教育背景
1986年毕业于中国医科大学医疗系(英文医疗专业)2005年至2008年在日本熊本大学分子医学药学研究部攻读生命科学(专业)博士学位
工作经历
项目课题经历
1、 SPINK1/Spink3在急性胰腺炎早期发病产生自噬作用机制的探索和疾病干预
2、 SPINK1/Spink3在结直肠癌肿瘤发病中自噬机制的探索及相关药物对肿瘤的控制
论文、成果、著作等
1. Hu N, Shen Y, Liu F, Wu J, Yuan F, Tian L, Wu B, Chen G, Zhang J, Wang J. * Morphological and immunobiochemical analysis of the liver in L-arginine induced experimental chronic pancreatitis. Pancreatology. 2017;17(2):247-254. (SCI IF:2.74)
2. Zhang J, Wang DM, Hu N,Wang Q, Yu S, Wang J. * The construction and proliferative effects of a lentiviral vector capable of stably overexpressing SPINK1 gene in human pancreatic cancer AsPC-1 cell line.Tumor Biol. 2016;37(5):5847-5855. (SCI IF:3.6)
3. Sun Y, Xing G, Bai J, Tang Z, Wang N, Gao C, Wang J. * A new mouse model of chronic pancreatitis in C57BL/6J strain that mimics the human pathology. Pancreas. 2014;43(1):148-150. (SCI IF:3.2)
4. Ozaki N, Fukuchi Y, Tomiyoshi SR, Uehara H, Ida S, Wang J, Araki K, Sibilia M, Baba H, Yamamura K, Ohmuraya M. Autophagy regulation in pancreatic acinar cells is independent of epidermal growth factor receptor signaling. Biochem Biophys Res Commun. 2014 ; 28:446(1): 224-230. (SCI IF:2.29)
5. Sakata K, Ohmuraya M, Araki K, Suzuki C, Ida S, Hashimoto D, Wang J, Uchiyama Y, Baba H, Yamamura K. Generation and analysis of serine protease inhibitor kazal type 3-cre driver mice.Exp Anim. 2014;63(1):45-53. (SCI IF:0.96)
6. Zhenghua L, Gang Zhao G, Jingling Shen JL, Kimi Araki K, Wang J, and Ken- ichi Yamamura. Enhanced expression of human cDNA by phosphoglycerate kinase promoter-puromycin cassette in the mouse transthyretin locus.Transgenic Research. 2011; 20(1):191-200. ( SCI IF:2.54)
7.Wang J, * Ohmuraya M, Yamamura KI. Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression. Laboratory Investigation. 2010. 90:654-664. (SCI IF:4.45)
8. Ozaki N, Ohmuraya M, Hirota M, Ida S, Wang J, Takamori H, Higashiyama S, Baba H, Yamamura KI. Serine protease inhibitor Kazal type 1 promotes proliferation of pancreatic cancer cells through the epidermal growth factor receptor. Molecular Cancer Research 2009 Sep:7(9):1572-1581.(SCI IF: 4.76)。
9. Hashimoto D, Ohmuraya M, Hirota M, Wang J, Baba H, Yamamura KI. Effect of low-molecular weight trypsin inhibitor, nafamostat mesilate, on trypsin activity using the pancreatic acinar cells.,Pancreas 2009 Jul;38(5):595-597. (SCI IF: 2.1)。
10. Wang J, * Ohmuraya M, Hirota M, Barba H, Zhao G, Araki K, Yamamura KI. Expression pattern of serine protease inhibitor kazal type 3 (Spink3) during mouse embryonic development. Histochemistry and Cell Biology, 130(2):387-397, 2008,. (SCI IF: 3.3)。
11. Wang J, * Shaw JL, Mullen CA. Down-regulation of antihost alloreactivity after bone marrow transplant permits relapse of hematological malignancy. Cancer Research 62:208-212,2002(SCI IF: 8.3)。
专利、著作版权等
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