1988年毕业于中国医科大学临床医疗本科，1988-1991年在大连医科大学获得药理学硕士学位，留校工作至今。2001年获得生物化学专业博士学位

1）丹酚酸B 激活Nrf2/ARE 通路在对乙酰氨基酚肝损伤中的保护机制研究。国家自然基金（2012-2015.12, 进行中） 2）鼠尾草酸调控miR-34a/SIRT1-p66shc信号通路抗酒精性肝损伤的分子机制研究。国家自然基金（81473266，2015-2018.12, 进行中） 3）p66shc在肝纤维化发病中的作用及lnRNA-Mica12/mir-203-3p对其调控研究。国家自然基金（2018-2021.12）

1.Liu L, Yao J, Li Z, Zu G, Feng D, Li Y, Qasim W, Zhang S, Li T, Zeng H, Tian X.miR-381-3p knockdown improves intestinal epithelial proliferation and barrier function after intestinal ischemia/reperfusion injury by targeting nurr1.Cell Death Dis. 2018 Mar 14;9(3):411. （correspondence author，IF: 5.965） 2. Zhao H, Wang Z, Tang F, Zhao Y, Feng D, Li Y, Hu Y, Wang C, Zhou J, Tian X, Yao J.Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis.Pharmacol Res. 2018 Feb;128:327-337.（correspondence author，IF: 4.480） 3. Li Z, Wang G, Feng D, Zu G, Li Y, Shi X, Zhao Y, Jing H, Ning S, Le W, Yao J, Tian X.Targeting the miR-665-3p-ATG4B-autophagy axis relieves inflammation and apoptosis in intestinal ischemia/reperfusion.Cell Death Dis. 2018 May 1;9(5):483.（correspondence author，IF: 5.965） 4.Zhang S, Wang Z, Zhu J, Xu T, Zhao Y, Zhao H, Tang F, Li Z, Zhou J, Gao D, Tian X, Yao J.Carnosic Acid Alleviates BDL-Induced Liver Fibrosis through miR-29b-3p-Mediated Inhibition of the High-Mobility Group Box 1/Toll-Like Receptor 4 Signaling Pathway in Rats. Front Pharmacol. 2018 Jan 19;8:976.（correspondence author，IF:4.400） 5.Shi X, Zhao Y, Ding C, Wang Z, Ji A, Li Z, Feng D, Li Y, Gao D, Zhou J, Tian X, Yao J.Salvianolic acid A alleviates chronic ethanol-induced liver injury via promotion of β-catenin nuclear accumulation by restoring SIRT1 in rats.Toxicol Appl Pharmacol. 2018 Jul 1;350:21-31.（correspondence author，IF:3.791） 6. Zhao Y, Shi X, Ding C, Feng D, Li Y, Hu Y, Wang L, Gao D, Tian X, Yao J.Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPK alpha 1/SIRT1 pathway.Toxicol Appl Pharmacol. 2018 Jan 15;339:172-180.（correspondence author，IF:3.791） 7.Zhang N, Hu Y, Ding C, Zeng W, Shan W, Fan H, Zhao Y, Shi X, Gao L, Xu T, Wang R, Gao D, Yao J.Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats.Toxicol Lett. 2017 Feb 5;267:1-10.（correspondence author，IF:3.858） 8.P66shc promotes epithelial-to-mesenchymal transition in hepatic fibrosis.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY .2016 ; 31 : 398 - 398（IF：3.452）(SCI) 9.Shan W, Gao L, Zeng W, Hu Y, Wang G, Li M, Zhou J, Ma X, Tian X, Yao J.Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease.Cell Death Dis. 2015 Jul 23;6:e1833..(correspondence author，IF:5.378) 10.Wang G, Yao J, Li Z, Zu G, Feng D, Shan W, Li Y, Hu Y, Zhao Y, Tian X.miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling.Antioxid Redox Signal. 2016 Jun 10;24(17):961-73..(IF:6.337) 11.Gao L, Shan W, Zeng W, Hu Y, Wang G, Tian X, Zhang N, Shi X, Zhao Y, Ding C, Zhang F, Liu K, Yao J.Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1/ChREBP and SIRT1/p66shc pathways in rats.Mol Nutr Food Res. 2016 Sep;60(9):1902-11.(correspondence author，IF:4.323) 12.Ding C, Zhao Y, Shi X, Zhang N, Zu G, Li Z, Zhou J, Gao D, Lv L, Tian X, Yao J.New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.Sci Rep. 2016 Jun 27;6:28734.(correspondence author，IF:4.259) 13.Zeng W, Shan W, Gao L, Gao D, Hu Y, Wang G, Zhang N, Li Z, Tian X, Xu W, Peng J, Ma X, Yao J.Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease.Sci Rep. 2015 Nov 3;5:16013. (correspondence author，IF:5.228) 14.Fan Z, Yao J, Li Y, Hu X, Shao H, Tian X.Anti-inflammatory and antioxidant effects of curcumin on acute lung injury in a rodent model of intestinal ischemia reperfusion by inhibiting the pathway of NF-Kb.Int J Clin Exp Pathol. 2015 Apr 1;8(4):3451-9.(correspondence author，IF:1.706) 15.Hu Y, Zhang N, Fan Q, Lin M, Zhang C, Fan G, Zhai X, Zhang F, Chen Z, Yao J.Protective efficacy of carnosic acid against hydrogen peroxide induced oxidative injury in HepG2 cells through the SIRT1 pathway.Can J Physiol Pharmacol. 2015 Aug;93(8):625-31.(correspondence author，IF:1.822) 16. Lin M, Zhai X, Wang G, Tian X, Gao D, Shi L, Wu H, Fan Q, Peng J, Liu K, Yao J.Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways.J Pharmacol Sci. 2015 Feb;127(2):203-10.(correspondence author，IF:2.415) 17. 17.Yan H, Jihong Y, Feng Z, Xiaomei X, Xiaohan Z, Guangzhi W, Zhenhai M, Dongyan G, Xiaochi M, Qing F, Kexin L, Xiaofeng T.Sirtuin 1-Mediated Inhibition of p66shc Expression Alleviates Liver Ischemia/Reperfusion Injury.Crit Care Med. 2014 May;42(5):e373-81.(correspondence author，IF:6.312) 18.Wang G, Chen Z, Zhang F, Jing H, Xu W, Ning S, Li Z, Liu K, Yao J, Tian X.Blockade of PKC beta protects against remote organ injury induced by intestinal ischemia and reperfusion via a p66shc-mediated mitochondrial apoptotic pathway.Apoptosis. 2014 Sep;19(9):1342-53.(correspondence author，IF:3.833) 19.Li M, Lu Y, Hu Y, Zhai X, Xu W, Jing H, Tian X, Lin Y, Gao D, Yao J.Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats.Toxicol Lett. 2014 Jul 15;228(2):67-74.(correspondence author，IF:3.858) 20.Zhai X, Lin M, Zhang F, Hu Y, Xu X, Li Y, Liu K, Ma X, Tian X, Yao J.Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells.Mol Nutr Food Res. 2013 Feb;57(2):249-59.(correspondence author，IF:4.909) 21.Selective inhibition of protein kinase C beta(2) attenuates the adaptor P66(Shc)-mediated intestinal ischemia-reperfusion injury.Cell Death Dis. 2014 Apr 10;5:e1164. (correspondence author，IF:5.014) 22.Xu X, Hu Y, Zhai X, Lin M, Chen Z, Tian X, Zhang F, Gao D, Ma X, Lv L, Yao J.Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice.Toxicol Appl Pharmacol. 2013 Nov 15;273(1):68-76.(correspondence author，IF:3.791)

研究成果申请国家发明专利三项，授权1项。