教育背景
2000.05-2002.06 协和医科大学 肿瘤学 联合培养博士
大连医科大学
1990.09-1993.06 辽宁师范大学 生物学 硕士
1984.09-1988.08 辽宁师范大学 生物学 学士
工作经历
2015.01-至今 大连医科大学 研究生院院长
2006.06-2014.12 大连医科大学 学科发展规划处处长(博士生导师)
2004.06-2006.06 大连医科大学 硕士生导师 教授
1999.06-2004.06 大连医科大学 硕士生导师 副教授
1994.08-1999.06 大连医科大学 讲师
项目课题经历
1.长链非编码RNA-AS1在肺癌EMT中的作用及其机制(81773122), 国家自然科学基金,项目负责人,2018-2020,51万
2.肿瘤干细胞的动态演进与干预研究(2012CB967003), 科技部“973”课题,课题骨干,2012-2016,92.78万
3.针对恶性肿瘤细胞淋巴道转移预警的蛋白质组分离鉴定的新方法新技术研究(20935004), 国家自然科学基金重点项目,第二单位负责人,2010-2013,60万
3.能量代谢相关酶ALDOA在肺癌EMT中的作用及其机制研究(8ᠦ
论文、成果、著作等
1) ShujuanS,Rong L,Yang W,Yongmei S,Lihui Z,Liyan X,Ning L,Ning H,Mingrong W,Xiao Y,Qimin Z. Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice. J Clin Invest. 2010,120(2):498-507. 第一作者 IF= 14.152
2) Wu Donghua,Zhao Baofeng, Qi Xiaoyu,Peng Fang,Fu Hailu, Chi Xinming,Miao QingR,Shao Shujuan.Nogo-B receptor promotes epithelial-mesenchymal transition in non-small cell lung cancer cells through the Ras/ERK/Snail1 pathway.Cancer letters,2018,4(18):135-146. 通讯作者IF= 6.375
3) Li Huimin,Lin Zhikun, Bai Yuxin,Chi Xinming, Fu Hailu, Sun Rui, Liu Meizi,Liu Xuan,Chen Liying, Shao Shujuan.Sinomenine inhibits ovarian cancer cell growth and metastasis by mediating the Wnt/beta-catenin pathway via targeting MCM2. RSC ADVANCES , 2017, 7 ( 79 ): 50017 - 50026. 通讯作者IF= 3.108
4) Long Fei,Dong Chengyong,Jiang Keqiu, Xu Yakun, Chi Xinming, Sun Deguang, Liang Rui, Gao Zhenming, Shao Shujuan, Wang Liming,Melatonin enhances the anti-tumor effect of sorafenib via AKT/p27-mediated cell cycle arrest in hepatocarcinoma cell lines,RSC ADVANCES,2017, 7 ( 34): 21342 - 21351. 通讯作者IF= 3.108
5) Gao H, Sun B, Fu H, Chi X, Wang F, Qi X, Hu J, Shao S.PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway.Oncotarget.2016,7(33):53289-53298. 通讯作者IF= 5.168
6) Song Y, Sun B, Hao L, Hu J, Du S, Zhou X, Liu L, Gong L, Chi X, Liu Q, Shao S. Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma.Oncotarget.2016,7(36):58470-58482. 通讯作者IF= 5.168
7) Sun B, Bai Y, Zhang L, Gong L, Qi X, Li H, Wang F, Chi X, Jiang Y, Shao S. Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells..PLOS ONE ,2016, 11 (9):.e0163622. 通讯作者 IF= 2.806
8) Hao L,;Zhou X;Liu S;Sun M;Song Y;Du S;Sun B;Guo C;Gong L;Hu J;Guan H;Shao S.Elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas. Proteomics. 2015,15 (17):3087-3100. 通讯作者 IF=4.079
9) Sha Du., Zhuzhu Guan., Lihong Hao, Yang Song, Lan Wang, Linlin Gong, Lu Liu1, Xiaoyu Qi,Zhaoyuan Hou, Shujuan Shao. Fructose- Bisphosphate Aldolase A Is a Potential Metastasis-Associated Marker of Lung Squamous Cell Carcinoma and Promotes Lung Cell Tumorigenesis and Migration. PLOS ONE,2014,9:(1)e85804 通讯作者
10) Lihong H,Linlin G,Yiping G,Yang S, Xiaoyu Q, Zhuzhu G, Xiaohan Y, Xin Z,Liyan X,Shujuan S. Proteomics Approaches for Identification of Tumor Relevant Protein Targets in Pulmonary Squamous Cell Carcinoma by 2D-DIGE-MS.PLOS ONE ,2014, 9 (4):.e95121. 通讯作者
