2004/9 - 2007/7，大连医科大学，生物化学与分子生物学，博士，导师：燕秋 1999/9 - 2002/7，大连医科大学，生物化学与分子生物学，硕士，导师：朱正美 1991/9 - 1996/7，大连医科大学，医学检验专业，学士

2002.7-今 大连医科大学生物化学与分子生物学教研室 讲师，副教授，教授 1996.8-1999.9 大连医科大学分析测试中心 助教

1.辽宁省自然科学基金项目，201602242，《EpCAM的N-糖基化修饰调节乳腺癌细胞上皮间质转化作用机制的研究》2016/6-2019/6，5万，在研，主持 2.国家自然科学基金面上项目，31670810，《生殖内分泌激素对多囊卵巢综合征（PCOS）蛋白质糖基化的调控及致病机制的研究》2016/1-2019/12，60万，在研, 参加 3. 国家科技部973课题项目，2012CB822103《肿瘤的糖化学生物学前沿问题--糖链对肿瘤细胞生物学行为的影响及机制研究》2012/1-2016/12，460ᠦ୔

1) Zhang, Dandan; Liu, Xue; Gao, Jiujiao; Sun, Yan; Liu, Tingjiao; Yan,Qiu; Yang, Xuesong ,The role of epithelial cell adhesion moleculeN-glycosylation on apoptosis in breast cancer cells , TUMOR BIOLOGY, 2017.3, 39(3): 1~8. (通讯作者) (IF=3.65) 2) Zheng Q; Zhang D; Yang YU; Cui X; Sun J; Liang C; Qin H; Yang X; Liu S;Yan Q. ,MicroRNA-200c impairs uterine receptivity formation by targeting FUT4 and α1,3-fucosylation., Cell Death Differ., 2017.12.1, 24(12): 2161~2172. (IF=8.3) 3) Gao, Shuhang; Sun, Yan; Liu, Xue; Zhang, Dandan; Yang, Xuesong ,EpCAM and COX-2 expression are positively correlated in human breast cancer ,MOLECU LAR MEDICINE REPORTS, 2017.6, 15(6): 3755~3760(通讯作者) (IF=1.532) 4) Jiujiao, Gao, Xue liu, Fan Yang, Tingjiao Liu, Qiu Yan, Xuesong Yang. By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis.Oncotarget. 2015 Sep 29;6(29):27187-98.(通讯作者) (IF=6.359) 5) Xuesong Yang，Shuai Liu, Qiu yan. Role of fucosyltransferase IV in epithelial-mesenchymal transition in breast cancer cells. Cell Death Dis. 2013 Jul 25;4:735. (通讯作者) （IF=5.117） 6) Jiujiao, Gao, Qiu Yan, Jiao Wang, Suai Liu, Xuesong Yang. Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by AP1-Dependent EpCAMExpression in MCF-7 Cells. J Cell Physiol. 2015 Apr;230(4):775-82. (通讯作者) （IF=3.874） 7) Xuesong Yang, Jiao Wang, Shuai Liu, Qiu Yan. HSF1 and Sp1 Regulate FUT4 Gene Expression and Cell Proliferation in Breast Cancer Cells. J Cell Biochem. 2014 Jan;115(1):168-78. (通讯作者) （IF=3.062） 8) Jiujiao, Gao, Qiu Yan, Suai Liu, Xuesong Yang. Knockdown of EpCAM enhances the chemosensitivity of breast cancer cells to 5-fluorouracil by downregulating the antiapoptotic factor Bcl-2. PLoS One. 2014 Jul 14;9(7):e102590. (通讯作者) （IF=3.534） 9) Xuesong Yang, Shuai Liu, Yuejian Liu, Jiwei Liu, Xiaoqi Wang, Tingjiao Liu, Qiu Yan. Overexpression of fucosyltransferase IV promotes A431 cell proliferation through the MAPK and PI3K/Akt signaling pathways. J cell physiol. 2010;225: 612–619. (第一作者) （IF=3.986） 10) Xuesong Yang, Yuejian Liu, Jiwei Liu, Xiaoqi Wang, Qiu Yan. Cyclophosphamide-induced apoptosis in A431 cells is inhibited by Fucosyltransferase IV. J cell Biochem. 2011 112(5):1376-83. (第一作者)（IF=3.122） 11) Xuesong Yang, Shuai Liu, Qiu Yan. Fucosyltrans¬ferase IV induces expression of MMP-12 stimulated by EGF via the ERK1/2, p38, NF-kB pathways in A431cells. Asian Pac J Cancer Prev. 2012;13(4):1657-62. (通讯作者) （IF=0.659） 12) Xuesong Yang, Zhenbo Zhang, Shuang Jia, Liu Yuejian, Wang Xiaoqi, Qiu Yan. Overexpression of fucosyltransferase IV in A431 cell line increases cell proliferation. Int J Biochem Cell Biol. 2007;39(9):1722-1730. (第一作者)（IF=4.24） 13) Xuesong Yang, Yan Dong, Jinyao Zhao, Huijun Sun, Yanjie Deng, Qiu Yan. Increased expression of human macrophage metalloelastase (MMP-12) isassociated with the invasion of endometrial adenocarcinoma. Pathol Res Pract. 2007;203(7):499-505. (第一作者)（IF=1.562） 14) Aziz F, Xuesong Yang , Xiaoqi Wang, Qiu Yan. Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study. 2015 Jul;141(7):1221-35..(IF=3.081) 15) Shuai Liu, Jiao Wang, Huming Qin, Xiaomei Yan, Xuesong Yang , Chang Liu, Qiu Yan. LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal-maternal interface.Cell Death Dis. 2014 Aug 28;5:e1396. （IF=5.117） 16) Aziz F, Xin Chen, Xuesong Yang , Qiu Yan. Prevalence and correlation with clinical diseases of Helicobacter pylori cagA and vacA genotype among gastric patients from Northeast China. Biomed Res Int. 2014;2014:142980. (IF=1.579) 17) Shuai Liu, Xuesong Yang, Jiao Wang , Jiwei Liu, Dongmei Zhang, Xiaoqi Wang, Qiu Yan .Differential expression of LeY and fucosyltransferase IV correlates with the receptivity of RL95-2 and HEC-1A human uterine epithelial cells. Cell Biol Int. 2012 May 1;36(5):469-74. （IF=1.635） 18) Liu Shuai, Yang Xuesong, Liu Yuejian, Wang Xiaoqi, Yan Qiu. sLeX / L-selectin mediates adhesion in vitro Implantation Model. Molecular and Cellular Biochemistry. 2011 350(1-2):185-92. （IF=2.388） 19) Hongyan Li, Shaoming Tong, Jiwei Liu, Han L, Xuesong Yang, Hong Hou, Qiu Yan, Xiaoqi Wang. Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation. Cell Mol Biol Lett. 2012 Jun;17(2):206-16. (IF=1.782) 20) Weijia Liu, Enxin Zhu, Ru Wang, Lihong Wang, Lu Gao, Xuesong Yang, Tingjiao Liu. Cyclin D1 gene polymorphism, A870G, is associated with an increased risk of salivary gland tumors in the Chinese population. Cancer Epidemiology. 2011;35(4):12-7 (IF=2.558) 21) 杨雪松；刘帅；燕秋. 人FUT4基因近端启动子结构的初步分析. 中国生物化学与分子生物学报,2012.28（4）：365-369. (第一作者)