1997年09月 - 2000年06月，理学博士 大连医科大学 1991年01月 - 1994年05月，理学硕士 美国 North Dakota State University 1984年09月 - 1987年07月，理学硕士 北京师范大学 1980年09月 - 1984年07月，理学学士 河南师范大学

2000年06月至今，教授 大连医科大学 2000年06月 - 2001年09月，博士后 美国 Colorado State University 1996年05月 - 2000年05月，副教授 大连医科大学 1994年05月 - 1996年04月，副研究员 美国 Colorado State University 1989年05月 - 1990年12月，研究助理 美国 North Dakota State University 1987年07月 - 1989年04月，助教、讲师 河南医科大学

1、国家自然科学基金 (81573469)：结核分枝杆菌GlmU乙酰基转移酶抑制剂的作用机制研究及抑菌效果评价 (2016.1. - 2019.12.，54.00 万)，排名1 2、大连医科大学首批 “英才工程” 优秀人才支持计划 (第二层次)，结核分枝杆菌细胞壁合成酶和细胞壁蛋白功能研究、2013/04 - 2016/03、排名1 3、国家重点基础研究发展计划、动物重要病原菌功能基因组与分子致病机理研究、课题3：病原菌表面多糖的结构与功能、2012/01 - 2016/12、排名2 4、高等学校博士学科ᠦ୔

