首页 > 专家库
李炜玲

领域:生物产业 学校:大连医科大学职称:教授

主要致力于肿瘤形成和耐药性机制的研究。研究方向包括:磷酸化酶在肿瘤发生发展过程中作用;DNA修复蛋白的表达在顺铂耐药过程中的作用;肿瘤免疫微环境对肿瘤生成的调节作用;代谢药物对肿瘤发生,发展的影响。在细胞分子肿瘤生物学、生物化学、分子生物学等学科有较深的造诣,得到了国际同行的认可。...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

2007年9月——2011年7月 理学博士 爱丁堡大学 2004年9月——2007年7月 理学硕士 大连医科大学 1999年9年——2004年7月 医学学士 大连医科大学

工作经历

2017年12月——至今 教授 大连医科大学 2012年3月 ——2017年12月 副教授 大连医科大学

项目课题经历

1.辽宁省科技厅自然科学基金计划重点项目,“剪切体干扰性药物E7107抑制U2AF1突变MDS细胞生长及机制研究”,2017/5-2019/4,项目主持人。 2. 国家自然科学基金青年项目,“新ERCC1剪切变异体在卵巢癌化疗耐药和肿瘤发生过程中的作用及其机制研究”,2013-2015, 项目主持人。 3. 留学回国人员科技活动择优资助项目(启动类),“ERCC1表达水平变化对卵巢癌耐药的影响”,2013-2014, 项目主持人。 4. 教育部留学回国人员科研启动基金, “新ERCC1剪切体表达水平变化ᠦ୔

论文、成果、著作等

1. Jia Liu; Guoqiang Jiang; Ping Mao; Jing Zhang; Lin Zhang; Likun Liu; Jia Wang; Lawrence Owusu;Baoyin Ren;Yawei Tang;Weiling Li*. Down-regulation of GADD45A enhances chemosensitivity in melanoma. scientific report.2018,8: 4111-4122. 2. Liu, Jia; Zhang, Lin; Mao, Ping; Jiang, Guoqiang; Liu, Likun; Wang, Jing; Yang, Wei; Owusu, Lawrence;Li,Weiling*. Functional characterization of a novel transcript of ERCC1 in chemotherapy resistance of ovarian cancer. ONCOTARGET. 2017. 8(49): 85759-85771 3. Zhang, Lin; Ren, Baoyin; Zhang, Jing; Liu, Likun; Liu, Jia; Jiang, Guoqiang; Li, Man; Ding, Yuejia;Li,Weiling*. Anti-tumor effect of Scutellaria barbata D. Don extracts on ovarian cancer and its phytochemicals characterisation. JOURNAL OF ETHNOPHARMACOLOGY.2017,206: 184-192. 4. Jiang ,Guoqiang#; Liu,Jia#; Ren,Baoyin; Zhang,Lin; Owusu; Liu,Likun; Zhang,Jing; Tang,Y; Li,Weiling*. Anti-tumor and chemosensitization effects of Cryptotanshinone extracted from Salvia miltiorrhiza Bge. on ovarian cancer cells in vitro. Journal of Ethnopharmacology. 2017, 205: 33~40. 5.Jiang G, Liu J, Ren B, Tang Y, Owusu L, Li M, Zhang J, Liu L, Li W*. Anti-tumor effects of osthole on ovarian cancer cells in vitro.Journal of ethnopharmacology. 2016, 193:368-376.2. 6.Zhang L, Zhang J, Qi B, Jiang G, Liu J, Zhang P, Ma Y, Li W*. The anti-tumor effect and bioactive phytochemicals of Hedyotis diffusa willd on ovarian cancer cells. J Ethnopharmacol. 2016, 192:132-139. 7.Liu J, Bai J, Jiang G, Li X, Wang J, Wu D, Owusu L, Zhang E, Li W*. Anti-Tumor Effect of Pinus massoniana Bark Proanthocyanidins on Ovarian Cancer through Induction of Cell Apoptosis and Inhibition of Cell Migration. PLoS One. 2015;10(11):e0142157. 8.Owusu L, Wang B, Du Y, Li W*, Xin Y*. The quantum of initial transformed cells potentially modulates the type of local inflammation mechanism elicited by surrounding normal epithelial tissues and systemic immune pattern for tumor arrest or progression. Journal of Cancer. 2015;1;6(2):128-38. 9.Chen Y, Liu ZJ, Liu J, Liu LK, Zhang ES, Li WL*. Inhibition of metastasis and invasion of ovarian cancer cells by crude polysaccharides from rosa roxburghii tratt in vitro. Asian Pac J Cancer Prev. 2014;15(23):10351-4. 10. Li, Weiling, Li, Ye, Zhao, Yuwan, Yuan, Jieli, Mao, Weifeng. INHIBITION EFFECTS OF SCORPION VENOM EXTRACTS (BUTHUS MATENSII KARSCH) ON THE GROWTH OF HUMAN BREAST CANCER MCF-7 CELLS. AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES. 2014 ; 11 ( 5): 105 -110 11. Li, Weiling; Xin, Yi; Chen, Yang; Li, Xinli; Zhang, Cuili; Bai, Jing; Yuan, Jieli .The anti-proliferative effects and mechanisms of low molecular weight scorpion BmK venom peptides on human hepatoma and cervical carcinoma cells in vitro . ONCOLOGY LETTERS. 2014 ; 8 ( 4): 1581 - 1584 12. Li, W. *; Wu, D.; Wei, B.; Wang, S.; Sun, H. X.; Li, X. L.; Zhang, F.; Zhang, C. L.; Xin, Y. ANTI-TUMOR EFFECT OF CACTUS POLYSACCHARIDES ON LUNG SQUAMOUS CARCINOMA CELLS (SK-MES-1) .AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES , 2014, ; 11 ( 5): 99 - 104. 13. Li W, Melton DW*. 2012. Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance. Oncogene. 10;31(19):2412-2422. 14. Li W, Song L, Ritchie AM, Melton DW*. 2012. Increased levels of DUSP6 phosphatase stimulate tumourigenesis in a molecularly distinct melanoma subtype. Pigment Cell Melanoma Res. 25(2):188-199.

专利、著作版权等

声明:本站专家信息来源于各高校官网。