1984年毕业于白求恩医科大学，获医学学士学位；1987年毕业于白求恩医科大学，获医学硕士学位；1994年毕业于白求恩医科大学，获医学博士学位。

1991年，在美国加州大学旧金山医学院从事教学和科研工作；2003年，在东北师范大学从事教学和科研工作；2009年，在吉林大学第二医院从事教学和科研工作；2013年，在大连医科大学从事教学和科研工作。

1.国家自然科学基金面上项目（课题号31471099）， 2015年-2018年，86万元人民币，主持人 2.973项目课题（课题号2012CB944702），2012年-2016年，210万元人民币，课题骨干 3.国家自然科学基金面上项目（课题号81173109），2011年-2014年，65万元人民币，主持人 4.973项目课题（课题号2009CB521908），330万元人民币，2009年-2014年，课题负责人

1Defective macrophage function in aquaporin-3 deficiency. Faseb J. 2011 Dec; 25(12):4233-9.5.7122Expression and function of aquaporins in peripheral nervous system. Acta Pharmacol Sin. 2011 Jun; 32(6):711-5. 1.9533CFTR chloride channel as a molecular target of anthraquinone compounds in herbal laxatives. Acta Pharmacol Sin.2011 Jun; 32(6):834-9.1.9534Pregnant phenotype in aquaporin 8-deficient mice. Acta Pharmacol Sin. 2011 Jun; 32(6):840-4. 1.9535Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways. Int J Oncol.2012 Apr; 40(4):1153-61. 2.6576Tanshinones Increase Fibrinolysis through Inhibition of Plasminogen Activator Inhibitor-1. CNS Neurosci Ther. 2012 May; 18(5):436-8.4.4587Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy. 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Pharmazie.2013,68(9):772-6.0.96220Increased expression levels of vitronectin in the maternal-fetal interface of placenta in early-onset severe preeclampsia. Mol Med Rep.2013, 7(1):53-8. 1.1721Prevalence of infarct and villous clumps, and the expression of α-smooth muscle actin in the placental basal plate in severe preeclampsia. Mol Med Rep.2013,8(4):1067-73. 1.1722Occurrence of multi-oocyte follicles in aquaporin 8-deficient mice. Reprod Biol Endocrinol. 2013, 11:88. 2.14423Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase/Akt signaling pathways. Arch Pharm Res. 2013, 36(10):1262-9. 1.53824Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway. Pharmazie. 2013, 68(9):755-62.0.96225Anoctamin 1 calcium-activated chloride channel downregulates estrogen production in mouse ovarian granulosa cells. Endocrinology.2014:en20132155. 4.71726Role of aquaporin 1 in fetal fluid homeostasis. J Matern Fetal Neonatal Med. 2014, 27(5):505-10. 1.51827Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice. Gut. 2014, 63(7):1120-9. 10.73228Identification of resveratrol oligomers as inhibitors of cystic fibrosis transmembrane 2014, 9(4):e94302. 3.73 conductance regulator by high-throughput screening of natural products from chinese medicinal plants. 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有嘧啶（硫）酮类化合物在制药中的应用发明专利。 1.ZL200510017135.X，2009年7月，发明专利，排名1