi X, Gong P, Song Z,Meng S*. Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells. Cancer Lett. 2015 Nov 13.(*通讯作者 ) IF: 5.6 3. Lulu Hu, Sulan Sun, Tianpeng Wang, Yingchun Li, Ke Jiang, Guibin Lin, Yan Ma, Martin P. Barr, Fei Song, Guirong Zhang,Songshu Meng*. Oncolytic Newcastle Disease Virus triggers cell death of lung cancer spheroids and is enhanced by pharmacological inhibition of autophagy. American Journal Cancer Research. 2015;5(12):3612-23 (*通讯作者) IF: 4.1 4. Song Q, Mao B, Cheng J, Gao Y1,Jiang K, Chen J, Yuan Z,Meng S*. YAP enhances autophagic flux to promote breast cancer cell survival in response to nutrient deprivation. PLoS One. 2015 Mar 26; 10(3)(*通讯作者 ) IF: 3.6 5. Jiang K, Li Y, Zhu Q, Xu J, Wang Y, Deng W, Liu Q, Zhang G, Meng S* Pharmacological modulation of autophagy enhances Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells. BMC Cancer. 2014 Jul 30;14:551.(*通讯作者 ) IF: 3.3 6. Qi Xie, Jing Chen, Han Feng, Shengyi Peng, Ursula Adams, Yujie Bai, Li Huang, Ji Li, Junjian Huang, Songshu Meng*, Zengqiang Yuan*. YAP/TEAD-mediated transcription regulates the cellular senescence. Cancer research, 2013 Jun 15;73(12):3615-24. (*通讯作者 ) IF: 9.2 7. Songshu Meng*, Jiansheng Xu, Yantao Wu, Chan Ding*. Targeting autophagy to enhance oncolytic virus-based cancer therapy. Expert Opin Biol Therapy. 2013 Jun;13(6):863-73.(*通讯作者) IF: 3.6 8. Songshu Meng*, Zhizhi Zhou, Fei Chen, Xiangang Kong, Huairan Liu, Ke Jiang, Wenbo Liu, Maozhi Hu, Xiaorong Zhang, Chan Ding* , Yantao Wu*. Newcastle disease virus induces apoptosis in cisplatin-resistant human lung adenocarcinoma A549 cells in vitro and in vivo. Cancer Lett. 317(1):56-64,2012. (*通讯作者) IF: 4.2 9. Songshu Meng*, Miao Zhang, Wenyan Pan, Zhongliang Li, Deborah H. Anderson, Shengping Zhang, Baoxue Ge, Chuangui Wang*. Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation. Int J Biochem Cell Biol. 2012; 44(5):748-758. (*通讯作者) IF: 4.1 10. Chunchun Meng,Zhizhi Zhou,Ke Jiang,Shengqing Yu,Lijun Jia, Yantao Wu,Yanqing Liu,Songshu Meng*,Chan Ding*. Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication. Arch Virol. 2012;157(6):1011-1018(*通讯作者) IF: 2.0 11. Songshu Meng*, Ke Jiang, Xiaorong Zhang, Miao Zhang, Zhizhi Zhou, Maozhi Hu, Rui Yang, Chenli Sun,Yantao Wu*. Avian reovirus triggers autophagy in primary chicken fibroblast cells and Vero cells to promote virus production. Arch Virol. 2012;157 (4):661-668(*通讯作者) IF: 2.0 12. Yantao Wu, Xiaorong Zhang, Xiaobo Wang, Li Wang, Shunlin Hu, Xiufan Liu, Songshu Meng*. Apoptin Enhances the Oncolytic Properties of Newcastle Disease Virus. Intervirology. 2012; 55 (4):276-286(*通讯作者) IF: 1.8 13.Meng S, Gui Q, Xu Q, Lu K, Jiao X, Fan J, Ge B, Ke Y, Zhang S, Wu J, Wang C. Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation. J Mol Cell Biol. 2010 Aug; 2(4):223-30. (第一作者)IF:13.4

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