11) Benjamin A,Xin Z,Isaac O,Haoqi Z,Yang S,Xinming C,Bing S,Lihong H,Liyuan Z,Lu L,Hongwei G,Shujuan S.PRP19 upregulation inhibits cell proliferation in lung adenocarcinomas by p21-mediated induction of cell cycle arrest.BIOMEDICINE & PHARMACOTHERAPY,2014,68 (4):463-470. 通讯作者
12) Isaac O,Lan W, Linlin G,Benjamin A,Lihong H, Xin Z,Xiaoyu Q,Jun H,Shujuan S.Overexpression of JAKMIP1 associates with Wnt/beta-catenin pathway activation and promotes cancer cell proliferation in vitro. Biomed Pharmacother. 2013,67(3):228-34. 通讯作者
13) Zhou X, Xue L, Hao L, Liu S, Zhou F, Xiong H, Qi X, Lin D, Shao S. Proteomics-based identification of tumor relevant proteins in lung adenocarcinoma. Biomed Pharmacother.2013,67(7):621-7. 通讯作者(IF= 2.0)
14) Xiaohan Y,Hai X,Zhuzhu G,Isaac O,Dongmei Y,Yang S,Xiao L,Lan W,Lu L,Sha D,Dongmei L,Shujuan S.Higher expression of caveolin-1 inhibits human small cell lung cancer (SCLC) apoptosis in vitro. Cancer Invest.2012,30(6):453-62. 通讯作者
15) Wang N,Zhou F,Xiong H,Du S,Ma J,Okai I,Wang J,Suo J,Hao L,Song Y,Shao S.Screening and identification of distant metastasis-related differentially expressed genes in human squamous cell lung carcinoma. Anat Rec (Hoboken). 2012,295(5):748-57. 通讯作者
16) Sun MZ, Guan Z, Liu S, Zhou X, Wang N, Shao S, Lin D. Caveolin-1 interferes cell growth of lung cancer NCI-H446 cell through the interactions with phospho-ERK1/2, estrogen receptor and progestin receptor. Biomed Pharmacother. 2012,66(4):242-8. 通讯作者
17) Yang X, Xiong H, Guan ZZ, Okai I, Ye D, Song Y, Li X, Wang L, Liu L, Du S, Lin D, Shao S. Higher expression of Caveolin-1 inhibits human small cell lung cancer (SCLC) apoptosis in vitro. Cancer Invest.2012,30(6):453-62. 通讯作者
18) Song Y, Xue L, Du S, Sun M, Hu J, Hao L, Gong L, Yeh D, Xiong H, Shao S.Caveolin-1 knockdown is associated with the metastasis and proliferation of human lung cancer cell line NCI-H460. Biomed Pharmacother.2012, 66(6):439-447. 通讯作者
19) Wang Y, Chen D, Qian H, Tsai YS, Shao S, Liu Q, Dominguez D, Wang Z.The Splicing Factor RBM4 Controls Apoptosis, Proliferation, and Migration to Suppress Tumor Progression. Cancer Cell. 2014,26(3):374-89. IF= 23.893
20) Dong C, Zhao B, Long F, Liu Y, Liu Z, Li S, Yang X, Sun D, Wang H, Liu Q, Liang R, Li Y, Gao Z, Shao S, Miao QR, Wang L. Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein. Oncotarget. 2016,7(8):8850-8865.
21) Xiao Li, Jing Suo, Shujuan Shao, Liyan Xue, Wei Chen, Lijia Dong, Ji Shi, Ming Fu, Ning Lu,Qimin Zhan. Tong Tong. Overexpression of OLC1 Promotes Tumorigenesis of Human Esophageal Squamous Cell Carcinoma. PLOS ONE, 2014,9 (3):.e909588.
22) Yokoyama NN, Shao S, Hoang BH, Mercola D, Zi X. Wnt signaling in castration-resistant prostate cancer: implications for therapy. Am J Clin Exp Urol. 2014,15;2(1):27-44.
23) Li E, Xu Z, Liu F, Wang H, Wen J, Shao S, Zhang L, Wang L, Liu C, Lu J, Wang W, Gao Z, Wang Q . Continual exposure to cigarette smoke extracts induces tumor-like transformation of human nontumor bronchial epithelial cells in a microfluidic chip.J Thorac Oncol.2014,9(8):1091-100.
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