1996/8-1999/7 生物化学及分子生物学 医学博士 大连医科大学 1990/8-1993/7 免疫及微生物 医学硕士 大连医科大学 1980/8-1983/7 公共卫生 沈阳医学院

1993.07-今 大连医科大学微生态教研室 （讲师、副教授、教授）

1. 国家自然科学基金主任基金（81641029）：优势菌群调节肠粘膜屏障通透性影响糖尿病糖吸收的机制研究，2017.01-2017.12,10万元，主持人； 2. 973计划项目（2013CB531405）：肠道微生态与代谢、免疫调控的网络互作关系研究，2013.01-2017.12，50万元，主持人； 3.十二五支撑计划子课题，微生态肠内营养制剂及产品研发，150万 元，2013.1-2018.12，排名2； 4. 863计划子课题（2014AA022200）：药食同源生物资源挖掘关键技 术与产品ᠦ୔

1.Yanjie Guo, XuefeiYang, Yane Qi, Shu Wen, Yinhui Liu, Shaoying Tang,Rongsheng Huang， Li Tang*，Long-term use of ceftriaxone sodium induced changes in gut microbiota and immune system. Scientific reports. 2017 Feb. 21, 7:43035 2.Li M, Li Z, Wen S, Liu Y, Wang Y, and Tang L*. Transplantation of a bacterialconsortium ameliorates Trinitrobenzenesulfonic acid-induced colitis and intestinaldysbiosis in rats. Future Microbiology. 2016，11(7): 887–902.（SCI收录） 3. Guo Y, Qi Y, Yang X, Zhao L, Wen S, Liu Y, Tang L.Association between Polycystic Ovary Syndrome and Gut Microbiota. PLoS One. 2016, Apr 19;11(4):e0153196. （SCI收录） 4. Ming Li, Pin Liang, Zhenzhen Li, Ying Wang , Guobin Zhang, Hongwei Gao,Shu Wen and Li Tang, Fecal microbiota transplantation and bacterial consortium transplantation have comparable effects on the re-establishment of mucosal barrier function in mice with intestinal dysbiosis. Frontiers in Microbiology. 2015,07, 6:692. （SCI收录） 5. Li M, Li W, Wen S, Liu Y, Tang L*，Effects of ceftriaxone-induced intestinal dysbacteriosis on dendritic cells of small intestine in mice.Microbiol Immunol. 2013，57（8）：561-568. （SCI收录） 6.Fei Gao, Ming Li, Yinhui Liu, Chuanzhou Gao, Shu Wen, Li Tang*. Intestinal dysbacteriosis induces changes of T lymphocyte subpopulations in Peyer's patches of mice and orients the immune response towards humoral immunity. Gut Patho, 2012, 4:19.（SCI收录） 7. Lisha Tan, Shu Wen, Ming-Zhong Sun, Li Tang*.Changes in Protein Profile in Cecum of Mouse with Intestinal Dysbacteriosis Induced by Ceftriaxone Sodium. Journal of Hard Tissue Biology2011,20(2):93-98.（SCI收录） 8. Chun-Liang Liu, Shu Wen, Yin-Hui Liu, Hua-Jun Li, Jing Xiao and Li Tang*. Extracellular Nucleic Acids Secreted by Lactobacillus Regulate TLR9 Expression. Journal of Hard Tissue Biology2011,20 (2):163-170. （SCI收录） 9. Zongxin Ling, Shu Wen and Li Tang*. Inhibition of VSV by Extracellular RNA from Culture Filtrate of Lactobacillus DM8909 in Vitro. Journal of Hard Tissue Biology2011,20 (3) :241-250. （SCI收录）