2002-2003年 遗传学硕士 英国伯明翰大学 2003-2007年 生物学博士 英国伯明翰大学

2013.9 -- 至今 大连医科大学肿瘤中心 课题组长/教授 2007.7 -- 2013.08 英国利物浦大学转化医学院 博士后

1. Lu Xu, Yang Zhang, Kang Tian, Xi Chen, Rongxin Zhang, Xindi Mu,Yueguang Wu, Duchuang Wang,Shanshan Wang, Fang Li, Taishu Wang, Jinrui Zhang, Shuyan Liu, Yingqiu Zhang, Caixia Tu*and Han Liu*. Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects. Journal of Experimental & Clinical Cancer Research. (2018) 37:261. *通讯作者(IF=6.217) 2. Wang T, Wang D, Zhang Y, Zhang J, Sun X, Wu Y, Wang S, Zhang Y, Xu L, Kong Q, Gao Y, Wu Y, Liu F, Liu S, Zhang Y, Lei T, Liu H*. Dynasore-induced potent ubiquitylation of the exon 19 deletion mutant of epidermal growth factor receptor suppresses cell growth and migration in non-small cell lung cancer. Int J Biochem Cell Biol. 2018 Sep 28;105:1-12. *通讯作者(IF=3.247) 3.Taishu Wang1, Jinrui Zhang1, Shanshan Wang1, Xiuna Sun, Duchuang Wang, Yurou Gao, Yang Zhang ,Lu Xu , Yue Wu, Yueguang Wu , Fang Liu , Xiuxiu Liu , Shuyan Liu, Yingqiu Zhang , Yang Wang , Lijuan Zou* and Han Liu*.The exon 19-deleted EGFR undergoes ubiquitylation-mediated endocytic degradation via dynamin activitydependent and -independent mechanisms. Cell Communication and Signaling. (2018) 16:40. *通讯作者(IF=5.324) 4. Wang M, Zhang Y, Wang T, Zhang J, Zhou Z, Sun Y, Wang S, Shi Y, Luan X, Zhang Y, Wang Y, Wang Y, Zou Z, Kang L, Liu H.The USP7 Inhibitor P5091 Induces Cell Death in Ovarian Cancers with Different P53 Status.Bio Cell Physiol chem. 2017 Oct 19;43(5):1755-1766. *通讯作者(IF = 5.1034) 5.Yingqiu Zhang 1, Jinrui Zhang 1, Congcong Liu, Sha Du , Lu Feng , Xuelin Luan ,Yayun Zhang , Yulin Shi , TaishuWang , YueWu ,Wei Cheng , Songshu Meng ,Man Li *, Han Liu **. Neratinib induces ErbB2 ubiquitylation and endocytic degradation via HSP90 dissociation in breast cancer cells.Cancer Lett. 2016 Nov 28;382(2):176-185. *通讯作者(IF = 5.992) 6. Zhang ZF, Feng XS, Chen H, Duan ZJ, Wang LX, Yang D, Liu PX, Zhang QP, Jin YL, Sun ZG, Liu H. Prognostic significance of synergistic hexokinase-2 and beta2-adrenergic receptor expression in human hepatocelluar carcinoma after curative resection. BMC Gastroenterol. 2016 Jun 3;16(1):57. (IF = 2.101) 7. Kang Tian, Weiliang Zhong, Xifu Zheng, Jinrui Zhang, Pixu Liu, Weiguo Zhang *, Han Liu*. Neuroleukin/Autocrine Motility Factor Receptor Pathway Promotes Proliferation of Articular Chondrocytes through Activation of AKT and Smad2/3. Scientific Reports,2015 Oct 13;5:15101. *通讯作者(IF=5.228) 8. Khan MN, Wang B, Wei J, Zhang Y, Li Q, Luan X, Cheng JW, Gordon JR, Li F*, Liu H*.CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis. Oncotarget. 2015 Aug 28;6(25):21315-27. doi: 10.18632/oncotarget.4066. *通讯作者(IF = 5.008) 9. Liu H, Urbé S, and Clague MJ. Regulation of endocytic trafficking and signaling by deubiquitylating enzymes. In Vesicle Trafficking in Cancer. 2013 pp 245-259. Edited by Yarden Y and Tarcic G. Springer science. (book chapter) 10. Hayes SD*, Liu H*, MacDonald E, Sanderson CM, Coulson JM, Clague MJ, Urbé S.Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. J Biol Chem. 2012. 287(51):43007-18. *并列第一作者 (IF = 4.651) 11. Clague MJ, Liu H, Urbé S. Governance of endocytic trafficking and signaling by reversible ubiquitylation. Dev Cell. 2012. 23(3):457-67. (IF = 12.861) Liu H, Urbé S, and Clague MJ. Selective protein degradation in cell signalling. Semin Cell Dev Biol. 2012. 509-14. (IF = 6.202) 12. Urbé S*, Liu H*, Hayes SD, Heride C, Rigden DJ, Clague MJ. Systematic survey of deubiquitinase localisation identifies USP21 as a regulator of centrosome and microtubule associated functions. Mol Biol Cell. 2012. 23(6):1095-103. *并列第一作者 (IF = 4.604)