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李镇

领域:生物产业 学校:大连医科大学职称:副教授

1. 多功能纳米材料和智能化纳米载体的设计与合成; 2. 肿瘤微环境敏感的纳米靶向递药系统的研究; 3. 缓控释固体制剂的研发。...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

2005-2008年,沈阳药科大学,获得药剂学硕士学位,师从丁平田教授,同年来到大连医科大学药学院药剂教研室工作。2011~2014年,沈阳药科大学,获药剂学博士学位,师从陈大为教授

工作经历

项目课题经历

国家自然科学基金项目,适配体修饰可触发释药的聚合物纳米靶向给药系统的构建及其机制研究(81302713),2014.1-2016.12,项目负责人。

论文、成果、著作等

[1] Li Z*, Chen Q, Qi Y, Liu Z, Hao T, Sun X, Qiao M, Ma X, Xu T, Zhao X, Yang C*, Chen D*. Rational Design of Multifunctional Polymeric Nanoparticles Based on Poly(l-histidine) and d-α-Vitamin E Succinate for Reversing Tumor Multidrug Resistance[J]. Biomacromolecules. 2018;19(7):2595-2609.(通讯作者) [2] Deng C, Hao T, Li Z*, Fan Q*. Physicochemical Properties that Determine Cellular Transport of Nanocarriers In Vitro and In Vivo[J]. Current Organic Chemistry. 2016; 20(17):1835-1848.(通讯作者) [3] Yu X, Tang C, Xiong S, Yuan Q, Gu Z, Li Z*, Hu Y*. Modification of collagen for biomedical applications: a review of physical and chemical methods. Current Organic Chemistry. 2016;20(17):1797-1812.(通讯作者) [4] Hao T, Chen D, Liu K, Qi Y, Tian Y, Sun P, Liu Y, Li Z*. Micelles of d-α-Tocopheryl Polyethylene Glycol 2000 Succinate (TPGS 2K) for Doxorubicin Delivery with Reversal of Multidrug Resistance[J]. ACS Appl. Mater. Interfaces. 2015;7(32):18064-75.(通讯作者) [5] Li Z, Qiu L, Chen Q, Hao T, Qiao M, Zhao H, Zhang J, Hu H, Zhao X, Chen D, Mei L. pH-sensitive nanoparticles of poly(l-histidine)-poly(lactide-co-glycolide)- tocopheryl polyethylene glycol succinate for anti-tumor drug delivery[J]. Acta Biomater. 2015;11:137-50. [6] Li Z, Liu K, Sun P, Mei L, Hao T, Tian Y, Tang Z, Li L, Chen D. Poly(D, L-lactide-co-glycolide)/montmorillonite nanoparticles for improved oral delivery of exemestane[J]. J Microencapsul. 2013;30(5):432-40. [7] Li Z, Hao T, Ding P, Mei L, Gao D, Liu K, Tian Y, Li L, Tian G. Effect of pH, Vehicles and Chemical Enhancers on the Skin Permeation of Loratadine[J]. Lat. Am. J. Pharm. 2011;30(3): 534-39. [8] Qiu L, Li Z, Qiao M, Long M, Wang M, Zhang X, Tian C, Chen D. Self-assembled pH-responsive hyaluronic acid-g-poly((L)-histidine) copolymer micelles for targeted intracellular delivery of doxorubicin[J]. Acta Biomater. 2014;10(5):2024-35. [9] Qiu L, Qiao M, Chen Q, Tian C, Long M, Wang M, Li Z, Hu W, Li G, Cheng L, Cheng L, Hu H, Zhao X, Chen D. Enhanced effect of pH-sensitive mixed copolymer micelles for overcoming multidrug resistance of doxorubicin[J]. Biomaterials. 2014;35(37):9877-87. [10] 李镇, 郝堂娜, 陈东, 丁平田. 羟丙基-β-环糊精对兰索拉唑的增溶作用及其包合物的制备[J]. 沈阳药科大学学报, 2009;26(3): 165-69.

专利、著作版权等

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