教育背景
2005年毕业于大连医科大学检验医学院,获检验诊断学硕士学位;2014年毕业于大连医科大学基础医学院,获生物化学与分子生物学博士学位
工作经历
项目课题经历
1. N-糖基化修饰对CD82调控人结肠癌转移机制的研究(No.81602546),主持人,国家自然科学基金青年项目,2017.1-2019.12。
2.肿瘤转移抑制因子CD82细胞外小环结构域抑制肿瘤细胞迁移机制的研究(No.81472716),参与人,国家自然科学基金项目,2015.1-2018.12。
3.神经节苷脂GM3对乳腺癌淋巴道转移的影响及机制探讨,主持人,辽宁省科技厅自然科学基金项目
论文、成果、著作等
1. Functional role of glycosphingolipids in contact inhibition of growth in a human mammary epithelial cell line, FEBS Lett.2017;591: 1918-1928.(IF=3.623);
2. Ganglioside GM3 Inhibits Hepatoma Cell Motility via Down-Regulating Activity of EGFR and PI3K/AKT Signaling Pathway, Journal of Cellular Biochemistry. 2013; 114:1616–1624.(IF=3.062);
3. The cell adhesion molecule L1 regulates the expression of FGF21 and enhances neurite outgrowth, Brain Research. 2013; 1530: 13-21.(IF=2.879);
4. Ganglioside GM3 promotes HGFstimulated motility of murine hepatomacell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/ Akt-mediated migration signaling. Mol Cell Biochem. 2013; 382:83-92.(IF=2.329);
5. Phosphorylation of cMet tyrosine residues in murine ascitic hepatic cancer cell lines with different lymph node metastatic potentials, Mol Medicine Reports. 2013; 8: 655-661.(IF=1.17).
6. Synergistic inhibition of cell migration by tetraspanin CD82 andgangliosides occurs via the EGFR or cMet-activated Pl3K/Aktsignalling pathway, Int J Biochem Cell. 2013; 45: 2349-2358.(IF=4.152);
7. Cell recognition molecule L1 promotes embryonic stem cell differentiation through the regulation of cell surface glycosylation, BBRC. 2013; 440: 405–412.(SCI,IF=2.406)
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