2003年09月——2008年10月应用化学博士 大连理工大学 1999年09月——2003年07月应用化学学士 中国矿业大学

1. 2013/12-至今，大连医科大学，生物技术系，副教授 1.2012/5-2013/12，大连医科大学，生物技术系，讲师 2.2008/12-2012/5，南开大学，药学院，讲师

非小细胞肺癌表面高表达糖蛋白的代谢标记及应用研究（81302793），国家自然基金项目 代表性论文（近5年）：

1. Weng ZM, Ge GB, Dou TY, Wang P, Liu PK, Tian XH, Qiao N, Yu Y, Zou LW, Zhou Q, Zhang WD, Hou J*(侯洁). Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2. Bioorg Chem. (IF = 3.231) 2018; 77: 320-329. 2. Weng ZM, Wang P, Ge GB, Dai ZR, Wu DC, Zou LW, Dou TY, Zhang TY, Yang L, Hou J*(侯洁). Structure-activity relationships of flavonoids as natural inhibitors against E. coli β-glucuronidase. Food Chem Toxicol. (IF = 3.778) 2017; 109:975-983. 3. Feng L1, Liu ZM1, Hou J1, Lv X, Ning J, Ge GB, Cui JN, Yang L. A highly selective fluorescent ESIPT probe for the detection of human carboxylesterase 2 and its biological applications. Biosensors & Bioelectronics (IF = 7.476), 2015.03, 65: 9-15. 2. Ning J1, Hou J1, Wang P, Wu JJ, Dai ZR, Zou,LW, Li W, Ge GB, Ma XC, Yang L. Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human. Xenobiotica (IF = 1.723)，2015，45(11)：954-960。 (3) Li YG1, Hou J1, Li SY, Lv X, Ning J, Wang P, Liu ZM, Ge GB, Ren JY, Yang L(*)，Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase2，Fitoterapia (IF = 2.345), 2015, 101: 99-106. (4) Liu ZM1, Feng L1, Hou J1, Lv X, Ning J, Ge GB, Wang KW, Cui JN, Yang L. A ratiometric fluorescent sensor for highly selective detection of human carboxylesterase 2 and its application in living cells, Sensors and Actuators B: Chemical (IF = 4.097), 2014, 205: 151-157. (5) Yang XB1, Hou J1, Liu D, Deng S, Wang ZB, Kuang HX, Wang CY, Yao JH, Liu KX, Ma XC. Biotransformation of isoimperatorin by Cunninghamella blakesleana AS 3.970，Journal of Molecular Catalysis B: Enzymatic (IF = 2.823), 2013, 88: 1-6. (6) Lv X, Wang DD, Feng L, Wang P, Zou LW, Hao DC, Hou J*, Cui JN, Ge GB, Yang L. A highly selective marker reaction for measuring the activity of human carboxylesterase1 in complex biological samples, RSC advances (IF = 3.289), 2015, 6: 4302-4309. (7) Hou J*, Shi Q, Cao MR, Pan PW, Ge GB, Fan XR, Bai G, Xin Y. A novel approach for fluorescent visualization of glycyrrhetic acid on a cell with a quantum dot. Biochemistry (Mosc) (IF = 1.303), 2014, 79(1): 25-30. (8) Wang DD, Zou LW, Jin Q, Hou J*, Ge GB*, Yang L, Recent progress in the discovery of natural inhibitors against human carboxylesterases, Fitoterapia, (IF=2.345) 2017, 117: 84-95. (9) 杨刚, 朱亮亮, 吕侠, 吴大畅, 夏杨柳, 马骁驰, 辛毅, 侯洁*, 双酚A葡萄糖醛酸苷的高效制备，高等学校化学学报, (IF = 0.929) 2014, 35(2): 314-318.