1.Guoying Deng, Fei Zhang, Shufeng Yang, Jian Kang, Shanshan Sha, Yufang Ma.Mycobacterium tuberculosisRv0431, a mannosylated protein, enhanced the mycobacterial survival and modulated cytokines production of RAW 264.7 macrophages. Microbial Pathogenesis (1.888) 2016, 100: 285-292. 2.Liming Xu, Lei Qian, Jian Kang, Shanshan Sha, Xin Yi, Shen Lu, Yufang Ma. Down-regulation of N-acetylglucosamine-1-phosphatetransferase(WecA) enhanced the sensitivity of Mycobacterium smegmatisagainstrifampin. Journal of Applied Microbiology (2.156) 2016, 121: 966-972. 3.Qiulong Yan, Song Cui, Changming Chen, Shenghui Li, Shanshan Sha, Xianyao Wan, Yi Xin, Yufang Ma.Metagenomic analysis of sputum microbiome as a tool towards culture-independent pathogen detection of patients with ventilator-associated pneumonia. American Journal of Respiratory and Critical Care Medicine(13.118)2016, 195(5): 636-639.4.Xiaofeng Yao,Shanshan Sha, Yuexia Wang, Xiance Sun, Jun Cao, Jian Kang, Liping Jiang, Min Chen, Yufang Ma. Perfluorooctane sulfonate induces autophagy dependent apoptosis through Spinster 1-mediated lysosomal-mitochondrial axis and impaired mitophagy. Toxicological Sciences(3.88)2016, 153(1): 198-211.5.Xiaofeng Yao and Yufang Ma. Chapter 9. Organic pollutant perfluorooctane sulfonate-induced lysosomal membrane permeabilization blocks autophagy flux in human hepatoma cells. In: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Volume 9. Human Diseases and Autophagosome(1st edition) (Edited by Hayat MA).Academic Press(2016),ISBN 978-0128029367.pp176-184.6.Shanshan Sha, Xiaoxia Shi, Liming Xu, Jiabin Wen, Yi Xin and Yufang Ma.Viability, morphology and proteome of M. smegmatisMSMEG_0319 knockout strain.Proteomics(4.079) 2016, 16: 1090-1099. 7.Xiaoxia Shi,Shanshan Sha,Likun Liu, Xin Li, Yufang Ma. Amicrotiter plate assay for high-throughput screening of Mycobacterium tuberculosisdTDP-D-glucose-4,6-dehydratase inhibitors. Analytical Biochemistry (2.243) 2016, 498: 53-58. 8.JianjunLiu, Qiulong Yan, Fuwen Luo, Dong Shang, Dachang Wu, Haiquan Zhang, Xueqi Shang, Xiaoli Kang, Meyiah Abdo, Beibei Liu, YufangMaand Yi Xin.Acute cholecystitis associated with infection ofEnterobacteriaceaefrom gut microbiota. Clinical Microbiology and Infection (4.575)2015,21(9):851.e1-9. 9.Shufeng Yang, Fei Zhang, Jian Kang, Wenli Zhang, Guoying Deng, Yi Xin, Yufang Ma. Mycobacterium tuberculosisRv1096 protein: gene cloning, protein expression,and peptidoglycan deacetylase activity.BMC Microbiology (2.976)2014, 14:174. 10.Xiao-Feng Yao,Jun Cao, Li-Ming Xu, Xian-CeSun, Jian Kang, Guang Yang, Li-PingJiang, Cheng-Yan Geng, Chuan-Zhou Gao,Lai-Fu Zhong, Yu-Fang Ma. Perfluorooctane sulfonate blocked autophagy flux and induced lysosome membrane permeabilization in HepG2 cells. Food and Chemical Toxicology (2.61)2014, 67:96-104.11.Juanjuan Qiu, Yufang Ma,LawrenceOwusu, Tao Jiang,Yi Xin. Functional analysis ofserine acetyltransferasefrom Mycobacterium smegmatis.Journal of Basic Microbiology(1.822)2014, 54:670-677. 12.Liming Xu, Dongting Wu, Liang Liu, Qi Zheng, Yu Song, Li Ye, Shanshan Sha, Jian Kang, Yi Xin, Yufang Ma. Characterization of mycobacterial UDP-N-acetylglucosamine enolpyruvyle transferase (MurA). Research in Microbiology(2.828)2014, 165:91-101. 13.Huajun Li, Jya-Wei Cheng,Hui-Yuan Yu, Yi Xin, Li Tang and Yufang Ma. Effect of the antimicrobial peptide D-Nal-Pac-525 on the growth of Streptococcus mutansand its biofilm formation. Journal of Microbiology and Biotechnology (1.32),2013, 23(8):1070-1075.14.Jian Kang, Liming Xu, Shufeng Yang, Wendan Yu, Shuo Liu, Yi Xin and Yufang Ma. Effect of phosphoglucosamine mutase on biofilm formation and antimicrobial susceptibilities in M. smegmatis glmM gene knockdown strain. PLoS One (3.534), 2013, 8(4): e61589.15.Juanjuan Qiu, Daiqing Wang, Yufang Ma, Tao Jiang, Yi Xin.Identification and characterization of serine acetyltransferase encoded by the Mycobacterium tuberculosisRv2335 gene. InternationalJournalof MolecularMedicine (1.88), 2013, 31(5):1229-1233. 16.Sebabrata Mahapatra, Charles Piechota, Filipa Gil, Yufang Ma, Hairong Huang, MichaelS. Schermana, Victoria Jones, Martin S. Pavelka, Jr., Jose Moniz-Pereira, Madalena Pimentel,Michael R. McNeiland Dean C. Crick.Mycobacteriophage Ms6 LysA is a peptidoglycan amidase and a useful analytical tool.Applied and Environmental Microbiology (3.952)2013, 79:768-773. 17.Yan Zhou, Wendan Yu,Qi Zheng, Yi Xin and Yufang Ma. Identification of amino acids involved in catalytic processof M. tuberculosisGlmU acetyltransferase.GlycoconjugateJournal (1.882),2012, 29:297-303. 18.Shuang Li, Jian Kang, Wendan Yu, Yan Zhou, Wenli Zhang, Yi Xin, Yufang Ma. Identification of M. tuberculosis Rv3441c and M. smegmatisMSMEG_1556 and essentiality of M. smegmatis MSMEG_1556. PLoS One (3.73)2012, 7(8):e42769.19.Guang Yang, Shaopeng Wang, Laifu Zhong, Xu Dong, Wenli Zhang, Liping Jiang, Chengyan Geng, Xiance Sun, Xiaofang Liu, Min Chen and Yufang Ma.6-Gingerol induces apoptosis through lysosomal-mitochondrial axis in human hepatoma G2 cells. PhytotherapyResearch(2.068)2012, 26:1667-1673.20.Shanshan Sha, Yan Zhou, Yi Xin, Yufang Ma. Development of a colorimetric assay and kinetic analysis for Mycobacterium tuberculosis D-glucose-1-phosphate thymidylyltransferase.Journal of Biomolecular Screening(2.207)2012, 17(2):252-257.