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领域:生物产业 学校:大连医科大学职称:教授

主要致力于血管性疾病相关分子机制研究,炎症与动脉粥样硬化及调控分子机制的研究。主要方向为MLCK调节平滑肌细胞骨架蛋白分子机制的研究;ROCK亚型调控平滑肌收缩及迁移的分子机制;HSP60与动脉粥样硬化及相关分子机制的研究;MicroRNA调控MLCK及平滑肌收缩机制的研究;重组人CXCR1/2拮抗剂G31P干预高脂血症和动脉粥样硬化发展过程及机制等。...

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教育背景

1984年业于大连医科大学临床医疗专业,获医学学士学位。1993年获生物化学与分子生物学硕士学位。1999年获生物化学与分子生物学专业博士学位

工作经历

项目课题经历

1. 主持国家自然科学基金面上项目:microRNAs在MLCK调控动脉粥样硬化血管重构中的作用及分子机制(31370800);2014-2017年;80万。 2. 主持国家自然科学基金面上项目:MLCK调节平滑肌细胞骨架蛋白分子机制的研究(31070719);2010-2012年;35万。 3. 主持国家自然科学基金面上项目:肌球蛋白轻链激酶非激酶活性调节平滑肌收缩的分子机制(30470394);2005-2007年;21万。 4. 参与(第2位) 国家自然科学基金青年项目:miRNA-92a对Rho激ᠦ୔

论文、成果、著作等

(1) Guangxin Lv, Hongmei Zhu, Cai Li, Jingyu Wang, Dandan Zhao, Shuyao Li, Le Ma, Guohua Sun, Fang Li, Ying Zhao*, Ying Gao*. Inhibition of IL-8-mediated endothelial adhesion, VSMCs proliferation and migration by siRNA-TMEM98 suggests TMEM98’s emerging role in Atherosclerosis. Oncotarget. 2017, 8 (50): 88043-88058. (2) Ying Zhao, ChenXu Zhang, XuGe Wei, Pei Li, Ying Cui, YuanHua Qin, MinLi Jin, XiaoQing Wei, Kazuhiro Kohama , Ying Gao*. Heat shock protein 60 stimulates the migration of vascular smooth muscle cells via Toll-like receptor 4 and ERK MAPK activation. Scientific Reports. Srep15352, 2015. (3) Ying Cui, YinWei Sun, HaiShuang Lin, WeiMin Su, Yan Fang, Ying Zhao, XiaoQing Wei, YuanHua Qin, Kazuhiro Kohama, Ying Gao*. Platelet-derived growth factor-BB induces matrix metalloproteinase-2 expression and rat vascular smooth muscle cell migration via ROCK and ERK/p38 MAPK pathways. Mol Cell Biochem, 393(1-2):255-263, 2014. (4) Ying Zhao, Miao Lv, HaiShuang Lin, Yan Hong, Ying Cui, XiaoQing Wei, YuanHua Qin, Kazuhiro Kohama, Ying Gao*. Rho-associated protein kinase isoforms stimulate proliferation of vascular smooth muscle cells through ERK and induction of cyclin D1 and PCNA. Biochem Biophys Res Commun. 432:488-493, 2013. (5) YuanHua Qin, FuShun Fan, Ying Zhao, Ying Cui, XiaoQing Wei, Kazuhiro Kohama, John Gordon, Fang Li* and Ying Gao*. Recombinant human CXCL8(3-72)K11R/G31P regulates smooth muscle cell proliferation and migration through blockage of IL-8 receptor. IUBMB Life. 65(1):67-75, 2013. (6) Ying Zhao, Miao Lv, HaiShuang Lin, Yan Hong, FuChun Yang, YunLiang Sun, Yan Guo, Ying Cui, Sheng Li, Ying Gao*. ROCK1 Induces ERK Nuclear Translocation in PDGF-BB Stimulated Migration of Rat Vascular Smooth Muscle Cells. IUBMB Life. 64(2):194-202, 2012. (7) Shuqing Liu, Fan Yang, Qiaoqiao Zhang, Ming-zhong Sun, Ying Gao*, Shujuan Shao*. “Anatomiacal” view of the protein composition and protein characteristics for Gloydius shedaoensis snake venom via proteomics approach. Anat Rec. 294(2), 273-282, 2011.

专利、著作版权等

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